Stereoselective determination of hydroxychloroquine and its major metabolites in human urine by solid-phase microextraction and HPLC

Journal of Separation Science

Volumn 30, Issue 15, 2007, Pages 2351-2359

  de Oliveira, Anderson Rodrigo Moraes ^a   Bonato, Pierina Sueli ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Enantiomeric separation; Hydroxychloroquine; Metabolites; Solid phase microextraction; Urine

Indexed keywords

ENANTIOMERIC SEPARATION; HYDROXYCHLOROQUINE; SOLID-PHASE MICROEXTRACTION; URINE;

DESORPTION; ENANTIOMERS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; METHANOL;

STEREOSELECTIVITY;

ALCOHOL; AMITRIPTYLINE; ATENOLOL; BUFFER; CAFFEINE; CARBAMAZEPINE; CHLORDIAZEPOXIDE; CHLOROQUINE; DEETHYLCHLOROQUINE; DEETHYLHYDROXYCHLOROQUINE; DIETHYLAMINE; DIPYRONE; DRUG METABOLITE; ETHOSUXIMIDE; FLUOXETINE; HALOPERIDOL; HEXANE; HYDROXYCHLOROQUINE; MEFLOQUINE; METHANOL; METHOTREXATE; MIRTAZAPINE; PHENACETIN; PHENYLBUTAZONE; PHENYLEPHRINE; PHOSPHATE; SALBUTAMOL; SALICYLIC ACID; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; DRUG DERIVATIVE;

ACCURACY; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; DESORPTION; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; ENANTIOMER; ENANTIOSELECTIVITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LINEAR SYSTEM; NORMAL HUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SOLID PHASE MICROEXTRACTION; STEREOCHEMISTRY; TEMPERATURE MEASUREMENT; TIME; URINARY EXCRETION; CALIBRATION; CHEMICAL MODEL; CHEMISTRY; CHROMATOGRAPHY; METABOLISM; METHODOLOGY; PH; REPRODUCIBILITY; SOLID PHASE EXTRACTION; STEREOISOMERISM; TEMPERATURE; URINE;

CALIBRATION; CHEMISTRY, ANALYTICAL; CHLOROQUINE; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYCHLOROQUINE; METHANOL; MODELS, CHEMICAL; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; STEREOISOMERISM; TEMPERATURE; TIME FACTORS;

EID: 35649000447     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700121     Document Type: Article

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