Extracellular matrix and airway smooth muscle interactions: A target for modulating airway wall remodelling and hyperresponsiveness?

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 7, 2007, Pages 666-671

  Tran, Thai ^a   Halayko, Andrew J ^a  

^a NONE

Author keywords

Airway function; Airway hyperresponsiveness; Airway smooth muscle; Airway wall remodelling; Asthma; Extracellular matrix; Integrins; Phenotype plasticity

Indexed keywords

GELATINASE A; GELATINASE B; INTEGRIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

AIRWAY; ASTHMA; BREATHING MUSCLE; CONFERENCE PAPER; EXTRACELLULAR MATRIX; HUMAN; MUSCLE FUNCTION; MUSCLE MASS; PHENOTYPE; PLASTICITY; PRIORITY JOURNAL; SMOOTH MUSCLE;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY SYSTEM;

EID: 35649008451     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y07-050     Document Type: Conference Paper

References (56)

1. Altraja, A., Laitinen, A., Virtanen, I., Kampe, M., Simonsson, B.G., Karlsson, S.E., et al. 1996. Expression of laminins in the airways in various types of asthmatic patients: a morphometric study. Am. J. Respir. Cell Mol. Biol. 15: 482-488.
2. Amin, K., Ludviksdottir, D., Janson, C., Nettelbladt, O., Bjornsson, E., Roomans, G.M., et al. 2000. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. Am. J. Respir. Crit. Care Med. 162: 2295-2301.
3. Badalamente, M.A., Hurst, L.C., and Hentz, V.R. 2002. Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J. Hand Surg. [Am.], 27: 788-798. doi:10.1053/jhsu.2002.35299.
4. Barnes, P.J. 1998. Pharmacology of airway smooth muscle. Am. J. Respir. Crit. Care Med. 158: S123-S132.
5. Beasley, R., Roche, W.R., Roberts, J.A., and Holgate, S.T. 1989. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 139: 806-817.
6. Bel, E.H. 2006. "Hot stuff": bronchial thermoplasty for asthma. Am. J. Respir. Crit. Care Med. 173: 941-942. doi:10.1164/rccm.2602002.
7. Benayoun, L., Druilhe, A., Dombret, M.C., Aubier, M., and Pretolani, M. 2003. Airway structural alterations selectively associated with severe asthma. Am. J. Respir. Crit. Care Med. 167: 1360-1368. doi:10.1164/rccm.200209- 1030OC.
8. Bousquet, J., Chanez, P., Lacoste, J.Y., Enander, I., Venge, P., Peterson, C., et al. 1991. Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma. J. Allergy Clin. Immunol. 88: 649-660. doi:10.1016/0091-6749(91)90159-L.
9. Bramley, A.M., Thomson, R.J., Roberts, C.R., and Schellenberg, R.R. 1994. Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance. Eur. Respir. J. 7: 337-341. doi:10.1183/09031936.94.07020337.
10. Bramley, A.M., Roberts, C.R., and Schellenberg, R.R. 1995. Collagenase increases shortening of human bronchial smooth muscle in vitro. Am. J. Respir. Crit. Care Med. 152: 1513-1517.
11. Brewster, C.E., Howarth, P.H., Djukanovic, R., Wilson, J., Holgate, S.T., and Roche, W.R. 1990. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 3: 507-511.
12. Burgess, J.K., Ge, Q., Poniris, M.H., Boustany, S., Twigg, S.M., Black, J.L., and Johnson, P.R. 2006. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L153-L161.
13. Chan, V., Burgess, J.K., Ratoff, J.C., O'Connor, B.J., Greenough, A., Lee, T.H., and Hirst, S.J. 2006. Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells. Am. J. Respir. Crit. Care Med. 174: 379-385. doi:10.1164/rccm.200509-1420OC.
14. Cortijo, J., Sanz, M.J., Iranzo, A., Montesinos, J.L., Nabah, Y.N., Alfon, J., et al. 2006. A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. Br. J. Pharmacol. 147: 661-670. doi:10.1038/sj.bjp.0706658.
15. Cox, G., Miller, J.D., McWilliams, A., Fitzgerald, J.M., and Lam, S. 2006. Bronchial thermoplasty for asthma. Am. J. Respir. Crit. Care Med. 173: 965-969. doi:10.1164/rccm.200507-1162OC.
