A hypothesis for how chromosome 11 translocations cause psychiatric disorders

Genetics

Volumn 177, Issue 2, 2007, Pages 1259-1262

  Singh, Gurjeet ^a   Klar, Amar J S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALG9 GENE; ARTICLE; CHROMOSOME 11; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CYTOGENETICS; GENE; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GENE SEGREGATION; GENETIC VARIABILITY; HUMAN; HYPOTHESIS; MENTAL DISEASE; PHENOTYPE; PRIORITY JOURNAL;

CHROMOSOMES, HUMAN, PAIR 11; GENE REARRANGEMENT; HUMANS; MENTAL DISORDERS; MODELS, GENETIC; TRANSLOCATION, GENETIC;

EID: 35548995772     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.107.077875     Document Type: Article

References (15)

1. ANONYMOUS, 2006 Human genetics in the Crescent City. Nat. Genet. 38: 1221.
2. ARMAKOLAS, A., and A. J. S. KLAR, 2006 Cell type regulates selective segregation of mouse chromosome 7 DNA strands in mitosis. Science 311: 1146-1149.
3. ARMAKOLAS, A., and A. J. S. KLAR, 2007 Left-right dynein motor implicated in selective chromatid segregation inmouse cells. Science 315: 100-101.
4. BAYSAL, B. E., J. E. WILLETT-BROZICK, S. A. BACANU, S. DETERA-WADLEIGH and V. L. NIMGAONKAR, 2006 Common variations in ALG9 are not associated with bipolar I disorder: a family-based study. Behav. Brain Funct. 2: 25-31.
5. JEFFRIES, A. R., A. J. MUNGALL, E. DAWSON, K. HALLS, C. F. LANGFORD et al., 2003 beta-1,3- Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation. Mol. Psychiatry 8: 654-663.
6. KLAR, A. J. S., 1987 Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast. Nature 326: 466-470.
7. KLAR, A. J. S., 1990 The developmental fate of fission yeast cells is determined by the pattern of inheritance of parental and grandparental DNA strands. EMBO J. 9: 1407-1415.
8. KLAR, A. J. S., 1994 A model for specification of the left-right axis in vertebrates. Trends Genet. 10: 392-396.
9. KLAR, A. J. S., 2002 The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders. Genetics 160: 1745-1747.
10. KLAR, A. J. S., 2003 Response to Millar et al.: critique of chromosome 1;11 translocation causing psychosis. Genetics 163: 837-838.
11. KLAR, A. J. S., 2004a A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases. Genetics 167: 1833-1840.
12. KLAR, A. J. S., 2004b An epigenetic hypothesis for human brain laterality, handedness and psychosis development. Cold Spring Harbor Symp. Quant. Biol. 69: 499-506.
13. KLAR, A. J. S., 2007 Lessons learned from studies of fission yeast mating-type switching and silencing. Ann. Rev. Genet. 41: 213-236.
14. MILLAR, J. K., P. A. THOMSON, N. R. WRAY, W. J. MUIR, D. H. BLACKWOOD et al., 2003 Response to Amar J. Klar: the chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders. Genetics 163: 833-835.
15. PICKARD, B. S., J. K. MILLAR, D. J. PORTEOUS, W. J. MUIR and D. H. BLACKWOOD, 2005 Cytogenetics and gene discovery in psychiatric disorders. Pharmacogenomics J. 5: 81-88.