A randomized Phase I study of Atuna racemosa: A potential new anti-MRSA natural product extract

Journal of Ethnopharmacology

Volumn 114, Issue 3, 2007, Pages 371-376

  Buenz, Eric J ^a   Bauer, Brent A ^b   Schnepple, David J ^a   Wahner Roedler, Dietlind L ^b   Vandell, Alexander G ^b   Howe, Charles L ^c  

^a BioSciential LLC   (United States)

^b Mayo Clinic   (United States)

^c Molecular Medicine Program   (United States)

Author keywords

Antibacterial; MRSA; Natural product; Phase I; Plant; Samoa

Indexed keywords

ATUNA RACEMOSA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ANALYTIC METHOD; ANTIBACTERIAL ACTIVITY; ARTICLE; ATUNA RACEMOSA; BACTERIAL INFECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG SENSITIVITY; FEMALE; HUMAN; MALE; MEDICINAL PLANT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MAXIMUM TOLERATED DOSE; METHICILLIN RESISTANCE; PLANT EXTRACTS; ROSACEAE; STAPHYLOCOCCUS AUREUS;

ATUNA RACEMOSA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; THYRSITES ATUN;

EID: 35648976589     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.08.027     Document Type: Article

References (18)

1. Appelbaum P.C. The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. Clinical Microbiology and Infection 12 (2006) 16-23
2. Appelbaum P.C. MRSA-the tip of the iceberg. Clinical Microbiology and Infection 12 (2006) 3-10
3. Buenz E.J. Drug discovery from historic herbal texts. In: Ekins S. (Ed). Computer Applications in Pharmaceutical Research and Development (2006), John Wiley & Sons, Indianapolis
4. Buenz E.J. Hepatocytes detoxify Atuna racemosa extract. Experimental Biology and Medicine (Maywood) 231 (2006) 1739-1743
5. Buenz E.J. A high-throughput cell-based toxicity analysis of drug metabolites using flow cytometry. Cell Biology and Toxicology 23 (2007) 361-365
6. Buenz E.J. Mitochondrial involvement in Atuna racemosa induced toxicity. Journal of Ethnopharmacology 109 (2007) 304-311
7. Buenz E.J., Bauer B.A., Johnson H.E., Tavana G., Beekman E.M., Frank K.L., and Howe C.L. Searching historical herbal texts for potential new drugs. British Medical Journal 333 (2006) 1314-1315
8. Buenz E.J., Johnson H.E., Beekman E.M., Motley T.J., and Bauer B.A. Bioprospecting Rumphius's Ambonese herbal: volume I. Journal of Ethnopharmacology 96 (2005) 57-70
9. Buenz E.J., Limburg P.J., and Howe C.L. A high-throughput 3-parameter flow cytometry-based cell death assay. Cytometry A 71 (2007) 170-173
10. Buenz E.J., Schnepple D.J., Bauer B.A., Elkin P.L., Riddle J.M., and Motley T.J. Techniques: bioprospecting historical herbal texts by hunting for new leads in old tomes. Trends in Pharmacological Sciences 25 (2004) 494-498
11. Buenz E.J., Tillner Jr. J.E., Limburg P., and Bauer B.A. Antibacterial properties and toxicity of Atuna racemosa extract depend on kernel maturity. Journal of Ethnopharmacology 111 (2007) 592-597
12. Howden B.P., and Grayson M.L. Dumb and dumber-the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus. Clinical Infectious Diseases 42 (2006) 394-400
13. Koehn F.E., and Carter G.T. The evolving role of natural products in drug discovery. Nature Reviews Drug Discovery 4 (2005) 206-220
14. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. (2003), National Committee for Clinical Laboratory Standards, Wayne, PA
15. Prance G. The uses of Atuna racemosa Raf (Chrysobalanaceae) in Samoa. Economic Botany 58 (2004) 470-475
16. Ridenour G.A., Wong E.S., Call M.A., and Climo M.W. Duration of colonization with methicillin-resistant Staphylococcus aureus among patients in the intensive care unit: implications for intervention. Infection Control and Hospital Epidemiology 27 (2006) 271-278
17. Rumphius G. Herbarium Amboinense (1741-1755), Johannes Burman
18. Schnepple D., Bauer B., and Buenz E. The future of phytopharmaceutical discovery. In: Teixera da Silva (Ed). Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues (2006), Global Science Books, London 370-372