Feasibility of an in situ measurement device for bubble size and distribution

Bioprocess and Biosystems Engineering

Volumn 30, Issue 5, 2007, Pages 313-326

  Junker, Beth ^a   Maciejak, Walter ^a   Darnell, Branson ^b   Lester, Michael ^a   Pollack, Michael ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Enviroptics   (United States)

Author keywords

Bubbles; Distribution; Fermenter; Image analysis; In situ; Measurement; Size

Indexed keywords

FERMENTERS; IMAGE ANALYSIS; LIGHT EMITTING DIODES; MEASUREMENTS; PROBES; REAL TIME SYSTEMS; STAINLESS STEEL; STATISTICAL METHODS;

AERATION RATES; AGITATION RATES; ANIMAL CELL BROTHS; COTTONSEED FLOUR; DISTRIBUTION; MODULAR CAMERA SYSTEMS; PROBE MEASUREMENT SYSTEMS;

BUBBLE FORMATION;

STAINLESS STEEL; WATER;

ARTICLE; BIOREACTOR; BUBBLE SIZE; CAMERA; COMPUTER PROGRAM; DEVICE; IMAGE ANALYSIS; IN SITU MEASUREMENT DEVICE; LIGHT; LIGHT EMITTING DIODE; MECHANICAL PROBE; PARTICLE SIZE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; BIOTECHNOLOGY; CALIBRATION; CHEMISTRY; COMPUTER; CULTURE MEDIUM; EQUIPMENT DESIGN; FERMENTATION; INSTRUMENTATION; METHODOLOGY; MICROSCOPY; NORMAL DISTRIBUTION; TEMPERATURE; TIME; VIDEORECORDING;

MICROPUS;

BIOREACTORS; BIOTECHNOLOGY; CALIBRATION; COMPUTERS; CULTURE MEDIA; EQUIPMENT DESIGN; FERMENTATION; MICROSCOPY; NORMAL DISTRIBUTION; PARTICLE SIZE; SOFTWARE; TEMPERATURE; TIME FACTORS; VIDEO RECORDING; WATER;

EID: 35748932401     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-007-0127-y     Document Type: Article

References (24)

1. Akita K, Yoshida F (1974) Bubble size, interfacial area, and liquid phase mass transfer coefficient in bubble columns. Ind Eng Chem Process Des Develop 13(1):84-91
2. Junker B (2006) Measurement of bubble and pellet size distributions: past and current image analysis technology. Bioprocess Biosyst Eng 29:185-206
3. Pacek AW, Moore IPT, Nienow AW, Calabrese RV (1994) Video technique for measuring dynamics of liquid-liquid dispersion during phase inversion. AIChE J 40(12):1940-1949
4. Pacek AW, Man CC, Nienow AW (1998) On the Sauter mean diameter and size distributions in turbulent liquid/liquid dispersions in a stirred vessel. Chem Eng Sci 52(11):2005-2011
5. Machon V, Pacek AW, Nienow AW (1997) Bubble sizes in electrolyte and alcohol solutions in a turbulent stirred vessel. Trans IChemE 75(Pt. A):339-348
6. Honkanen M, Saarenrinne P (2002) Turbulent bubbly flow measurements in a mixing vessel with PIV. In: Proceedings of the 11th international symposium on applications of laser techniques to fluid mechanics. Instituto Superior Technico, Lisbon, pp 1-12
7. O'Cleirigh C, Walsh PK, O'Shea DG (2003) Morphological quantification of pellets in Streptomyces hygroscopicus var. geldanus fermentation broths using a flatbed scanner. Biotechnol Lett 25:1677-1683
8. Malysa K, Ng S, Cymbalisty L, Czarnecki J, Masliyah J (1999) A method of visualization and characterization of aggregate flow inside a separation vessel, Part 1. Size, shape and rise velocity of the aggregates. Int J Miner Process 55:171-188
9. Coelho MAZ, Belo I, Pinheiro R, Amaral AL, Mota M, Coutinho JAP, Ferreira EC (2004) Effect of hyperbaric stress on yeast morphology: study by automated image analysis. Appl Microbiol Biotechnol 66:318-324
10. Nadimpalli UD, Price RR, Hall SG, Bomma P (2006) A comparison of image processing techniques for bird recognition. Biotechnol Prog 22:9-13
11. Pichon D, Vivier H, Pons MN (1992) Growth monitoring of mammalian cells on microcarriers by image analysis. In: Karim MN, Stephanopoulos G (eds) Modeling and control of biotechnical processes. Pergamon, Oxford, pp 311-314
12. Pan X-H, Luo R, Yang X-Y, Yang H-J (2002) Three dimensional particle image tracking for dilute particle-liquid flows in a pipe. Meas Sci Technol 13(8):1206-1216
13. Dudley BT, Howgrave-Graham AR, Bruton AG, Wallis FM (1993) Image analysis to quantify and measure UASB digester granules. Biotechnol Bioeng 42:279-283
14. Greaves M, Barigou M (1988) The internal structure of gas-liquid dispersions in a stirred reactor. In: Proceedings 6th European conference on mixing, BHRA, Fluid Engineering Centre, Bedford, pp 313-320
15. Barigou M, Greaves M (1992a) Bubble size distributions in a mechanically agitated gas-liquid contactor. Chem Eng Sci 47(8):2009-2025
16. Franz K, Buchholz R, Schugerl K (1980) Comprehensive study of the gas hold up and bubble size distributions in highly viscous liquids. Chem Eng Commun 5:165-202
17. Moo-Young M, Blanch HW (1981) Design of biochemical reactors, mass transfer criteria for simple and complex systems. Adv Biochem Eng 19:1-69
18. Walter JF, Blanch HW (1986) Bubble break-up in gas-liquid bioreactors: break-up in turbulent flows. Chem Eng J 32:B7-B17
19. Vermeulen T, Williams GM, Langlois GE (1955) Interfacial area in liquid-liquid and gas-liquid agitation. Chem Eng Prog 51(2):85F-94F
20. Kumar R, Kuloor NR (1970) The formation of bubbles and drops. In: Drew TB, Cokelet GR, Hoopes JW Jr, Vermeulen T (eds) Advances in chemical engineering, vol. 8. Academic, New York, pp 255-368
21. Rodger WA, Trice VG, Rushton JH (1956) Effect of fluid motion on interfacial area of dispersions. Chem Eng Prog 52(12):515-520
22. Laakkonen M, Honkanen M, Saarenrinne P, Aittamaa J (2005) Local bubble size distributions, gas-liquid interfacial areas and gas hold-ups in a stirred vessel with particle image velocimetry. Chem Eng J 109:37-47
23. Junker B (2004) Scale-up methodologies for Escherichia coli and yeast fermentation processes. J Biosci Bioeng 97(6):347-364
24. Junker BH, Stanik M, Barna C, Salmon P, Paul E, Buckland BC (1998) Influence of impeller type on power input in fermentation vessels. Bioprocess Eng 18:401-412