Thrombotic preparedness in aging: A translatable construct for thrombophilias?

Journal of Thrombosis and Thrombolysis

Volumn 24, Issue 3, 2007, Pages 323-325

  Becker, Richard C ^a  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT PROTEIN; ANTIPLASMIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9; D DIMER; FIBRINOGEN; PLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR;

AGING; ARTICLE; ATHEROSCLEROSIS; CEREBROVASCULAR ACCIDENT; ENVIRONMENTAL EXPOSURE; ETHNICITY; HEART INFARCTION; HEMOSTASIS; HOMEOSTASIS; HUMAN; PHENOTYPE; PLASMA VISCOSITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBOCYTE ACTIVATION; THROMBOPHILIA; THROMBOSIS;

AGING; ANIMALS; ATHEROSCLEROSIS; FEMALE; HEMOSTASIS; HUMANS; MALE; MICE; THROMBOPHILIA;

EID: 35448971776     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-007-0094-9     Document Type: Article

References (13)

1. Franchini M (2006) Hemostasis and aging. Crit Rev Oncol Hematol 60:144-151
2. Bauer KA, Weiss LM, Sparrow D, Vokonas PS, Rosenberg RD (1987) Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative aging study. J Clin Invest 80:1527-1534
3. Bauer KA, Kass BL, ten Cate H, Bednarek MA, Hawiger JJ, Rosenberg RD (1989) Detection of factor X activation in humans. Blood 74:2007-2015
4. Bauer KA, Kass BL, ten Cate H, Hawiger JJ, Rosenberg RD (1990) Factor IX is activated in vivo by the tissue factor mechanism. Blood 76:731-736
5. Mari D, Mannucci PM, Coppola R, Bottasso B, Bauer KA, Rosenberg RD (1995) Hypercoagulability in centenarians: The paradox of successful aging. Blood 85:3144-3149
6. Bastyr EJ 3rd, Kadrofske MM, Vinik AI (1990) Platelet activity and phosphoinositide turnover increase with advancing age. Am J Med 88:601-606
7. Reilly IA, FitzGerald GA (1986) Eicosenoid biosynthesis and platelet function with advancing age. Thromb Res 41:545-554
8. Tofler GH, Massaro J, Levy D et al (2005) Relation of the prothrombotic state to increasing age (from the Framingham offspring study). Am J Cardiol 96:1280-1283
9. Lutsey PL, Cushman M, Steffen LM et al (2006) Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: The MESA study. J Thromb Haemost 4:2629-2635
10. Rauscher FM, Goldschmidt-Clermont PJ, Davis BH et al (2003) Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 108:457-463
11. Karra R, Vemullapalli S, Dong C et al (2005) Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci USA 102:16789-16794
12. Zhu S, Liu X, Li Y, Goldschmidt-Clermont PJ, Dong C (2007) Aging in the atherosclerosis milieu may accelerate the consumption of bone marrow endothelial progenitor cells. Arterioscler Thromb Vasc Biol 27:113-119
13. Schmidt-Lucke C, Rossig L, Fichtlscherer S et al (2005) Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation 111:2981-2987