Hidradenitis suppurativa (acne inversa): Management of a recalcitrant disease

Pediatric Dermatology

Volumn 24, Issue 5, 2007, Pages 465-473

  Lam, Joseph ^a   Krakowski, Andrew C ^a   Friedlander, Sheila F ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; AMINOLEVULINIC ACID; AMINOTRANSFERASE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BOTULINUM TOXIN A; CLINDAMYCIN; CORTICOSTEROID; CYCLOSPORIN; CYPROTERONE ACETATE; DAPSONE; DIANE; DOXYCYCLINE; ERYTHROMYCIN; ETANERCEPT; ETRETIN; ETRETINATE; FINASTERIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; ISOTRETINOIN; METHOTREXATE; MINOCYCLINE; ORAL CONTRACEPTIVE AGENT; PLACEBO; RETINOID; RIFAMPICIN; TETRACYCLINE;

ACNE; AMINOTRANSFERASE BLOOD LEVEL; ANTIBIOTIC RESISTANCE; ANUS; APPLICATION SITE REACTION; AXILLA; BLOOD DYSCRASIA; BODY FLUID; BONE MARROW SUPPRESSION; BRAIN PSEUDOTUMOR; BREAST; CARBON DIOXIDE LASER; CLINICAL FEATURE; CLINICAL TRIAL; CLOTHING; CONSERVATIVE TREATMENT; CROHN DISEASE; CRYOTHERAPY; DEMYELINATING DISEASE; DIARRHEA; DRUG FEVER; DRUG WITHDRAWAL; DYSPEPSIA; EJACULATION; ERECTILE DYSFUNCTION; ERYTHEMA MULTIFORME; EVIDENCE BASED MEDICINE; FLUID RETENTION; FLUSHING; GENITAL SYSTEM; GINGIVA HYPERPLASIA; GYNECOMASTIA; HAIR FOLLICLE; HEMOLYTIC ANEMIA; HEPATITIS; HIRSUTISM; HISTOPATHOLOGY; HORMONAL THERAPY; HUMAN; HYPERTENSION; HYPERTRICHOSIS; HYPERTRIGLYCERIDEMIA; HYPOMAGNESEMIA; HYPOTENSION; IMMUNE DEFICIENCY; INGUINAL CANAL; INJECTION SITE PAIN; INTERSTITIAL PNEUMONIA; KIDNEY DISEASE; LIBIDO DISORDER; LIVER TOXICITY; LOW DRUG DOSE; LUPUS LIKE SYNDROME; LYMPHOMA; MENTAL INSTABILITY; METHEMOGLOBINEMIA; MULTIPLE CYCLE TREATMENT; MYALGIA; NAUSEA; NEPHROTOXICITY; PAIN; PANCREATITIS; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; REVIEW; RIGOR; SERUM SICKNESS; SIDE EFFECT; SKIN IRRITATION; SMOKING CESSATION; SQUAMOUS CELL CARCINOMA; SUPPURATIVE HIDRADENITIS; TACHYCARDIA; TERATOGENICITY; TUBERCULOSIS; UNSPECIFIED SIDE EFFECT; VAGINA CANDIDIASIS; VEIN THROMBOSIS; VOMITING; WEIGHT REDUCTION; XEROSIS;

ANTI-BACTERIAL AGENTS; HIDRADENITIS SUPPURATIVA; HUMANS; IMMUNOSUPPRESSIVE AGENTS; RECURRENCE; RETINOIDS;

EID: 35448982325     PISSN: 07368046     EISSN: 15251470     Source Type: Journal    
DOI: 10.1111/j.1525-1470.2007.00544.x     Document Type: Review

References (80)

