Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate

National Medical Journal of China

Volumn 87, Issue 29, 2007, Pages 2033-2035

  Sun, Yan Ping ^a   Tan, Lan ^a   Wang, Yan ^a   Song, Jing Hui ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Glucuronosyltransferase; Pharmacokinetics; Polymorphism; Valproic acid

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A6; VALPROIC ACID;

ADOLESCENT; ADULT; ALLELE; ANTICONVULSANT THERAPY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHILD; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; EPILEPSY; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STANDARDIZATION;

ADOLESCENT; ADULT; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; EPILEPSY; GENE FREQUENCY; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; VALPROIC ACID; YOUNG ADULT;

EID: 35649002043     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Ferraro TN, Buono RJ. The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overview. Epilepsy Behav, 2005, 7: 18-36.
2. Nagar S, Zalatoris JJ, Blanchard RL. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics, 2004, 14:487-499.
3. Krishnaswamy S, Hao Q, Al-Rohaimi A. UDP glacuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5′-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation. J Pharmacol Exp Ther, 2005, 313: 1331-1339.
4. Krishnaswamy S, Hao Q, Al-Rohaimi A. UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (STA, T181A, and R184S). J Pharmacol Exp Ther, 2005, 313: 1340-1346.
5. Saeki M, Saito Y, Jinno H. Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab Pharmacokinet, 2005, 20:85-90.