Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast

Biochemical and Biophysical Research Communications

Volumn 364, Issue 3, 2007, Pages 573-577

  Lo, Chor Wai ^a,b   Kaida, Daisuke ^a   Nishimura, Shinichi ^a   Matsuyama, Akihisa ^a   Yashiroda, Yoko ^a   Taoka, Hiroshi ^a   Ishigami, Ken ^b   Watanabe, Hidenori ^b   Nakajima, Hidenori ^c   Tani, Tokio ^d   Horinouchi, Sueharu ^b   Yoshida, Minoru ^a,e  

^a RIKEN   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Fission yeast; Pre mRNA; Pre mRNA retention; SF3b; Spliceostatin A; Splicing

Indexed keywords

FUNGAL PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; SPLICEOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FUNGAL STRAIN; GENE OVEREXPRESSION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RNA BINDING; RNA SPLICING; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SPLICEOSOME; STRUCTURAL HOMOLOGY;

CELL NUCLEUS; FUNGAL PROTEINS; RNA PRECURSORS; RNA SPLICING; SACCHAROMYCES; SPLICEOSOMES;

MAMMALIA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCETACEAE;

EID: 35648965653     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.029     Document Type: Article

References (16)

1. Kramer A. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem. 65 (1996) 367-409
2. Galy V., Gadal O., Fromont-Racine M., Romano A., Jacquier A., and Nehrbass U. Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116 (2004) 63-73
3. Dziembowski A., Ventura A.P., Rutz B., Caspary F., Faux C., Halgand F., Laprevote O., and Seraphin B. Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J. 23 (2004) 4847-4856
4. Carneiro T., Carvalho C., Braga J., Rino J., Milligan L., Tollervey D., and Carmo-Fonseca M. Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus. Mol. Cell. Biol. 27 (2007) 4157-4165
5. Kaida D., Motoyoshi H., Tashiro E., Nojima T., Hagiwara M., Ishigami K., Watanabe H., Kitahara T., Yoshida T., Nakajima H., Tani T., Horinouchi S., and Yoshida M. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat. Chem. Biol. 3 (2007) 576-583
6. Nakajima H., Hori Y., Terano H., Okuhara M., Manda T., Matsumoto S., and Shimomura K. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J. Antibiot. (Tokyo) 49 (1996) 1204-1211
7. Nakajima H., Sato B., Fujita T., Takase S., Terano H., and Okuhara M. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J. Antibiot. (Tokyo) 49 (1996) 1196-1203
8. Motoyoshi H., Horigome M., Ishigami K., Yoshida T., Horinouchi S., Yoshida M., Watanabe H., and Kitahara T. Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes. Biosci. Biotechnol. Biochem. 68 (2004) 2178-2182
9. + gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe. RNA 7 (2001) 671-681
10. Habara Y., Urushiyama S., Tani T., and Ohshima Y. The fission yeast prp10(+) gene involved in pre-mRNA splicing encodes a homologue of highly conserved splicing factor, SAP155. Nucleic Acids Res. 26 (1998) 5662-5669
11. Nishi K., Yoshida M., Nishimura M., Nishikawa M., Nishiyama M., Horinouchi S., and Beppu T. A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins. Mol. Microbiol. 6 (1992) 761-769
12. Chen X.Q., Du X., Liu J., Balasubramanian M.K., and Balasundaram D. Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis. Yeast 21 (2004) 495-509
13. Strambio-de-Castillia C., Blobel G., and Rout M.P. Proteins connecting the nuclear pore complex with the nuclear interior. J. Cell. Biol. 144 (1999) 839-855
14. Shibata S., Matsuoka Y., and Yoneda Y. Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells. Genes Cells 7 (2002) 421-434
15. Spadaccini R., Reidt U., Dybkov O., Will C., Frank R., Stier G., Corsini L., Wahl M.C., Luhrmann R., and Sattler M. Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA 12 (2006) 410-425
16. Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., and Gould K.L. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol. Cell. Biol. 22 (2002) 2011-2024