Rapid and effective CD3 T-cell depletion with a magnetic cell sorting program to produce peripheral blood progenitor cell products for haploidentical transplantation in children and adults

Transfusion

Volumn 47, Issue 11, 2007, Pages 2134-2142

  Dykes, Josefina H ^a   Toporski, Jacek ^b   Juliusson, Gunnar ^b   Békássy, Albert N ^b   Lenhoff, Stig ^b   Lindmark, Anders ^b   Scheding, Stefan ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD34 ANTIGEN; IMMUNOGLOBULIN G; LEUKOCYTE ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; ARTICLE; BLOOD SAMPLING; CELL TRANSPLANTATION; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INCIDENCE; MAGNETIC SEPARATION; PERIPHERAL BLOOD STEM CELL; STATISTICAL SIGNIFICANCE; T CELL DEPLETION;

ADOLESCENT; ADULT; ANTIGENS, CD3; ANTIGENS, CD34; CHILD; CHILD, PRESCHOOL; HAPLOTYPES; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY TESTING; HUMANS; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; LYMPHOCYTE DEPLETION; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 35448978756     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2007.01438.x     Document Type: Article

References (27)

1. Beatty PG, Clift RA, Mickelson EM, Nisperos BB, Flournoy N, Martin PJ, Sanders JE, Stewart P, Buckner CD, Storb R, et al. Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 1985 313 : 765 71.
2. Anasetti C, Amos D, Beatty PG, Appelbaum FR, Bensinger W, Buckner CD, Clift R, Doney K, Martin PJ, Mickelson E, et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukaemia or lymphoma. N Engl J Med 1989 320 : 197 204.
3. Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F, Ruggeri L, Barbabietola G, Aristei C, Latini P, Reisner Y, Martelli MF. Treatment of high-risk acute leukemia with T-cell depleted stem cell donors with one fully mismatched HLA haplotype. N Engl J Med 1998 339 : 1186 93.
4. Handgretinger R, Klingebiel T, Lang P, Schumm M, Neu S, Geiselhart A, Bader P, Schlegel PG, Greil J, Stachel D, Herzog RJ, Niethammer D. Megadose transplantation of purified peripheral blood CD34+ progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant 2001 27 : 777 83.
5. Schumm M, Lang P, Taylor G. Isolation of highly purified autologous and allogeneic peripheral CD34+ cells using the ClinMACS device. J Hematother 1999 8 : 209 18.
6. Lang P, Handgretinger R, Niethammer D, Schlegel PG, Schumm M, Greil J, Bader P, Engel C, Scheel-Walter H, Eyrich M, Klingebiel T. Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood 2003 101 : 1630 1.
7. Lang P, Schumm M, Greil J, Bader P, Klingebiel T, Müller I, Feuchtinger T, Pfeiffer M, Schlegel PG, Niethammer D, Handgretinger R. A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study. Klin Padiatr 2005 217 : 334 8.
8. Ruggeri L, Capanni M, Martelli MF, Velardi A. Cellular therapy; exploiting NK cell alloreactivity in transplantation. Curr Opin Hematol 2001 8 : 355 9.
9. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplantation. Science 2002 295 : 2097 100.
10. Soiffer RJ, Mauch P, Fairclough D, Alyea E, Anderson K, Fisher D, Freedman A, Bartlett-Pandite L, Robertson M, Schlossman R, Gollob J, Marcus K, Murray C, Kuhlman C, Freeman A, Nadler L, Ritz J. CD6+ T cell depleted allogeneic bone marrow transplantation from genotypically HLA nonidentical related donors. Biol Blood Marrow Transplant 1997 3 : 11 7.
11. Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C, Iacucci R, Zei T, Martelli MP, Gambelunghe C, et al. Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 1994 84 : 3948 55.
