Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice

Drug Development and Industrial Pharmacy

Volumn 33, Issue 10, 2007, Pages 1058-1069

  Thornton, Sheila J ^a   Warburton, Corinna ^a   Wasan, Kishor M ^a   Kozlowski, Piotr ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Adipose accumulation; FM VP4; Mice; Obesity; Phytosterol analog

Indexed keywords

ANTILIPEMIC AGENT; DISODIUM ASCORBYL PHYTOSATNOL PHOSPHATE; FECES LIPID; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FATTY ACID BLOOD LEVEL; FECES ANALYSIS; FEMUR; FLUID INTAKE; FOOD INTAKE; GROWTH; LEAN BODY WEIGHT; LIPID ABSORPTION; LIPID DIET; LIPID STORAGE; LIVER; LOW FAT DIET; MALE; METABOLIC RATE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; STATISTICAL SIGNIFICANCE;

ADIPOSE TISSUE; ANIMALS; ANTICHOLESTEREMIC AGENTS; BODY COMPOSITION; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; LIPIDS; MALE; MICE; MICE, INBRED C57BL; OBESITY; OXYGEN CONSUMPTION; PHYTOSTEROLS;

EID: 35649006931     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040601133746     Document Type: Article

References (14)

1. Das UN. (2001). Is obesity an inflammatory condition? Nutrition, 17, 953-966.
2. Folch, J., Lees, M., & Sloane Stanley, G. H. (1957). A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226(1), 497-509.
3. Garcia-Sancho Tellez, L., Gomez de Segura, I. A., Vazquez, I., De Miguel, E., & Garcia-Sancho, L. (2001). Growth hormone effects in intestinal adaptation after massive bowel resection in the suckling rat. JPGN, 33, 477-482.
4. Hambly, C., Adams, A., Fustin, J.-M., Rance, K. A., Bunger, L., & Speakman, J. R. (2005). Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. Obes. Res., 13, 556-566.
5. Johnson, M. S., Thomson, S. C., & Speakman, J. R. (2001). Limits to sustained energy intake: II. Inter-relationships between resting metabolic rate, life-history traits and morphology in Mus musculus. J. Exp. Biol., 204, 1937-1946.
6. Król, E., Johnson, M. S., & Speakman, J. R. (2003). Limits to sustained energy intake VIII. Resting metabolic rate and organ morphology of laboratory mice lactating at thermoneutrality. J. Exp. Biol., 206, 4283-4291.
7. Kunnecke, B., Verry, P., Benardeau, A., & von Kienlin M. (Oct 2004). Quantitative body composition analysis in awake mice and rats by Magnetic Resonance Relaxometry. Obes. Res., 12(10), 1604-1615.
8. Looije, N. A., Risovic, V., Stewart, D. J., Debeyer, D., Kutney, J., & Wasan, K. M. (2005). Disodium ascorbyl phytostanyl phosphates (FM-VP4) reduces plasma cholesterol concentration, body weight and abdominal fat gain within a dietary-induced obese mouse model. J. Pharm. Pharmaceut. Sci., 8(3), 400-408.
9. Miksa, I. R., Buckley, C. L., & Poppenga, R. H. (2004). Detection of nonesterified (free) fatty acids in bovine serum: comparative evaluation of two methods. J. Vet. Invest., 16, 139-144.
10. Selman, C., Lumsden, S., Bunger, L., Hill, W. G., Speakman J. R., Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake. J. Exp. Biol., 204, 777-784.
11. Speakman, J. R. (2005). Body size, energy metabolism and lifespan. J. Exp. Biol., 208, 1717-1730.
12. Wasan, K. M., & Looije, N. A. (2005). Emerging pharmacological approaches to the treatment of obesity. J. Pharm. Pharmaceut. Sci., 8(2), 259-271.
13. Wasan, K. M., Najafi, S., Peteherych, K. D., & Pritchard, P. H. (2001). Effects of a novel hydrophicil phytostanol analog on plasma lipid concentrations in gerbils. J. Pharm. Res., 90, 1795-1799.
14. Wasan, K. M., Najafi, S., Wong, J., Kwong, M., & Pritchard, H. (2001). Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils. J. Pharm. Pharmaceut. Sci., 4(3), 228-234.