Preventing type 2 diabetes and cardiovascular disease in metabolic syndrome: The role of PPARα

Diabetes and Vascular Disease Research

Volumn 4, Issue SUPPL. 3, 2007, Pages

  Plutzky, Jorge ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Fenofibrate; Inflammation; Lipid metabolism; Peroxisome proliferator activated receptor alpha

Indexed keywords

FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DRUG TARGETING; DYSLIPIDEMIA; ENERGY BALANCE; HUMAN; INFLAMMATION; LIPID METABOLISM; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION;

EID: 35548942603     PISSN: 14791641     EISSN: None     Source Type: Journal    
DOI: 10.3132/dvdr.2007.052     Document Type: Conference Paper

References (7)

1. Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 2007;115: 518-33.
2. Plutzky J. PPARs as therapeutic targets: reverse cardiology? Science 2003;302:406-07.
3. Marx N, Sukhova GK, Collins T et al. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 1999;22:3125-31.
4. Ziouzenkova O, Perrey S, Asatryan L et al. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an anti-inflammatory role for lipoprotein lipase. Proc Natl Acad Sci USA 2003;100:2730-5.
5. Marx N, Kehrle B, Kohlhammer K et al. PPAR activators as anti-inflammatory mediators in human T lymphocytes. Implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res 2002; 90:703-10.
6. Feldstein AE, Werneburg NW, Canbay A et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-94.
7. Han CY, Chiba T, Campbell JS et al. Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol 2006;26:1806-13.