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Volumn , Issue 17, 2007, Pages 2635-2638

Total synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy

Author keywords

Alkaloids; Antitumor; Cyclizations; Natural products; Palladium

Indexed keywords

CAMPTOTHECIN; PALLADIUM;

EID: 35649017697     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-991054     Document Type: Article
Times cited : (22)

References (33)
  • 11
    • 0141927373 scopus 로고    scopus 로고
    • (e) Du, W. Tetrahedron 2003, 59, 8649.
    • (2003) Tetrahedron , vol.59 , pp. 8649
    • Du, W.1
  • 25
    • 35648966616 scopus 로고    scopus 로고
    • Synthesis of Compound 23: Procedure for the Pd-Catalyzed Cyclization Reaction To a stirred solution of compound 22 (0.2 g, 0.61 mmol) in DMF (3.0 mL) and H2O (1.0 mL) was added PdCl2 (0.007 g, 0.061 mmol) and CuCl2·2H2O (0.22 g, 1.2 mmol, The resultant dark green solution was heated at 95°C for 8 h. After the disappearance of starting material (TLC, the reaction mixture was cooled to r.t. Then, H2O (10 mL) was added and extracted with Et2O (3 x 15 mL, The combined organic layers were washed with H2O (3 x 10 mL, brine (10 mL, dried over anhyd Na2SO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography (SiO2) using EtOAc-PE (6:4) as an eluent to furnish cyclized product 23 as a pale yellow solid in 54% yield, mp 97-100°C. Spectroscopic Data for Compound 23 IR CHCl3, νmax
    • 3: C, 71.24; H, 5.03; N, 8.74. Found: C, 71.19; H, 5.11; N, 8.69.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.