16. Davidson, J.M. 1990. Biochemistry and turnover of lung interstitium. Eur. Respir. J. 3: 1048-1063.
17. Dunnill, M.S., Massarella, G.R., and Anderson, J.A. 1969. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax, 24: 176-179.
18. Ebina, M., Takahashi, T., Chiba, T., and Motomiya, M. 1993. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am. Rev. Respir. Dis. 148: 720-726.
19. Fernandes, D.J., Bonacci, J.V., and Stewart, A.G. 2006. Extracellular matrix, integrins, and mesenchymal cell function in the airways. Curr. Drug Targets, 7: 567-577. doi:10.2174/138945006776818700.
20. Hirst, S.J., Twort, C.H., and Lee, T.H. 2000. Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am. J. Respir. Cell Mol. Biol. 23: 335-344.
21. Hoshino, M., Nakamura, Y., and Sim, J.J. 1998. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax, 53: 21-27.
22. Iyer, S.N., Wild, J.S., Schiedt, M.J., Hyde, D.M., Margolin, S.B., and Giri, S.N. 1995. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. J. Lab. Clin. Med. 125: 779-785.
23. Iyer, S.N., Gurujeyalakshmi, G., and Giri, S.N. 1999. Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J. Pharmacol. Exp. Ther. 291: 367-373.
24. Jeffery, P.K., Wardlaw, A.J., Nelson, F.C., Collins, J.V., and Kay, A.B. 1989. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am. Rev. Respir. Dis. 140: 1745-1753.
25. Johnson, P.R. 2001. Role of human airway smooth muscle in altered extracellular matrix production in asthma. Clin. Exp. Pharmacol. Physiol. 28: 233-236. doi:10.1046/j.1440-1681.2001.03426.x.
26. Johnson, S., and Knox, A. 1999. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am. J. Physiol. 277: L1109-L1117.
27. Johnson, P.R., Black, J.L., Carlin, S., Ge, Q., and Underwood, P.A. 2000. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am. J. Respir. Crit. Care Med. 162: 2145-2151.
28. Johnson, P.R., Roth, M., Tamm, M., Hughes, M., Ge, Q., King, G., Burgess, J.K., and Black, J.L. 2001. Airway smooth muscle cell proliferation is increased in asthma. Am. J. Respir. Crit. Care Med. 164: 474-477.
29. Johnson, P.R., Burgess, J.K., Underwood, P.A., Au, W., Poniris, M.H., Tamm, M., et al. 2004. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J. Allergy Clin. Immunol. 113: 690-696. doi:10.1016/j.jaci.2003.12.312.
30. Johnson, P.R., Burgess, J.K., Ge, Q., Poniris, M., Boustany, S., Twigg, S.M., and Black, J.L. 2006. Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. Am. J. Respir. Crit. Care Med. 173: 32-41. doi:10.1164/rccm.200406-703OC.
31. Kranenburg, A.R., Willems-Widyastuti, A., Moori, W.J., Sterk, P.J., Alagappan, V.K., de Boer, W.I., and Sharma, H.S. 2006. Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease. Am. J. Clin. Pathol. 126: 725-735.
32. Laitinen, A., Altraja, A., Kampe, M., Linden, M., Virtanen, I., and Laitinen, L.A. 1997. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am. J. Respir. Crit. Care Med. 156: 951-958.
33. Lambert, R.K., Wiggs, B.R., Kuwano, K., Hogg, J.C., and Pare, P.D. 1993. Functional significance of increased airway smooth muscle in asthma and COPD. J. Appl. Physiol. 74: 2771-2781.
34. Lasky, J. 2004. Pirfenidone. IDrugs, 7: 166-172.
35. Lemjabbar, H., Gosset, P., Lamblin, C., Tillie, I., Hartmann, D., Wallaert, B., Tonnel, A.B., and Lafuma, C. 1999. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am. J. Respir. Crit. Care Med. 159: 1298-1307.
36. Lobb, R.R., and Adams, S.P. 1999. Small molecule antagonists of alpha4 integrins: novel drugs for asthma. Expert Opin. Investig. Drugs, 8: 935-945. doi:10.1517/13543784.8.7.935.
37. McDonald, J.A., Broekelmann, T.J., Matheke, M.L., Crouch, E., Koo, M., and Kuhn, C., 3rd. 1986. A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. Detection of an altered fibroblast phenotype in lungs of patients with pulmonary fibrosis. J. Clin. Invest. 78: 1237-1244.
