Detection and treatment of akathisia in advanced cancer patients during adjuvant analgesic therapy with tricyclic antidepressants: Case reports and review of the literature

Palliative and Supportive Care

Volumn 5, Issue 4, 2007, Pages 411-414

  Onishi, Hideki ^a   Yamamoto, Wataru ^a   Wada, Makoto ^b   Nishida, Tomomi ^c   Wada, Mei ^d   Sunagawa, Yu ^a   Miya, Toshimichi ^a   Kawanishi, Chiaki ^e   Narabayashi, Masaru ^a   Sasaki, Yasutsuna ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Sakamoto Hospital   (Japan)

^d KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Akathisia; Cancer; Pain control; Tricyclic antidepressants

Indexed keywords

AMOXAPINE; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AKATHISIA; ARTICLE; BREAST TUMOR; CASE REPORT; DRUG COMBINATION; DRUG RESISTANCE; FEMALE; HUMAN; MALE; MIDDLE AGED; PAIN; PALLIATIVE THERAPY; PATHOPHYSIOLOGY; RECTUM TUMOR;

ADULT; AKATHISIA, DRUG-INDUCED; AMOXAPINE; ANALGESICS; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BREAST NEOPLASMS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PALLIATIVE CARE; RECTAL NEOPLASMS;

EID: 35548996704     PISSN: 14789515     EISSN: 14789523     Source Type: Journal    
DOI: 10.1017/S1478951507000612     Document Type: Article

References (21)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press.
2. Apiquian, R., Fresan, A., Ulloa, R.E., et al. (2005). Amoxapine as an atypical antipsychotic: A comparative study vs risperidone. Neuropsychopharmacology, 30, 2236-2244.
3. Atbaşǧlu, E.C., Schultz, S.K., & Andreasen, N.C. (2001). The relationship of akathisia with suicidality and depersonalization among patients with schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences, 13, 336-341.
4. Botney, M. & Fields, H.L. (1983). Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Annals of Neurology, 13, 160-164.
5. Dolton, P.T. (1981). Amoxapine: A newly marketed tricyclic antidepressant. Psychatric Annals, 11, 379-383.
6. Francis, J., Martin, D., & Kapoor, W.N. (1990). A prospective study of delirium in hospitalized elderly. JAMA, 263, 1097-1101.
7. Gibb, W.R. & Lees, A.J. (1986). The clinical phenomenon of akathisia. Journal of Neurology Neurosurgery and Psychiatry, 49, 861-866.
8. Hamon, M., Gozlan, H., Bourgoin, S., et al. (1987). Opioid receptors and neuropeptides in the in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology, 26, 531-539.
9. Hirose, S. (2000). Restlessness of respiration as a manifestation of akathisia: Five case reports of respiratory akathisia. Journal of Clinical Psychiatry, 61, 737-741.
10. Hirose, S. (2003). The causes of underdiagnosing akathisia. Schizophrenia Bulletin, 29, 547-558.
11. Hsin-Tung, E. & Simpson, G.M. (2000). Medication-induced movement disorders. In Comprehensive Textbook of Psychiatry, 7th ed., Sadock B. & Sadock V.A. (eds.). Philadelphia: Lippincott Williams & Wilkins.
12. Khawam, E.A., Laurencic, G., & Malone, D.A., Jr. (2006). Side effects of antidepressants: An overview. Cleveland Clinic Journal of Medicine, 73, 351-353.
13. Krishnan, K.R.R., France, R.D., & Ellinwood, E.H. (1984). Tricyclic-induced akathia in patients taking conjugated estrogens. American Journal of Psychiatry, 141, 696-697.
14. Magni, G., Conlon, P., & Arsie, D. (1987). Tricyclic anti-depressants in the treatment of cancer pain: A review. Pharmacopyschiatry, 20, 160-164.
15. Portenoy, R.K. (2001). Adjuvant analgesics in pain management. In Oxford Textbook of Palliatiue Medicine, Doyle, D., Hanks, G.W.C., & MacDonald, N. (eds.), pp. 361-390. Oxford, Oxford University Press.
16. Ratey, J.J. & Salzman, C. (1984). Recognizing and managing akathisia. Hospital Community Psychiatry, 35, 975-977.
17. Rodgers, C. (1992). Extrapyramidal side effects of antiemetics presenting as psychiatric illness. General Hospital Psychiatry, 14 192-195.
18. Sachdev, P. & Kruk, J. (1994). Clinical characteristics and predisposing factors in acute drug-induced akathisia. Archives of General Psychiatry, 51, 963-974.
19. Siris, S.G. (1985). Three cases of akathisia and "acting out." Journal of Clinical Psychiatry, 46, 395-397.
20. Shear, M.K., Frances, A., & Weiden, P. (1983). Suicide associated with akathisia and depot fluphenazine treatment. Journal of Clinical Psychopharmacology, 3, 235-236.
21. Walters, A.S., Hening, W., Chokroverty, S., et al. (1989). Restlessness of the arms as the principal manifestation of neuroleptic-induced akathisia. Journal of Neurology, 236, 435.