1. Jemec GB, Heidenheim M, Nielsen NH. The prevalence of hidradenitis suppuritiva and its potential precursor lesions. J Am Acad Dermatol 1996 35 : 191 194.
2. Jemec GB, Hansen U. Histology of hidradenitis suppurativa. J Am Acad Dermatol 1996 34 : 994 999.
3. Yu CC, Cook MG. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 1990 122 : 763 769.
4. Sellheyer K, Krahl D. "Hidradenitis suppurativa" is acne inversa! An appeal to (finally) abandon a misnomer. Int J Dermatol 2005 44 : 535 540.
5. Jansen I, Altmeyer P, Piewig G. Acne inversa (alias hidradenitis suppurativa). J Eur Acad Dermatol Venereol 2001 15 : 532 540.
6. Goischke HK, Ochsendorf FR. Acne inversa in Crohn's disease. Z Gastroenterol 2001 39 : 965 969.
7. Ostlere LS, Langtry JA, Mortimer PS et al. Hidradenitis suppurativa in Crohn's disease. Br J Dermatol 1991 125 : 384 386.
8. Bedlow AJ, Mortimer PS. Dowling-Degos disease associated with hidradenitis suppurativa. Clin Exp Dermatol 1996 21 : 305 306.
9. Loo WJ, Rytina E, Todd PM. Hidradenitis suppurativa, Dowling-Degos and multiple epidermal cysts: a new follicular occlusion triad. Clin Exp Dermatol 2004 29 : 622 624.
10. Dixit R, George R, Jacob M et al. Dowling-Degos disease, hidradenitis suppurativa and arthritis in mother and daughter. Clin Exp Dermatol 2006 31 : 454 456.
11. Leybishkis B, Fasseas P, Ryan KF et al. Hidradenitis suppurativa and acne conglobata associated with spondyloarthropathy. Am J Med Sci 2001 321 : 195 197.
12. Thein M, Hogarth MB, Acland K. Seronegative arthritis associated with the follicular occlusion triad. Clin Exp Dermatol 2004 29 : 550 552.
13. Gao M, Wang PG, Cui Y et al. Inversa acne (hidradenitis suppurativa): a case report and identification of the locus at chromosome 1p21.1-1q25.3. J Invest Dermatol 2006 126 : 1302 1306.
14. Von Der Werth JM, Williams HC, Raeburn JA. The clinical genetics of hidradenitis suppurativa revisited. Br J Dermatol 2000 142 : 947 953.
15. Fitzsimmons JS, Guilbert PR, Fitzsimmons EM. Evidence of genetic factors in hidradenitis suppurativa. Br J Dermatol 1985 113 : 1 8.
16. Ebling FJ. Hidradenitis suppurativa: an androgen-dependent disorder. Br J Dermatol 1986 115 : 259 262.
17. Palmer RA, Keefe M. Early-onset hidradenitis suppurativa. Clin Exp Dermatol 2001 26 : 501 503.
18. Harrison BJ, Read GF, Hughes LE. Endocrine basis for the clinical presentation of hidradenitis suppurativa. Br J Surg 1988 75 : 972 975.
19. Wiseman MC. Hidradenitis suppurativa: a review. Dermatol Ther 2004 17 : 50 54.
20. Konig A, Lehmann C, Rompel R et al. Cigarette smoking as a triggering factor of hidradenitis suppurativa. Dermatology 1999 198 : 261 264.
21. Short KA, Kalu G, Mortimer PS et al. Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa. Clin Exp Dermatol 2005 30 : 481 483.
22. Rosenzweig LB, Brett AS, Lefaivre JF et al. Hidradenitis suppurativa complicated by squamous cell carcinoma and paraneoplastic neuropathy. Am J Med Sci 2005 329 : 150 152.
23. Altunay IK, Gokdemir G, Kurt A et al. Hidradenitis suppurativa and squamous cell carcinoma. Dermatol Surg 2002 28 : 88 90.
24. Clemmensen OJ. Topical treatment of hidradenitis suppurativa with clindamycin. Int J Dermatol 1983 22 : 325 328.
25. Jemec GB, Wendelboe P. Topical clindamycin versus systemic tetracycline in the treatment of hidradenitis suppurativa. J Am Acad Dermatol 1998 39 : 971 974.
26. Mendonca CO, Griffiths CE. Clindamycin and rifampicin combination therapy for hidradenitis suppurativa. Br J Dermatol 2006 154 : 977 978.
27. Mortimer PS, Dawber RP, Gales MA et al. A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa. Br J Dermatol 1986 115 : 263 268.
28. Sawers RS, Randall VA, Ebling FJ. Control of hidradenitis suppurativa in women using combined antiandrogen (cyproterone acetate) and oestrogen therapy. Br J Dermatol 1986 115 : 269 274.
