Selective synthesis and utility of one tripyrrolic compound and its intermediates

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 10, 2007, Pages 1439-1441

  Wang, Haiyong ^a   Chen, Min ^b   Wang, Lin ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b Beijing Neuron Applied Technology R and D Co   (China)

Author keywords

Aldehyde; Heterocycle; Histone deacetylase inhibitor (HDACI); Pyrrole; Simple procedure

Indexed keywords

2,4 DIMETHYL 3 CARBETHOXYPYRROLE; ALDEHYDE; HISTONE DEACETYLASE INHIBITOR; PHA 665752; PROTEIN TYROSINE KINASE INHIBITOR; PYRROLE; PYRROLE DERIVATIVE; RECEPTOR BLOCKING AGENT; SCATTER FACTOR RECEPTOR; SU 11274; SUNITINIB; TRI(2,4 DIMETHYL 3 CARBETHOXYPYRROLYL) METHANE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DECARBOXYLATION; DRUG STRUCTURE; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; TECHNIQUE;

CELL LINE; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN-TYROSINE KINASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TIME FACTORS;

EID: 35648949908     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1439     Document Type: Article

References (20)

1. Dalat V., Aust. J. Chem., 29, 1561-1571 (1976).
2. Clewlow P. J., Jackson A. H., J. Chem. Soc. Perkin Trans. 1, 1990, 1925-1936 (1990).
3. Clezy P. S., Aust. J. Chem., 44, 1163-1193 (1991).
4. Clezy P. S., Salek A., Aust. J. Chem., 49, 265-272 (1996).
5. Faivre S., Delbaldo C., Vera K., Robert C., Lozahic S., Lassau N., Bello C., Deprimo S., Brega N., Massimini G., Armand J., Scigalla P., Raymond E., J. Clin. Oncol., 24, 25-35 (2006).
6. Kouraklis G., Theocharis S., Oncol. Rep., 15, 489-494 (2006).
7. Michaud N. R., Expert Opin. Ther. Pat., 15, 621-625 (2005).
8. Silverstein R. M., Ryskiewicz E. E., Willard C., Koehler R. C., J. Org. Chem., 20, 668-672 (1955).
9. Candy C. F., Jones R. A., Wright P. H., J. Chem. Soc. (C), 1970, 2563-2566 (1970).
10. Treibs A., Schmidt R. A., Zinsmeister R., Chem. Ber., 90, 79-84 (1957).
11. Cui J. R., Ramphal Y., Liang C. X., WO 02/096361 (2002) [Chem. Abstr., 138, 14005 (2003)].
12. Wang H. Y., Wang L., Chemistry, 69, 611-614 (2006).
13. Clezy P. S., Crowley R. J., Hai T. T., Aust. J. Chem., 35, 411-421 (1982).
14. Ayabe M., Yamashita K., Sada K., J. Org. Chem., 68, 1059-1066 (2003).
15. Ghosh A. K., Mathivanan P., Coppiello J., Tetrahedron: Asymmetry, 9, 1-45 (1998).
16. Paine J. B., III, Woodward R. B., J. Org. Chem., 41, 2826-2835 (1976).
17. Clezy P. S., Crowley R. J., Hai T. T., Aust. J. Chem., 35, 411-421 (1982).
18. Fox O. D., Rolls T. D., Beer P. D., Drew M. G. B., Chem. Commun., 17, 1632-1633 (2001).
19. Won D.-H., Lee C.-H., Tetrahedron Lett., 44, 6695-6697 (2003).
20. Kéri G., Örfi L., Erös D., Hegymegi-Barakonyi B., Szántai-Kis C., Horváth Z., Wáczek F., Marosfalvi J., Szabadkai I., Pató J., Greff Z., Hafenbrad D., Daub H., Müller G., Kleb B., Ullrich A., Curr. Signal Transduction Ther., 1, 67-95 (2006).