The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation

Thrombosis Research

Volumn 121, Issue 1, 2007, Pages 67-73

  Gando, Satoshi ^a   Hayakawa, Mineji ^a   Sawamura, Atsushi ^a   Hoshino, Hirokatsu ^a   Oshiro, Akiko ^a   Kubota, Nobuhiko ^a   Jesmin, Subrina ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

D dimer; Disseminated intravascular coagulation (DIC); Fibrinolysis; Neutrophil elastase; Sepsis; Urinary trypsin inhibitor (UTI)

Indexed keywords

ANTITHROMBIN; D DIMER; FIBRIN; FIBRIN DEGRADATION PRODUCT; LEUKOCYTE ELASTASE; PLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; ULINASTATIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; ENZYME ACTIVATION; FEMALE; FIBRINOLYSIS; HUMAN; HUMAN CELL; MALE; MULTIPLE ORGAN FAILURE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; FIBRINOLYSIS; HUMANS; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSPECTIVE STUDIES; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 35648943673     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2007.02.010     Document Type: Article

References (24)

1. Levi M., and ten Cate H. Disseminated intravascular coagulation. N Engl J Med 341 (1999) 586-592
2. Plow E.F., and Edgington T.S. An alternative pathway for fibrinolysis: I. The cleavage of fibrinogen by leucocyte protease at physiologic pH. J Clin Invest 56 (1975) 30-38
3. Machovich R., and Owen W.G. The elastase-mediated pathway of fibrinolysis. Blood Coagul Fibrinolysis 1 (1990) 79-90
4. Weiss S.J. Tissue destruction by neutrophils. N Engl J Med 320 (1989) 365-376
5. Plow E.F. The major fibrinolytic proteases of human leucocytes. Biochim Biophys Acta 630 (1980) 47-56
6. Francis C.W., and Marder V.J. Degradation of cross-linked fibrin by human leucocyte proteases. J Lab Clin Med 107 (1986) 342-352
7. Kohno I., Inuzuka K., Itoh Y., Nakahara K., Eguchi Y., Sugo T., et al. A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma. Blood 95 (2000) 1721-1728
8. Pugia M.J., and Lott J.A. Pathophysiology and diagnostic value of urinary trypsin inhibitors. Clin Chem Lab Med 43 (2005) 1-16
9. Matsumoto T., Wada H., Nobori T., Nakatani K., Onishi K., Nishikawa M., et al. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation. Clin Appl Thromb Hemost 11 (2005) 391-400
10. Gando S., Kameue T., Matsuda N., Hayakawa M., Hoshino H., and Kato H. Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb Res 116 (2005) 91-100
11. Knaus W.A., Draper E.A., Wanger D.P., and Zimmerman J.E. APACHE II: a severity classification system. Crit Care Med 13 (1985) 818-829
12. Gando S, Sawamura A, Hayakawa M, Hoshino H, Kubota N, Nishihira J. High macrophage migration inhibitory factor levels in disseminated intravascular coagulation patients with systemic inflammatory response syndrome and sepsis. Inflammation in press.
13. Members of American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20 (1992) 864-874
14. Murray J.F., Matthay M.A., Luce J.M., and Flick M.R. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138 (1988) 720-723
15. Taylor Jr. F.B., Toh C.H., Hoot W.K., Wada H., and Levi M. Toward definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 86 (2001) 1327-1330
16. Hamano S., Tanaka S., Takeda Y., Umeda M., and Sakata Y. A novel monoclonal antibody to fibrin monomer and soluble fibrin for the detection of soluble fibrin in plasma. Clin Chim Acta 318 (2002) 25-32
17. Inoue K., Takano H., Shimada A., Yanagisawa R., Sakurai M., Yoshino S., et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Mol Pharmacol 67 (2005) 673-680
18. Gardinali M., Padalino P., Vesconi S., Calcagno A., Ciappellano S., Conciato L., et al. Complement activation and polymorphonuclear neutrophil leucocyte elastase in sepsis. Correlation with severity of disease. Arch Surg 127 (1992) 1219-1224
19. Neumann S., Gunzer G., Hennrich N., and Lang H. "PMN-elastase assay": enzyme immunoassay for human polymorphonuclear elastase complexed with alpha1-proteinase inhibitor. J Clin Chem Clin Biochem 22 (1984) 693-697
20. Wu B.K., Urano T., Ihara H., Takeda Y., Fujie M., Shikimori M., et al. The cleavage and inactivation of plasminogen activator inhibitor type 1 by neutrophil elastase: the evaluation of its physiologic relevance in fibrinolysis. Blood 86 (1995) 1056-1061
21. Bach-Gansmo E.T., Halvorsen S., Godal H.C., and Skjønsberg O.H. Impaired clot lysis in the presence of human neutrophil elastase. Thromb Res 80 (1995) 153-159
22. Moir E., Robbie L.A., Bennett B., and Booth N.A. Polymorphonuclear leucocytes have two opposing roles in fibrinolysis. Thromb Haemost 87 (2002) 1006-1010
23. Gando S, Kameue T, Sawamura A, Hayakawa M, Hoshino H, Kubota N. An alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass surgery and major abdominal surgery. Thromb Res (Epub ahead of print).
24. Kamikura Y., Wada H., Nobori T., Matsumoto T., Shiku H., Ishikura K., et al. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis. Thromb Res 115 (2005) 53-57