Methimazole-induced cholestatic jaundice in an elderly hyperthyroid patient

American Journal Geriatric Pharmacotherapy

Volumn 5, Issue 3, 2007, Pages 236-240

  Ramos Bonner, Luz S ^a,b   Goldberg, Todd H ^a   Moyer, Susan ^a   Anastasopoulou, Catherine ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b ST FRANCIS MEDICAL CENTER   (United States)

Author keywords

cholestatic jaundice; elderly; hepatitis; methimazole

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BILIRUBIN; CALCIUM; LIVER ENZYME; METOPROLOL; MULTIVITAMIN; PANTOPRAZOLE; RALOXIFENE; RAMIPRIL; THIAMAZOLE; THYROTROPIN; THYROXINE;

ABNORMAL LABORATORY RESULT; ACUTE HEPATITIS; AGED; ARTICLE; BILIRUBIN BLOOD LEVEL; CASE REPORT; CORONARY ARTERY DISEASE; DISEASE DURATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; ELDERLY CARE; FATIGUE; FEMALE; HAND TREMOR; HOSPITALIZATION; HUMAN; HYPERBILIRUBINEMIA; HYPERLIPIDEMIA; HYPERTHYROIDISM; KIDNEY CARCINOMA; LIVER FUNCTION TEST; NEPHRECTOMY; OBSTRUCTIVE JAUNDICE; OSTEOARTHRITIS; OSTEOPOROSIS; PEPTIC ULCER; PRIORITY JOURNAL; PRURITUS; SIDE EFFECT; SOMNOLENCE; TACHYCARDIA; THYROID NODULE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TOXIC HEPATITIS; TREATMENT DURATION; WEIGHT REDUCTION;

AGED; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANTITHYROID AGENTS; BILIRUBIN; FEMALE; HUMANS; HYPERTHYROIDISM; JAUNDICE, OBSTRUCTIVE; LIVER FUNCTION TESTS; METHIMAZOLE;

EID: 35748938450     PISSN: 15435946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjopharm.2007.10.003     Document Type: Article

References (25)

1. Tunbridge W., Evered D., Hall R., et al. The spectrum of thyroid disease in a community: The Wickham survey. Clin Endocrinol (Oxf) 7 (1977) 481-493
2. Furszyfer J., Kurland L., McConahey W., et al. Epidemiologic aspects of Hashimoto's thyroiditis and Graves' disease in Rochester, Minnesota (1935-1967), with special reference to temporal trends. Metabolism 21 (1972) 197-204
3. Cooper D. Thyroid disorders. In: Cassel C., Cohen H., Larson E., et al. (Eds). Geriatric Medicine (1997), Springer Verlag, New York, NY 491-510
4. Herrmann J., Heinen E., Kroll H., et al. Thyroid function and thyroid hormone metabolism in elderly people. Low T3-syndrome in old age?. Klin Wochenschr 59 (1981) 315-323
5. Gregerman R., Gaffney G., Shock N., and Crowder S. Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest 41 (1962) 2065-2074
6. Ingbar S. Effect of aging on thyroid economy in man. J Am Geriatr Soc 24 (1976) 49-53
7. Diez J. Hyperthyroidism in patients older than 55 years: An analysis of etiology and management. Gerontology 49 (2003) 316-323
8. Livingston E., Hershman J., Sawin C., and Yoshikawa T. Prevalence of thyroid disease and abnormal thyroid tests in older hospitalized and ambulatory persons. J Am Geriatr Soc 35 (1987) 109-114
9. Helfand M., and Crapo L. Screening for thyroid disease. Ann Intern Med 112 (1990) 840-849
10. Miller M. Disorders of the thyroid. In: Brocklehurst J., Tallis R., and Fillit H. (Eds). Brocklehurst's Textbook of Geriatric Medicine and Gerontology (1992), Churchill Livingstone, London, England 701-716
11. McDougal I. Treatment of hyper- and hypothyroidism. J Clin Pharmacol 21 (1981) 265-384
12. Rosenbaum H. Agranulocytosis and toxic hepatitis from methimazole. J Am Med Assoc 152 (1953) 27
13. Miller M. Disorders of the thyroid. In: Brocklehurst J., Tallis R., and Fillit H. (Eds). Brocklehurst's Textbook of Geriatric Medicine and Gerontology (1998), Churchill Livingstone, London, England 1023-1041
14. Physicians' Desk Reference. Methimazole. 58th (2005), Thomson PDR, Montvale, NJ. http://www.fda.gov/cder/foi/label/2001/07517s221bl.pdf Available at: Accessed September 20, 2007
15. Orgiazzi J. Management of Graves' hyperthyroidism. Endocrinol Metab Clin North Am 16 (1987) 365-389
16. Mikhail N. Methimazole-induced cholestatic jaundice. South Med J 97 (2005) 178-182
17. Wing S., and Fantus I. Adverse immunologic effects of antithyroid drugs. CMAJ 136 (1987) 121-127
18. Kang H., Choi J., Jung I., et al. A case of methimazole-induced hepatic failure in a patient with chronic hepatitis B carrier. Korean J Intern Med 5 (1990) 69-73
19. Findor J., Bruch Igartua E., Sorda J., and Jury R. Jaundice caused by methimazole [in Spanish]. Acta Gastroenterol Latinoam 21 (1991) 115-119
20. Hung Y., Yu W., and Chow E. Delayed cholestatic hepatitis due to methimazole. Hong Kong Med J 5 (1999) 200-201
21. Fischer M., Nayer H., and Miller A. Methimazole-induced jaundice. JAMA 223 (1973) 1028-1029
22. Schwab G., Wetscher G., Vogl W., and Redmond E. Methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis. Langenbecks Arch Chir 381 (1996) 225-227
23. Tennenbaum J., and Dreskin O. Toxic hepatitis during treatment with methimazole (Tapazole). Report of a case with apparent recovery. Ohio Med 58 (1962) 306-307
24. Arab D., Malatjalian D., and Rittmaster R. Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole. J Clin Endocrinol Metab 80 (1995) 1083-1085
25. Naranjo C., Busto U., Sellers E., et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (1981) 239-245