The transcription of the gene for iso-orotate decarboxylase (IDCase), an enzyme of the thymidine salvage pathway, is downregulated in the preg c mutant strain of Neurospora crassa grown under phosphate starvation

Canadian Journal of Microbiology

Volumn 53, Issue 8, 2007, Pages 1011-1015

  Leal, Juliana ^a   Squina, Fabio M ^a   Martinez Rossi, Nilce M ^a   Rossi, Antonio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Coenzyme Q; Energy metabolism; Neurospora crassa; Nucleotide metabolism; Phosphorus regulation; Thymidine salvage pathway; Ubiquinone C methyltransferase

Indexed keywords

COENZYMES; GENES; MOLECULAR BIOLOGY; MUTAGENESIS; NUCLEOTIDES;

COENZYME Q; ENERGY METABOLISM; NEUROSPORA CRASSA; NUCLEOTIDE METABOLISM; PHOSPHORUS REGULATION; THYMIDINE SALVAGE PATHWAYS; UBIQUINONE C-METHYLTRANSFERASE;

TRANSCRIPTION;

CARBOXYLYASE; METHYLTRANSFERASE; OROTIC ACID; PHOSPHATE; THYMIDINE; UBIQUINONE;

ALLELE; DECARBOXYLATION; ENZYME ACTIVITY; GENE; METABOLISM; MOLECULAR ANALYSIS; MUTATION; PHOSPHATE; STARVATION;

ALLELE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS ISOLATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; NEUROSPORA CRASSA; NONHUMAN; NORTHERN BLOTTING; PH MEASUREMENT; PREG C GENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALVAGE THERAPY; STARVATION;

BLOTTING, NORTHERN; CARBOXY-LYASES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; HYDROGEN-ION CONCENTRATION; MUTATION; NEUROSPORA CRASSA; PHOSPHATES; THYMIDINE; TRANSCRIPTION, GENETIC;

NEUROSPORA CRASSA;

EID: 35649016087     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/W07-064     Document Type: Article

References (28)

1. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402. doi:10.1093/nar/25.17.3389.
2. Bussink, H.-J., and Osmani, S.A. 1998. A cyclin-dependent kinase family member (PHOA) is required to link developmental fate to environmental conditions in Aspergillus nidulans. EMBO J. 17: 3990-4003. doi:10.1093/emboj/17.14.3990.
3. Crocken, B., and Nyc, J.F. 1963. Utilization of L-α- glycerophosphorylcholine by a lecithin-deficient strain of Neurospora crassa. Can. J. Microbiol. 9: 689-696.
4. Galagan, J.E., Calvo, S.E., Borkovich, K.A., Selker, E.U., Read, N.D., Jaffe, D., et al. 2003. The genome sequence of the filamentous fungus Neurospora crassa. Nature, 422: 859-868. doi:10.1038/nature01554.
5. Gras, D.E., Silveira, H.C.S., Martinez-Rossi, N.M., and Rossi, A. 2007. Identification of genes displaying differential expression in the nuc-2 mutant strain of the mold Neurospora crassa grown under phosphate starvation. FEMS Microbiol. Lett. 269: 196-200. doi:10.1111/j.1574-6968. 2006.00613.x.
6. Han, S.W., Nahas, E., and Rossi, A. 1987. Regulation of synthesis and secretion of acid and alkaline phosphatases in Neurospora crassa. Curr. Genet. 11: 521-527. doi:10.1007/BF00384615.
7. Justino, A., Nozawa, S.R., Maccheroni, W., Jr., May, G.S., Martinez-Rossi, N.M., and Rossi, A. 2001. The Aspergillus nidulans pyrG89 mutation alters glycosylation of secreted acid phosphatase. Fungal Genet. Biol. 32: 113-120. doi:10.1006/fgbi.2001.1255.
8. Kaneshiro, E.S., Basselin, M., Merali, S., and Kayser, O. 2006. Ubiquinone synthesis and its regulation in Pneumocystis carinii. J. Eukaryot. Microbiol. 53: 435-444. doi:10.1111/j.1550-7408. 2006.00127.x.
9. + gene controlling the activity of the transcriptional activator NUC-1. Genetics, 133: 193-202.
10. Kawamukai, M. 2002. Biosynthesis, bioproduction and novel roles of ubiquinone. J. Biosci. Bioeng. 94: 511-517.
11. Lenburg, M.E., and O'Shea, E.K. 1996. Signaling phosphate starvation. Trends Biochem. Sci. 21: 383-387. doi:10.1016/0968-0004(96)10048-7.
12. Liang, P., and Pardee, A.B. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science (Washington, D.C.), 257: 967-971. doi:10.1126/science.1354393.
13. Littlewood, B.S., Chia, W., and Metzenberg, R.L. 1974. Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations. Genetics, 79: 419-434.
14. McDonald, A.E., Niere, J.O., and Plaxton, W.C. 2001. Phosphite disrupts the acclimation of Saccharomyces cerevisiae to phosphate starvation. Can. J. Microbiol. 47: 969-978. doi:10.1139/cjm-47-11-969.
15. Metzenberg, R.L. 1979. Implications of some genetic control mechanisms in Neurospora. Microbiol. Rev. 43: 361-383.
16. Nahas, E., Terenzi, H.F., and Rossi, A. 1982. Effect of carbon source and pH on the production and secretion of acid phosphatase (EC 3.1.3.2) and alkaline phosphatase (EC 3.1.3.1) in Neurospora crassa. J. Gen. Microbiol. 128: 2017-2021.
17. Paytan, A., and McLaughlin, K. 2007. The oceanic phosphorus cycle. Chem. Rev. 107: 563-576. doi:10.1021/cr0503613.
18. Peleg, Y., Addison, R., Aramayo, R., and Metzenberg, R.L. 1996a. Translocation of Neurospora crassa transcription factor NUC-1 into the nucleus is induced by phosphorus limitation. Fungal Genet. Biol. 20: 185-191. doi:10.1006/fgbi.1996.0034.
19. Peleg, Y., Aramayo, R., Kang, S., Hall, J.G., and Metzenberg, R. 1996b. NUC-2, a component of phosphate-regulated signal transduction pathway in Neurospora crassa, is an ankyrin repeat protein. Mol. Gen. Genet. 252: 709-716.
20. Schweingruber, M.E., Edenharter, E., Zurlinden, A., and Stockmaier, K.M. 1992. Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate. Curr. Genet. 22: 289-292. doi:10.1007/BF00317923.
21. Smiley, J.A., Kundracik, M., Landfried, D.A., Barnes, V.R., Sr., and Axhemi, A.A. 2005. Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa. Biochim. Biophys. Acta, 1723: 256-264.
22. Soballe, B., and Poole, R.K. 1999. Microbial ubiquinones: multiple roles in respiration, gene regulation and oxidative stress management. Microbiology (Reading, U.K.), 145: 1817-1830.
23. c strain of the mold Neurospora crassa? Plant Cell Physiol. 35: 837-840.
24. Turunen, M., Olsson, J., and Dallner, G. 2004. Metabolism and function of coenzyme Q. Biochim. Biophys. Acta, 1600: 171-199.
25. van Dooren, G.G., Stimmler, L.M., and McFadden, G.I. 2006. Metabolic maps and functions of the Plasmodium mitochondrion. FEMS Microbiol. Rev. 30: 596-630. doi:10.1111/j.1574-6976. 2006.00027.x.
26. Vogel, H.J. 1956. A convenient growth medium for Neurospora (Medium N). Microbial Genet. Bull. 13: 42-43. Available at www.fgsc.net/methods/vogels.html.
27. Waters, N.C., Knight, J.P., Creasy, C.L., and Bergman, L.W. 2004. The yeast Pho80-Pho85 cyclin-CDK complex has multiple substrates. Curr. Genet. 46: 1-9.
28. Wu, D., Dou, X., Hashmi, S.B., and Osmani, S.A. 2004. The Pho80-like cyclin of Aspergillus nidulans regulates development independently of its role in phosphate acquisition. J. Biol. Chem. 279: 37693-37703. doi:10.1074/jbc.M403853200.