Congenital heart disease, maternal age and parental consanguinity in children with Down's syndrome;Cardiopathie congénitale, age maternel et consanguinité parentale chez les enfants avec syndrome de down

Journal Medical Libanais

Volumn 55, Issue 3, 2007, Pages 133-137

  Chéhab, Ghassan ^a,b,c   Chokor, Imad ^a   Fakhouri, Hassan ^a   Hage, Georges ^b   Saliba, Zakhia ^b   El Rassi, Issam ^b  

^a LEBANESE UNIVERSITY   (Lebanon)

^b SAINT JOSEPH UNIVERSITY   (Lebanon)

^c RAFIC HARIRI UNIVERSITY HOSPITAL   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHILD; COMPLETE HEART BLOCK; CONGENITAL HEART MALFORMATION; CONSANGUINEOUS MARRIAGE; CONSANGUINITY; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; HEART VENTRICLE SEPTUM DEFECT; HUMAN; INFANT; LEBANON; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; MEDICAL SOCIETY; RISK FACTOR; STATISTICAL SIGNIFICANCE; AGE; COMPARATIVE STUDY; ENDOCARDIAL CUSHION DEFECT; MIDDLE AGED; REGISTER; SEX DIFFERENCE;

ADULT; AGE FACTORS; CHILD; CONSANGUINITY; DOWN SYNDROME; ENDOCARDIAL CUSHION DEFECTS; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; LEBANON; MALE; MATERNAL AGE; MIDDLE AGED; REGISTRIES; RISK FACTORS; SEX FACTORS;

EID: 35548946316     PISSN: 00239852     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Stall C, Alembic Y, Dott B, Roth MP. Study of Down's syndrome in 238,942 consecutive births. Ann Genet 1998 ; 41 : 44-51.
2. Cereijo AI, Martinez-Frias ML. Consanguineous marriages among parents of patients with Down's syndrome. Clin Genet 1993;44:221-2.
3. Al-Arrayed SS. Review of the spectrum of genetic diseases in Bahrain. East Mediterr Health J 1999 ; 5 : 1114-20.
4. Ferencz C, Rubin JD, McCarter RJ et al. Congenital heart disease : prevalence at livebirth. The Baltimore-Washington Infant Study. Am J Epidemiol 1985 ; 121 : 31-6.
5. Iselius L, Lindsten J. Changes in the incidence of Down's syndrome in Sweden during 1968-1982. Hum Genet 1986 ; 72 : 133-9.
6. Alfi OS, Chang R, Azen SP. Evidence for genetic control of nondisjunction in man. Am J Hum Genet 1980 ; 32 : 477-83.
7. Moreno-Fuenmayor H, Champin J, Alvarez-Arratia M, Sanchez O. Epidemiology of congenital malformations in Bolivar City, Venezuela. Analysis of the consanguinity factor. Invest Clin 1993 ; 34 : 5-14.
8. Mokhtar MM, Abdel-Fattah M. Major birth defects among infants with Down's syndrome in Alexandria, Egypt (1995-2000). J Trop Pediatr 2002 ; 48 : 247-9.
9. Roberts DF, Roberts MJ, Johnston AW. Genetic epidemiology of Down's syndrome in Shetland. Hum Genet 1991 ; 87 : 57-60.
10. De Braekeleer M, Landry T, Cholette A. Consanguinity and kinship in Down's syndrome in Saguenay Lac-Saint-Jean (Quebec). Ann Genet 1994 ; 37 : 26-8.
11. Hook EB. Consanguinity and Down's syndrome in the Shetland Islands. Hum Genet 1992 ; 89 : 462.
12. Zlotogora J. Genetic disorders among Palestinian Arabs : 1. Effects of consanguinity. Am J Med Genet 1997 ; 68 : 472-5.
13. Devoto M, Prosperi L, Bricarelli FD et al. Frequency of consanguineous marriages among parents and grandparents of Down patients. Hum Genet 1985 ; 70 (3) : 256-8.
14. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiology 2002 ; 39 : 1890-900.
15. UNICEF. National Perinatal Research, Lebanon 1999-2000. UNICEF Lebanon 2002 : 4-6.
16. Khoury MJ, Erikson JD. Improved ascertainment of cardiovascular malformations in infants with Down's syndrome, Atlanta, 1968 through 1989. Implications for the interpretation of increasing rates of cardiovascular malformations in surveillance systems. Am J Epidemiol 1992 ; 136 : 1457-64.
17. Freeman SB, Taft LF, Dooley KJ et al. Population-based study of congenital heart defects in Down's syndrome. Am J Med Genet 1998 ; 80 : 213-17.
18. Venugopalan P, Agarwal AK. Spectrum of congenital heart defects associated with Down's syndrome in high consanguineous Omani population. Indian Pediatr 2003 ; 40 : 398-403.
19. Wells GL, Barker SE, Finley SC, Colvin EV, Finley WH. Congenital heart disease in infants with Down's syndrome. South Med J 1994 ; 87 : 724-7.
20. Carothers AD, Castilla EE, Dutra MG, Hook EB. Search for ethnic, geographic, and other factors in the epidemiology of Down's syndrome in South America : analysis of data from the ECLAMC project, 1967-1997. Am J Med Genet 2001 ; 103 : 149-56.
21. De Grouchy J, Turleau C : Atlas des maladies chromosomiques, Seconde Edition, Paris : Expansion Scientifique, 1982 : 340-51.
22. Zahed L, Megarbane A. A cytogenetic register of Down's Syndrome in Lebanon. Community Genet 1998 ; 1 (2) : 84-9.
23. El Hazmi M, Swailem A. Consanguinity among the Saudi Arabian population. J Med Genet 1995 ; 32 : 23-6.
24. Rittler M, Liascovich R, Lopez-Camelo J, Castilla EE. Parental consanguinity in specific types of congenital anomalies. Am J Med Genet 2001 ; 102 : 36-43.
25. Hamamy HA, Al-Hakkak ZS, Al-Taha S. Consanguinity and the genetic control of Down's syndrome. Clin Genet 1990 ; 37 : 24-9.
26. Basaran N, Cenani A, Sayli BS et al. Consanguineous marriages among parents of Down patients. Clin Genet 1992 ; 42 : 13-15.
27. Sayee R, Thomas IM. Consanguinity, non-disjunction, parental age and Down's syndrome. J Indian Med Assoc 1998 ; 96 : 335-7.
28. Tennstedt C, Chaoui R, Komer H, Dietel M. Spectrum of congenital heart defects and extracardiac malformations associated with chromosomal abnormalities : results of a seven-year necropsy study. Heart 1999 ; 82 : 34-9.
29. Stoll C, Alembik Y, Dott B, Roth MP. Epidemiology syndrome in 118,265 consecutive births. Am J Med Genet 1990 ; 7 (Suppl) : 79-83.
30. Khoury MJ, Erikson JD. Can maternal risk factors influence the presence of major birth defects in infants with Down's syndrome ? Am J Med Genet 1992 ; 43 (6) : 1016-22.