Failure to achieve a threshold dose of CD34+CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation

Bone Marrow Transplantation

Volumn 40, Issue 9, 2007, Pages 851-857

  Sartor, M M ^a   Garvin, F ^a   Antonenas, V ^a   Bradstock, K F ^a   Gottlieb, D J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CARBOPLATIN; CARMUSTINE; CD34 ANTIGEN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; MELPHALAN; THIOTEPA; THROMBOPOIETIN RECEPTOR; VINCRISTINE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; CHILD; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG MEGADOSE; ENGRAFTMENT; FLOW CYTOMETRY; HUMAN; MONOTHERAPY; PATIENT IDENTIFICATION; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THROMBOCYTE TRANSFUSION;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD34; BLOOD PLATELETS; CELL COUNT; CHILD; CHILD, PRESCHOOL; DELAYED GRAFT FUNCTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; MIDDLE AGED; PLATELET COUNT; PLATELET TRANSFUSION; RECEPTORS, THROMBOPOIETIN; RETROSPECTIVE STUDIES; ROC CURVE; TRANSPLANTATION, AUTOLOGOUS;

EID: 35648975265     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705818     Document Type: Article

References (14)

1. Meldgaard Knudsen L, Jensen L, Jarlbaek L, Hansen PG, Hansen SW, Drivsholm L et al. Subsets of CD34+ hematopoietic progenitors and platelet recovery after high dose chemotherapy and peripheral blood stem cell transplantation. Haematologica 1999; 84: 517-524.
2. Nash RA, Gooley T, Davis C, Appelbaum FR. The problem of thrombocytopenia after hematopoietic stem cell transplantation. Stem Cells 1996; 14 (Suppl 1): 261-273.
3. Ramsfjell V, Borge OJ, Cui L, Jacobsen SE. Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and fit3, and inhibitory effects of TGF-beta and TNF-alpha. J Immunol 1997; 158: 5169-5177.
4. Kaushansky K. Thrombopoietin: The primary regulator of megakaryocyte and platelet production. Thromb Haemost 1995; 74: 521-525.
5. Sartor M, Antonenas V, Garvin F, Webb M, Bradstock KF. Recovery of viable CD34+ cells from cryopreserved hemopoietic progenitor cell products. Bone Marrow Transplant 2005; 36: 199-204.
6. Gratama JW, Kraan J, Keeney M, Sutherland DR, Granger V, Barnett D. Validation of the single-platform ISHAGE method for CD34(+) hematopoietic stem and progenitor cell enumeration in an international multicenter study. Cytotherapy 2003; 5: 55-65.
7. Altman DG, BlRnd JM. Statistics notes: Diagnostic test 3: receiver operating characteristic plots. Br Med J 1994; 309: 188.
8. Crowther H, Collins D, Antonenas V, McGurgan M, Kerridge I, Gottlieb D et al. Successful autologous peripheral blood stem cell harvest and transplant in a patient with cold agglutinins. Bone Marrow Transplant 2006; 37: 329-330.
9. Weaver CH, Hazelton B, Birch R, Palmer P, Allen C, Schwartzberg L et al. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood 1995; 86: 3961-3969.
10. Millar BC, Millar JL, Shepherd V, Blackwell P, Porter H, Cunningham D et al. The importance of CD34+/CD33- cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue. Bone Marrow Transplant 1998; 22: 469-475.
11. Robinson SN, Freedman AS, Neuberg DS, Nadler LM, Mauch PM. Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict poor engraftment. Exp Hematol 2000; 28: 1325-1333.
12. Dercksen MW, Rodenhuis S, Dirkson MK, Schaasberg WP, Baars fW, van der Wall E et al. Subsets of CD34 + cells and rapid hematopoietic recovery after peripheral-blood stem-cell transplantation. J Chn Oncol 1995; 13: 1922-1932.
13. Feng R, Shimazaki C, Inaba T, Takahashi R, Hirai H, Kikuta T et al. CD34+/CD41a+ cells best predict platelet recovery after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1998; 21: 1217-1222.
14. Maharaj D, Steinberg JP, Gouvea JV, Gieser PW. Changes in endogenous TPO levels during mobilization chemotherapy are predictive of CD34 + megakaryocyte progenitor yield and identify patients at risk of delayed platelet engraftment post-PBPC transplant. Bone Marrow Transplant 1999; 23: 539-548.