Improvement of dissolution properties of a new Helicobacter pylori eradicating agent (TG44) by inclusion complexation with β-cyclodextrin

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 10, 2007, Pages 1466-1470

  Anzai, Kinsei ^a   Mizoguchi, Jun Ichi ^a   Yanagi, Toshiharu ^a   Hirayama, Fumitoshi ^b   Arima, Hidetoshi ^c   Uekama, Kaneto ^b  

^a Nagase Chemtex Ltd   (Japan)

^b SOJO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

cyclodextrin; Dissolution; Helicobacter pylori eradicating agent; Inclusion complex; Solubility; TG44

Indexed keywords

4 METHYLBENZYL 4' [4 (GUANIDINOMETHYL)CYCLOHEXYLCARBONYLOXY]BIPHENYL 4 CARBOXYLATE MONOHYDROCHLORIDE; ANTIINFECTIVE AGENT; BETA CYCLODEXTRIN; TG 44; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG SOLUBILITY; ERADICATION THERAPY; FLUORESCENCE; HELICOBACTER PYLORI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTROSCOPY; X RAY DIFFRACTION;

BENZOATES; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; GUANIDINES; HELICOBACTER PYLORI; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SOLUBILITY; TEMPERATURE; TIME FACTORS; WATER; X-RAY DIFFRACTION;

EID: 35649027329     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1466     Document Type: Article

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