메뉴 건너뛰기




Volumn 4, Issue 4, 2007, Pages 261-264

From head to tail: Microwave-assisted synthesis of Para hydrazine nicotinamide phenylalanine8-oxytocin derivatives

Author keywords

Conjugate; HYNIC; Libraries; Microwave; Oxytocin; Peptide

Indexed keywords


EID: 35648981034     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017807781024246     Document Type: Article
Times cited : (1)

References (20)
  • 1
    • 0021818675 scopus 로고
    • Smith, G. P. Science, 1985, 228, 1315.
    • (1985) Science , vol.228 , pp. 1315
    • Smith, G.P.1
  • 12
    • 35649021238 scopus 로고    scopus 로고
    • Nα-(9-Fluorenylmethoxycarbonyl)-p-nitro-L-phenylalanine (2) p-nitro-L-phenylalanine (1.0g, 4.73 mmol) was dissolved in a mixture of Dioxane (5 mL) and 10% Na2CO3 solution (10 mL, The solution temperature was lowered at 0 °C and 9-Fluorenylmethyl chloroformate (1.68 g, 1.05 equiv, in Dioxane (5 mL) was slowly added. Reaction flask was flushed with Nitrogen, sealed and reaction was allowed to stand overnight. Solution was concentrated under reduced pressure, DI water was added (10mL) and pH adjusted to 2.0 by addition of HCl conc. giving the formation of solids. Solids were filtered out and then taken into Ethyl Acetate (200 mL) upon heating and washed with DI water (2x 200 mL, Organic phase was dried with Na2SO4, filtered, solvent evaporated and solids dried under vacuum yielding 1.58 g (85, of a light yellow solid. m.p.=255°C 1H NMR (200 MHz, DMSO-d6) 8.0(d, 2H, J= 8.4 Hz, arom, 7.8d, 2H,J, 8.4 Hz
    • 6: C, 72.07; H, 6.05; N, 4.94. Found: C, 71.95; H, 6.12; N, 500.
  • 14
    • 35649008355 scopus 로고    scopus 로고
    • Microwave assisted reactions were carried out in a Microwave Accelerated Reaction System, Mars X, Version 047928, CEM corporation. Reaction conditions are: Swelling, 1 pulse of 120 sec at 15W; Coupling, 4 pulses of 15 sec at 100 W; Capping, 3 pulses of 30 see at 75 W; Deprotection, 3 pulses of 30 see at 75W. Cooling was applied after each pulse to keep reaction temperature below 60°C.
    • Microwave assisted reactions were carried out in a Microwave Accelerated Reaction System, Mars X, Version 047928, CEM corporation. Reaction conditions are: Swelling, 1 pulse of 120 sec at 15W; Coupling, 4 pulses of 15 sec at 100 W; Capping, 3 pulses of 30 see at 75 W; Deprotection, 3 pulses of 30 see at 75W. Cooling was applied after each pulse to keep reaction temperature below 60°C.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.