Proteinuria disappears promptly after simultaneous kidney-pancreas transplantation in nephronic diabetic patients with near-normal GFR

Clinical Nephrology

Volumn 68, Issue 5, 2007, Pages 330-334

  Sedlak, M ^a   Biesenbach, George ^a   Margreiter, R ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Kidney pancreas transplantation; Nephronic syndrome; Proteinuria; Type 1 diabetes

Indexed keywords

CREATININE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS; TECHNETIUM 99M;

ADULT; ARTICLE; CASE REPORT; CONTINUOUS INFUSION; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DISEASE SEVERITY; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN PUMP; KIDNEY FUNCTION TEST; KIDNEY PANCREAS TRANSPLANTATION; KIDNEY SCINTISCANNING; NEPHROTIC SYNDROME; PROTEIN URINE LEVEL; PROTEINURIA; TREATMENT INDICATION; URINALYSIS; URINE SEDIMENT;

EID: 35748954936     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/cnp68330     Document Type: Article

References (15)

1. Becker BN, Rush SH, Dykstra DM et al. Preemptive transplantation for patients with diabetes-related kidney disease. Arch Intern Med. 2006; 166: 44-48.
2. Bohman SO, Tyden G, Wilczek H et al. Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes. 1985; 34: 306-308.
3. Borie DC, Larson MJ, Flores MG et al. Combined use of the JAK3 inhibitor CP-690, 550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates. Transplantation. 2005; 27: 1756-1764.
4. Cheung AH, Sutherland DE, Gillingham HJ, McHugh LE, Mondry-Munns KC, Dunn DL, Najarian JS, Matas AJ. Simultaneous pancreas-kidney tnsnsplant versus kidney transplant alone in diabetic patients. Kidney Int. 1992; 4: 924-928.
5. Copelli A, Giannarelli R, Vistoli F, Del Prato S et al. The beneficial effects of pancreas transplant alone in diabetic nephropathy. Diabetes. 2005; 28: 1366-1370.
6. Farney AC, Cho E, Schweitzer EJ et al. Simultaneous cadaver pancreas living donor kidney transplantation: a new approach for Type q diabetic uremic patients. Ann Surg 2000; 232: 696-703.
7. Knoll GA, Nichol G. Dialysis, kidney transplantation, or pancreas transplantation for patients with diabetes mellitus and renal failure: a decision analysis of treatment options. J Am Soc Nephrol. 2003; 4: 500-515.
8. Margreiter M, Steurer W, Spechtenhauser B, Königsrainer A. Kidney transplantation together with another solid organ from the same donor - a single-center progress report. Clin Nephrol. 2000; 53 Suppl: 38-43.
9. Mezza E, Grassi G, Dani F, Rossetti M et al. Preemptive pancreas-kidney transplantation: multidisciplinary follow-up starts too late. Transplant Proc. 2004; 36: 580-581.
10. Piccoli GB, Rossetti M, Marchetti P, Grassi G et al. Referral of Type 1 diabetic patients to a nephrology unit: will preemptive transplantation change our life? J Nephrol. 2004; 17: 275-283.
11. Piccoli GB, Rossetti M, Marchetti P, Grassi G et al. Complete reversal of the nephrotic syndrome after preemptive pancreas-kidney transplantation: a case report. Transplant Proc. 2004; 36: 589-590.
12. Piccoli GB, Mezza E, Piciotto G, Burdese M et al. The grafts kidneys take over: disappearance of the nephrotic syndrome after preemptive pancreas-kidney and kidney transplantation in diabetic nephropathy. Transplantation 2004; 78: 627-630.
13. Remmuzi G, Benigni A, Remmuzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 2006; 116: 288-296.
14. Steurer W, Malaise J, Mark W, Königsrainer A, Margreiter R, Euro-SPK Study Group. Spectrum of surgical complications after simultaneous pancreas-kidney transplantation in a prospectively randomized study of two immunosuppressive protocols. Nephrol Dial Transplant. 2004; 20 Suppl: 54-62.
15. Taylor jr A, Eshima D, Christian PE, Wooten WW, Hansen L, McElvany K. Technetium-99m MAG3 kit formulation: preliminary results in normal volunteers and patients with renal failure. J Nucl Med. 1988; 29: 616-622.