A study on the synthesis and biological and optical properties of methylene-dinaphthyl bis-chromanones: the utility of Baylis-Hillman adducts

Tetrahedron Letters

Volumn 48, Issue 48, 2007, Pages 8562-8565

  Rajan, Yeasudhasan Christu ^a   Kanakam, Charles Christopher ^a   Selvam, S Periyar ^b   Murugesan, K ^b  

^a PRESIDENCY COLLEGE   (India)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

Anti bacterial activity; Baylis Hillman adducts; Bis chromanones; Methylene dinaphthol; Photoluminescence

Indexed keywords

4 CHROMANONE DERIVATIVE; CARBROMAL; METHYLENE DINAPHTHYL BIS CHROMANONE DERIVATIVE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BAYLIS HILLMAN REACTION; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SAPONIFICATION; SYNTHESIS; ULTRAVIOLET SPECTROSCOPY;

BACTERIA (MICROORGANISMS);

EID: 35549002574     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.09.097     Document Type: Article

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25. 6. Anal. Calcd: C, 80.11; H, 5.00; found: C, 80.19; H, 4.92.
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29. Anti-bacterial activity: The test bacteria were sub-cultured in Muller-Hinton broth from which 1 ml of cell suspension was taken and the optical density was adjusted to 0.5, after which this was spread as a thin film over the Muller-Hinton agar plates. The synthetic compounds were loaded onto the discs at 50, 100 and 150 μg concentrations and air-dried. These were placed on the inoculated Muller-Hinton agar plates, and incubated at 37 °C for 48 h. After incubation, the zone of inhibition was measured. A streptomycin disc (10 μg/disc) was used as the standard. A disc of 150 μl of DMSO, served as the control.