38. Mookerjee, I., Solly, N.R., Royce, S.G., Tregear, G.W., Samuel, C.S., and Tang, M.L. 2006. Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease. Endocrinology, 147: 754-761.
39. Nguyen, T.T., Ward, J.P., and Hirst, S.J. 2005. beta1-Integrins mediate enhancement of airway smooth muscle proliferation by collagen and fibronectin. Am. J. Respir. Crit. Care Med. 171: 217-223.
40. Niimi, A., Matsumoto, H., Takemura, M., Ueda, T., Chin, K., and Mishima, M. 2003. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am. J. Respir. Crit. Care Med. 168: 983-988. doi:10.1164/rccm.200211-1268OC.
41. Oltmanns, U., Sukkar, M.B., Xie, S., John, M., and Chung, K.F. 2005. Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. Am. J. Respir. Cell Mol. Biol. 32: 334-341. doi:10.1165/rcmb.2004-0321OC.
42. Opazo Saez, A.M., Schellenberg, R.R., Ludwig, M.S., Meiss, R.A., and Pare, P.D. 2002. Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species. Can. J. Physiol. Pharmacol. 80: 865-871. doi:10.1139/y02-112.
43. Pare, P.D., Roberts, C.R., Bai, T.R., and Wiggs, B.J. 1997. The functional consequences of airway remodeling in asthma. Monaldi Arch. Chest Dis. 52: 589-596.
44. Peng, Q., Lai, D., Nguyen, T.T., Chan, V., Matsuda, T., and Hirst, S.J. 2005. Multiple beta 1 integrins mediate enhancement of human airway smooth muscle cytokine secretion by fibronectin and type I collagen. J. Immunol. 174: 2258-2264.
45. Phipps, S., Benyahia, F., Ou, T.T., Barkans, J., Robinson, D.S., and Kay, A.B. 2004. Acute allergen-induced airway remodeling in atopic asthma. Am. J. Respir. Cell Mol. Biol. 31: 626-632. doi:10.1165/rcmb.2004-0193OC.
46. Pini, L., Hamid, Q., Shannon, J., Lemelin, L., Olivenstein, R., Ernst, P., et al. 2007. Differences in proteoglycan deposition in the airway of moderate and severe asthmatics. Eur. Respir. J. 29: 71-77.
47. Roberts, C.R. 1995. Is asthma a fibrotic disease? Chest, 107: 111S-117S.
48. Roberts, C.R., and Burke, A.K. 1998. Remodelling of the extracellular matrix in asthma: proteoglycan synthesis and degradation. Can. Respir. J. 5: 48-50.
49. Roche, W.R., Beasley, R., Williams, J.H., and Holgate, S.T. 1989. Subepithelial fibrosis in the bronchi of asthmatics. Lancet, 1: 520-524.
50. Sobonya, R.E. 1984. Quantitative structural alterations in long-standing allergic asthma. Am. Rev. Respir. Dis. 130: 289-292.
51. Soroff, H.S., and Sasvary, D.H. 1994. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. J. Burn Care Rehabil. 15: 13-17. doi:10.1097/00004630-199401000-00003.
52. Tran, T., McNeill, K.D., Gerthoffer, W.T., Unruh, H., and Halayko, A.J. 2006. Endogenous laminin is required for human airway smooth muscle cell maturation. Respir. Res. 7: 117. doi:10.1186/1465-9921-7-117.
53. Tran, T., Ens-Blackie, K., Rector, E.S., Stelmack, G.L., McNeill, K.D., Tarone, G. 2007. Laminin-binding integrin α7 is required for contractile phenotype expression by human airway myocytes. Am. J. Respir. Cell Mol. Biol. July 19 [EPub ahead of print]. doi:10.1165/rcmb.2007-0165OC.
54. Wilson, J.W., Li, X., and Pain, M.C. 1993. The lack of distensibility of asthmatic airways. Am. Rev. Respir. Dis. 148: 806-809.
55. Woodruff, P.G., Dolganov, G.M., Ferrando, R.E., Donnelly, S., Hays, S.R., Solberg, O.D., et al. 2004. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am. J. Respir. Crit. Care Med. 169: 1001-1006. doi:10.1164/rccm.200311-1529OC.
56. Zhang, S., Howarth, P.H., and Roche, W.R. 1996. Cytokine production by cell cultures from bronchial subepithelial myofibroblasts. J. Pathol. 180: 95-101. doi:10.1002/(SICI)1096-9896(199609)180:1〈95::AID- PATH614〉3.0.CO;2-B.