12. Gordon PR, Leimig T, Mueller I, Babarin-Dorner A, Holladay MA, Houston J, Kerst G, Geiger T, Handgretinger R. A large-scale method for T cell depletion: towards graft engineering of mobilized peripheral blood stem cells. Bone Marrow Transplant 2002 30 : 69 74.
13. Lenhoff S, Dykes J, Lindmark A, Kurkus J. "Short" mobilization of peripheral blood stem cells in adult donors. Bone Marrow Transplant 2003 31 : S65.
14. Arseniev L, Pickered N, Goudeva L, Hertenstein B, Ganser A. Comparative evaluation of commonly used clones and fluorochrome conjugates of monoclonal antibodies for CD34 antigen detection. J Hematother Stem Cell Res 1999 8 : 547 59.
15. Aversa F, Martelli MF. Transplantation of haploidentically mismatched stem cells for the treatment of malignant diseases. Springer Semin Immunopathol 2004 26 : 155 68.
16. Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S, Felicini R, Falcinelli F, Velardi A, Ruggeri L, Aloisi T, Saab JP, Santucci A, Perruccio K, Martelli MP, Mecucci C, Reisner Y, Martelli MF. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukaemia at high risk of relapse. J Clin Oncol 2005 23 : 3447 54.
17. Lang P, Greil J, Bader P, Handgretinger R, Klingebiel T, Schumm M, Schlegel PG, Feuchtinger T, Pfeiffer M, Scheel-Walter H, Führer M, Martin D, Niethammer D. Long-term outcome after haploidentical stem cell transplantation in children. Blood Cells Mol Dis 2004 33 : 281 7.
18. Aversa F, Berneman ZN, Locatelli F, Martelli MF, Reisner Y, Tabilio A, Velardi A, Vuk-Pavlovic S. Fourth International Workshop on Haploidentical Transplants, Naples, Italy, July 8-10, 2004. Blood Cells Mol Dis 2004 33 : 159 75.
19. Spitzer TR. Haploidentical stem cell transplantation: the always present but overlooked donor. Hematol Am Soc Hematol Educ Program 2005 1 : 390 5.
20. Chen X, Hale GA, Barfield R, Benaim E, Leung WH, Knowles J, Horwitz EM, Woodard P, Kasow K, Yusuf U, Behm FG, Hayden RT, Shurtleff SA, Turner V, Srivastava DK, Handgretinger R. Rapid immune reconstitution after reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. Br J Haematol 2006 135 : 524 32.
21. Barfield RC, Otto M, Houston J, Holladay M, Geiger T, Martin J, Leimig T, Gordon P, Chen X, Handgretinger R. A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy 2004 6 : 1 6.
22. Del Fante C, Perotti C, Viarengo G, Bergamaschi P, Tinelli C, Bellotti L, Marchesi A, Parisi C, Salvaneschi L. Immunomagentic cell selection performed for HLA haploidentical transplants with the CliniMACS device: effect of additional platelet removal on CD34+ cell recovery. Stem Cells Dev 2005 14 : 734 9.
23. Rowley SD, Prather K, Bui KT, Appel M, Felt T, Bensinger WI. Collection of peripheral blood progenitor cells with an automated leukapheresis system. Transfusion 1999 39 : 1200 6.
24. Seidel M, Fritsch G, Matthes-Martin S, Lawitschka A, Lion T, Pötschger U, Rosenmayr A, Fischer G, Gadner H, Peters C. In vitro and in vivo T-cell depletion with myeloablative or reduced-intensity conditioning in pediatric hematopoietic stem cell transplantation. Hematologica 2005 90 : 1405 14.
25. Heitger A, Greinix H, Mannhalter C, Mayerl D, Kern H, Eder J, Fink FM, Niederwieser D, Panzer-Grümayer ER. Requirement of residual thymus to restore normal T-cell subsets after human allogeneic bone marrow transplantation. Transplantation 2000 69 : 2366 73.
26. reg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006 108 : 1291 7.
27. Edinger M, Hoffman P, Ermann J. CD4+CD25+ regulatory T-cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003 9 : 1144 50.