29. Levesque H, Trivalle C, Manchon ND et al. Fulminant hepatitis due to cyproterone acetate. Lancet 1989 1 : 215 221.
30. Murphy BJ, Collins BJ. Severe hepatitis and liver failure induced by cyproterone acetate. Aust N Z J Med 1996 26 : 724.
31. Kacar S, Akdogan M, Kosar Y et al. Estrogen and cyproterone acetate combination-induced autoimmune hepatitis. J Clin Gastroenterol 2002 35 : 98 100.
32. Eibs HG, Spielmann H, Hagele M. Teratogenic effects of cyproterone acetate and medroxyprogesterone treatment during the pre- and postimplantation period of mouse embryos. I. Teratology 1982 25 : 27 36.
33. Eibs HG, Spielmann H, Jacob-Muller U et al. Teratogenic effects of cyproterone acetate and medroxyprogesterone treatment during the pre- and postimplantation period of mouse embryos. II. Cyproterone acetate and medroxyprogesterone acetate treatment before implantation in vivo and in vitro. Teratology 1982 25 : 291 299.
34. Joseph MA, Jayaseelan E, Ganapathi B et al. Hidradenitis suppurativa treated with finasteride. J Dermatolog Treat 2005 16 : 75 78.
35. Farrell AM, Randall VA, Vafaee T et al. Finasteride as a therapy for hidradenitis suppurativa. Br J Dermatol 1999 141 : 1138 1139.
36. Roberts JL, Fiedler V, Imperato-McGinley J et al. Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss. J Am Acad Dermatol 1999 41 : 555 563.
37. Dicken CH, Powell ST, Spear KL. Evaluation of isotretinoin treatment of hidradenitis suppurativa. J Am Acad Dermatol 1984 11 : 500 502.
38. Brown CF, Gallup DG, Brown VM. Hidradenitis suppurativa of the anogenital region: response to isotretinoin. Am J Obstet Gynecol 1988 158 : 12 15.
39. Boer J, van Gemert MJ. Long-term results of isotretinoin in the treatment of 68 patients with hidradenitis suppurativa. J Am Acad Dermatol 1999 40 : 73 76.
40. Scheman AJ. Nodulocystic acne and hidradenitis suppurativa treated with acitretin: a case report. Cutis 2002 69 : 287 288.
41. Hogan DJ, Light MJ. Successful treatment of hidradenitis suppurativa with acitretin. J Am Acad Dermatol 1988 19 (2 Pt 1 355 356.
42. Chow ET, Mortimer PS. Successful treatment of hidradenitis suppurativa and retroauricular acne with etretinate. Br J Dermatol 1992 126 : 415.
43. Hofer T, Itin PH. Acne inversa: a dapsone-sensitive dermatosis. Hautarzt 2001 52 (10 Pt 2 989 992.
44. Kaur MR, Lewis HM. Hidradenitis suppurativa treated with dapsone: A case series of five patients. J Dermatolog Treat 2006 17 : 211 213.
45. Rose RF, Goodfield MJ, Clark SM. Treatment of recalcitrant hidradenitis suppurativa with oral ciclosporin. Clin Exp Dermatol 2006 31 : 154 155.
46. Buckley DA, Rogers S. Cyclosporin-responsive hidradenitis suppurativa. J R Soc Med 1995 88 : 289P 290P.
47. Gupta AK, Ellis CN, Nickoloff BJ et al. Oral cyclosporine in the treatment of inflammatory and noninflammatory dermatoses. A clinical and immunopathologic analysis. Arch Dermatol 1990 126 : 339 350.
48. Martinez F, Nos P, Benlloch S et al. Hidradenitis suppurativa and Crohn's disease: response to treatment with infliximab. Inflamm Bowel Dis 2001 7 : 323 326.
49. Rosi YL, Lowe L, Kang S. Treatment of hidradenitis suppurativa with infliximab in a patient with Crohn's disease. J Dermatolog Treat 2005 16 : 58 61.
50. Adams DR, Gordon KB, Devenyi AG et al. Severe hidradenitis suppurativa treated with infliximab infusion. Arch Dermatol 2003 139 : 1540 1542.
51. Sullivan TP, Welsh E, Kerdel FA et al. Infliximab for hidradenitis suppurativa. Br J Dermatol 2003 149 : 1046 1049.
52. Lebwohl B, Sapadin AN. Infliximab for the treatment of hidradenitis suppurativa. J Am Acad Dermatol 2003 49 (Suppl. 5 S275 S276.
53. Katsanos KH, Christodoulou DK, Tsianos EV. Axillary hidradenitis suppurativa successfully treated with infliximab in a Crohn's disease patient. Am J Gastroenterol 2002 97 : 2155 2156.
