Highly selective methanesulfonic acid-catalyzed 1,3-isomerization of allylic alcohols

Tetrahedron Letters

Volumn 48, Issue 48, 2007, Pages 8505-8507

  Leleti, Rajender Reddy ^a   Hu, Bin ^a   Prashad, Mahavir ^a   Repič, Oljan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

1,3 Isomerization; Allylic alcohols; Methanesulfonic acid; THF; Water

Indexed keywords

ALLYL ALCOHOL; ALLYL COMPOUND; MESYLIC ACID;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; ISOMERIZATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

EID: 35548987850     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.09.156     Document Type: Article

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15. 3 solution (10 mL). The resulting mixture was extracted with i-PrOAc (3× 10 mL). The combined organic layers were washed with water and concentrated under reduced pressure. The resulting crude product was purified by column chromatography (silica gel 230-400 mesh) using a gradient mixture of i-PrOAc and pentane to furnish pure allylic alcohol.
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