Transcranial ultrasound in acute stroke: From diagnosis to therapy

Cerebrovascular Diseases

Volumn 24, Issue SUPPL. 1, 2007, Pages 1-6

  Molina, Carlos A ^a   Alexandrov, Andrei V ^b  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Recanalization thrombolysis; Stroke diagnosis; Stroke therapy; Transcranial Doppler ultrasound

Indexed keywords

FIBRIN; PLACEBO; SHU 508; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ACUTE DISEASE; BLOOD CLOT LYSIS; BRAIN BLOOD FLOW; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONFERENCE PAPER; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFUSION WEIGHTED IMAGING; DOPPLER ECHOGRAPHY; ECHOENCEPHALOGRAPHY; FIBRINOLYTIC THERAPY; HEMODYNAMICS; HUMAN; MIDDLE CEREBRAL ARTERY OCCLUSION; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RECANALIZATION; STROKE; SYSTEMIC THERAPY;

ACUTE DISEASE; HUMANS; STROKE; THROMBOLYTIC THERAPY; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 35648987083     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107373     Document Type: Conference Paper

References (33)

1. Molina CA, Alexandrov AV, Demchuk AM, Saqqur M, Uchino K, Alvarez-Sabin J, CLOTBUST Investigators: Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 2004;35:151-156.
2. Demchuk AM, Burgin WS, Christou I, Felberg RA, Barber PA, Hill MD, Alexandrov AV: Thrombolysis in Brain Ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 2001;32: 89-93.
3. Burgin WS, Malkoff M, Demchuk AM, Felberg RA, Christou I, Grota JC, Alexandrov AV: Transcranial Doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke. Stroke 2000;31:1128-1132.
4. Alexandrov AV, Burgin SW, Demchuk AM, El-Mitwalli A, Grotta JC: Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement. Circulation 2001;103:2897-2902.
5. Christou I, Alexandrov AV, Burgin WS, Wojner AW, Felberg RA, Malkoff M, Grotta JC: Timing of recanalization after tissue plasminogen activator therapy determined by transcranial Doppler correlates with clinical recovery from ischemic stroke. Stroke 2000;31:1812-1816.
6. Blinc A, Planinsic G, Keber D, Jarh O, Lahajnar G, Zidansek A, Demsar F: Dependence of blood clot lysis on the mode of transport of urokinase into the clot: a magnetic resonance imaging study in vitro. Thromb Haemost 1991;65:549-552.
7. Blinc A, Keber D, Lahajnar G, Stegnar M, Zidansek A, Demsar F: Lysing patterns of retracted blood clots with diffusion or bulk flow transport of plasma with urokinase into clots: a magnetic resonance imaging study in vitro. Thromb Haemost 1992;68:667-671.
8. Blinc A, Francis CW: Transport processes in fibrinolysis and fibrinolytic therapy. Thromb Haemost 1996;76:481-491.
9. Linfante I, Llinas RH, Selim M, Chaves C, Kumar S, Parker RA, Caplan LR, Schlaug G: Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator. Stroke 2002;33:2066-2071.
10. Molina CA, Montaner J, Arenillas JF, Ribó M, Rubiera M, Alvarez-Sabín J: Differential pattern of tPA-induced proximal MCA recanalization among stroke subtypes. Stroke 2004;35:486-490.
11. Ribo M, Alvarez-Sabin J, Montaner J, Romero F, Delgado P, Rubiera M, Delgado-Mederos R, Molina CA: Temporal profil of recanalization after intravenous tissue plasminogen activator. Selecting patients for rescue reperfusion techniques. Stroke 2006;37:1000-1004.
12. Delgado-Mederos R, RibóM, Alvarez-Sabín J, Rovira A, Munuera J, Rubiera M, Santamarina E, Maisterra O, Delgado P, Montaner J, Molina CA: Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke. Stroke 2007;38:955-960.
13. Higashida RT, Furlan AJ: Trial design and reporting standards for intra-arterial thrombolysis for acute ischemic stroke. Stroke 2003;34:e109-e137.