54. Scheinfeld N. Treatment of coincident seronegative arthritis and hidradentis supprativa with adalimumab. J Am Acad Dermatol 2006 55 : 163 164.
55. Cusack C, Buckley C. Etanercept: effective in the management of hidradenitis suppurativa. Br J Dermatol 2006 154 : 726 729.
56. Weinberg JM. An overview of infliximab, etanercept, efalizumab, and alefacept as biologic therapy for psoriasis. Clin Ther 2003 25 : 2487 2505.
57. Williams JD, Griffiths CE. Cytokine blocking agents in dermatology. Clin Exp Dermatol 2002 27 : 585 590.
58. Sauder DN, Mamelak AJ. Understanding the new clinical landscape for psoriasis: a comparative review of biologics. J Cutan Med Surg 2004 8 : 205 212.
59. Maalouf E, Faye O, Poli F et al. Fatal epidermoid carcinoma in hidradenitis suppurativa following treatment with infliximab. Ann Dermatol Venereol 2006 133 (5 Pt 1 473 474.
60. Frohlich D, Baaske D, Glatzel M. Radiotherapy of hidradenitis suppurativa - still valid today? Strahlenther Onkol 2000 176 : 286 289.
61. Strauss RM, Pollock B, Stables GI et al. Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa. Br J Dermatol 2005 152 : 803 804.
62. Gold M, Bridges TM, Bradshaw VL et al. ALA-PDT and blue light therapy for hidradenitis suppurativa. J Drugs Dermatol 2004 3 (Suppl. 1 S32 S35.
63. O'Reilly DJ, Pleat JM, Richards AM. Treatment of hidradenitis suppurativa with botulinum toxin A. Plast Reconstr Surg 2005 116 : 1575 1576.
64. Sharon-Guidetti A, Ziv Y, Kummer E et al. Granulocyte-macrophage colony-stimulating factor for perianal hidradenitis suppurativa: report of a case. Dis Colon Rectum 2006 49 : 682 684.
65. Bong JL, Shalders K, Saihan E. Treatment of persistent painful nodules of hidradenitis suppurativa with cryotherapy. Clin Exp Dermatol 2003 28 : 241 244.
66. Jemec GB. Methotrexate is of limited value in the treatment of hidradenitis suppurativa. Clin Exp Dermatol 2002 27 : 528 529.
67. Ritz JP, Runkel N, Haier J et al. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorectal Dis 1998 13 : 164 168.
68. Brown SC, Kazzazi N, Lord PH. Surgical treatment of perineal hidradenitis suppurativa with special reference to recognition of the perianal form. Br J Surg 1986 73 : 978 980.
69. Weyandt G. Surgical management of acne inversa. Hautarzt 2005 56 : 1033 1039.
70. Mandal A, Watson J. Experience with different treatment modules in hidradenitis suppuritiva: a study of 106 cases. Surgeon 2005 3 : 23 26.
71. Tanaka A, Hatoko M, Tada H et al. Experience with surgical treatment of hidradenitis suppurativa. Ann Plast Surg 2001 47 : 636 642.
72. Harrison BJ, Mudge M, Hughes LE. Recurrence after surgical treatment of hidradenitis suppurativa. Br Med J (Clin Res Ed) 1987 21 : 294.
73. Rompel R, Petres J. Long-term results of wide surgical excision in 106 patients with hidradenitis suppurativa. Dermatol Surg 2000 26 : 638 643.
74. Lapins J, Sartorius K, Emtestam L. Scanner-assisted carbon dioxide laser surgery: a retrospective follow-up study of patients with hidradenitis suppurativa. J Am Acad Dermatol 2002 47 : 280 285.
75. Finley EM, Ratz JL. Treatment of hidradenitis suppurativa with carbon dioxide laser excision and second-intention healing. J Am Acad Dermatol 1996 34 : 465 469.
76. 2 laser stripping-secondary intention technique. Br J Dermatol 1994 131 : 551 556.
77. 2-laser. Case report and literature review. Schweiz Rundsch Med Prax 1993 82 : 941 945.
78. Dalrymple JC, Monaghan JM. Treatment of hidradenitis suppurativa with the carbon dioxide laser. Br J Surg 1987 74 : 420.
79. Slade DE, Powell BW, Mortimer PS. Hidradenitis suppurativa: pathogenesis and management. Br J Plast Surg 2003 56 : 451 461.
80. Ebell MH, Siwek J, Weiss BD et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Physician 2004 69 : 548 556.