14. Alvarez-Sabin J, Molina CA, Ribo M, Arenillas JF, Montaner J, Huertas R, Santamarina E, Rubiera M: Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion. Stroke 2004;35:2493-2498.
15. Burgin WS, Alexandrov AV: Deterioration following improvement with tPA therapy: carotid thrombosis and reocclusion. Neurology 2001;56:568-570.
16. Grotta JC, Welch KM, Fagan SC, Lu M, Frankel MR, Brott T, Levine SR, Lyden PD: Clinical deterioration following improvement in the NINDS rt-PA Stroke Trial. Stroke 2001;32:661-668.
17. Alexandrov AV, Grotta JC: Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology 2002;59:862-867.
18. Rubiera M, Alvarez-Sabin J, Ribo M, Montaner J, Santamarina E, Arenillas JF, Huertas R, Delgado P, Purroy F, Molina CA: Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke. Stroke 2005;36:1452-1456.
19. El-Mitwalli A, Saad M, Christou I, Malkoff M, Alexandrov AV: Clinical and sonographic pattern of tandem internal carotid artery/middle cerebral artery occlusion in tissue plasminogen activator-treated patients. Stroke 2002;33:99-102.
20. Christou I, Felberg RA, Demchuk AM, Burgin WS, Malkoff M, Grotta JC, Alexandrov AV: Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion. J Neuroimaging 2002;12:119-123.
21. Kim YS, Garami Z, Mikulik R, Molina CA, Alexandrov AV, for the CLOTBUST Collaborators: Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion. Stroke 2005;36:869-871.
22. Rubiera M, Ribo M, Delgado-Mederos R, Santamarina E, Delgado P, Montaner J, Alvarez-Sabin J, Molina CA: Tandem internal carotid artery/middle cerebral artery occlusion: an independent predictor of poor outcome after systemic thrombolysis. Stroke 2006;37:2301-2305.
23. Daffertshofer M, Hennerici M: Ultrasound in the treatment of ischemic stroke. Lancet Neurol 2003;2:283-290.
24. Eggers J, Koch B, Meyer K, Konig I, Seidel G: Effect of ultrasound on thrombolysis of middle cerebral artery occlusion. Ann Neurol 2003;53:797-800.
25. Alexandrov AV, Molina CA, Grotta JC, Garami Z, Ford SR, Alvarez-Sabin J, Montaner J, Saqqur M, Demchuk AM, Moyé LA, Hill MD, Wojner AW, for the CLOTBUST Investigators: Ultrasound-enhanced thrombolysis for acute ischemic stroke. N Engl J Med 2004;351:2170-2178.
26. Daffertshofer M, Gass A, Ringleb P, Sitzer M, Sliwka U, Els T, Sedlaczek O, Koroshetz WJ, Hennerici MG: Transcranial low-frequency ultrasound-mediated thrombolysis in brain: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator. Stroke 2005;36:1441-1446.
27. Dijkmans PA, Juffermans LJM, Musters RJP, van Wamel A, ten Cate FJ, van Gilst W, Visser CA, de Jong N, Kamp O: Microbubbles and ultrasound: from diagnosis to therapy. Eur J Echocardiography 2004;5: 245-256.
28. Tachibana K, Tachibana S: Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 1995;92:1148-1150.
29. Culp WC, Porter TR, Lowery J, Xie F, Robertson PK, Marky L: Intracranial clot lysis with intravenous microbubbles and transcranial ultrasound in swine. Stroke 2004;35:2407-2411.
30. Xie F, Tsutsui JM, Lof J, Unger EC, Johanning J, Culp WC, Matsunaga T, Porter TR: Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis. Ultrasound Med Biol 2005;31:979-985.
31. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R: Therapeutic applications of microbubbles. Eur J Radiol 2002;42:160-168.
32. Cintas P, Nguyen F, Boneu B, Larrue V: Enhancement of enzymatic fibrinolysis with 2-MHz ultrasound and microbubbles. J Thromb Haemost 2004;2:1163-1166.
33. Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, Arenillas JF, Purroy F, Delgado P, Alvarez-Sabín J: Microbubbles administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tPA. Stroke 2006;37:425-429.