Are there predictors of outcome in depressed elderly nursing home residents during treatment with mirtazapine orally disintegrating tablets?

International Journal of Geriatric Psychiatry

Volumn 22, Issue 10, 2007, Pages 999-1003

  Nelson, J Craig ^a,e   Holden, Karen ^a   Roose, Steven ^b   Salzman, Carl ^c   Hollander, Steven B ^d   Betzel, James V ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Organon Pharmaceuticals USA Inc   (United States)

^e NONE   (United States)

Author keywords

Late life depression; Mirtazapine; Nursing home

Indexed keywords

MIRTAZAPINE;

AGE; AGED; ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG WITHDRAWAL; ELDERLY CARE; FEMALE; GERONTOPSYCHIATRY; HAMILTON SCALE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; NURSING HOME; OUTCOME ASSESSMENT; PREDICTION; PSYCHOLOGIC ASSESSMENT; RESIDENTIAL CARE; SCORING SYSTEM; SEX DIFFERENCE; TABLET DISINTEGRATION; TREATMENT DURATION; TREATMENT OUTCOME; UNITED STATES; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DEPRESSIVE DISORDER; FEMALE; HOMES FOR THE AGED; HUMANS; MALE; MIANSERIN; NURSING HOMES; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; TABLETS; TREATMENT OUTCOME;

EID: 35448967057     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.1779     Document Type: Article

References (42)

1. Alexopoulos GS, Abrams RC, Young RC, et al. 1988. Cornell scale for depression in dementia. Biol Psychiatry 23: 271-284.
2. Alexopoulos GS, Kiosses DN, Heo M. 2005. Executive dysfunction and the course of geriatric depression. Biol Psychiatry 58: 204-210.
3. Bondareff W, Alpert M, Friedhoff AJ, et al. 2000. Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. Am J Psychiatry 157: 729-736.
4. Bosworth HB, Hays JC, George LK, Steffens DC. 2002. Psychosocial and clinical predictors of unipolar depression outcome in older adults, Int J Geriatr Psychiatry 17(3): 238-246.
5. Bruce ML, Leaf PJ, Rozal GP, et al. 1994a. Psychiatric status and 9-year mortality data in the New Haven Epidemiologic Catch-merit Area Study. Am J Psychiatry 151(5): 716-721.
6. Bruce ML, Seeman TE, Merrill SS, et al. 1994b. The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. Am J Public Health 84: 1796-1799.
7. Burrows AB, Salzman C, Satlin A, et al. 2002. A randomized placebo-controlled trial of paroxetine in nursing home residents with non-major depression. Depress Anxiety 15: 102-110.
8. Conwell Y. 2004. Suicide. In Late Life Depression, Roose SP, Sackeim HA (eds). Oxford University Press: Oxford; 95-114.
9. Driscoll HC, Basinski J, Mulsant BH, et al. 2005. Late-onset major depression: clinical and treatment-response variability. Int J Geriatr Psychiatry 20: 661-667.
10. Evans M, Hammond M, Wilson K, et al. 1997. Treatment of depression in the elderly: effect of physical illness on response. Int J Geriatr Psychiatry 12: 1189-1194.
11. Flint AJ, Rifat SL. 1997. Effect of demographic and clinical variables on time to antidepressant response in geriatric depression. Depression Anxiety 5: 103-107.
12. Folstein MF, Folstein SE, McHugh PR. 1975. 'Mini-Mental State': a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198.
13. Gildengers AG, Houck PR, Mulsant BH, et al. 2002. Course and rate of antidepressant response in the very old. J Affect Disord 69(1-3): 177-184.
14. Gildengers AG, Houck PR, Mulsant BH, et al. 2005. Trajectories of treatment response in late-life depression. J Clin Psychopharm 25(Suppl 1): S8-S13.
15. Guy W. 1976. ECDEU Assessment Manual for Psychopharmacology, revised National Institutes of Mental Health: Rockville, MD.
16. Hamilton M. 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
17. Iosifescu DV, Nierenberg AA, Alpert JE, et al. 2003. The impact of medical comorbidity on acute treatment of major depressive disorder. Am J Psychiatry 160: 2122-2127.
18. Kalayam MD, Alexopoulos GS. 1999. Prefrontal dysfunction and treatment response in geriatric depression. Arch Gen Psychiatry 56: 713-718.
19. Katon W, Russo J, Frank E, et al. 2002. Predictors of nonresponse to treatment in primary care patients with dysthymia. Gen Hosp Psychiatry 24: 20-27.
20. Katz IR, Simpson GM, Curlik SM, et al. 1990. Pharmacologic treatment of major depression for elderly patients in residential care settings. J Clin Psychiatry 51: 41-48.
21. Keitner GI, Ryan CE, Miller IW, et al. 1991. 12-month outcome of patients with major depression and comorbid psychiatric or medical illness (compound depression). Am J Psychiatry 148: 345-350.
22. Krishnan KR, Doraiswamy PM, Clary CM. 2005. Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline. Prog Neuro-Psychopharmacol Biol Psychiatry 25: 347-361.
23. Linn BS, Linn MW, Gurel I. 1968. Cumulative illness rating scale. J Am Geriatr Soc 16: 622-626.
24. Lowe B, Schenkel I, Bair M, Gobel C. 2005. Efficacy, predictors of therapy response, and safety of sertraline in routine clinical practice: prospective, open-label, non-interventional post-marketing surveillance study in 1878 patients. J Affective Dis 87: 271-279.
25. Magai C, Kennedy G, Cohen CI, Gomberg D. 2000. A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease. Am J Geriatr Psychiatry 8: 66-74.
26. Mitchell AJ, Subramaniam H. 2005. Prognosis of depression in old age compared to middle age: a systemic review of comparative studies. Am J Psychiatry 162: 1588-1601.
27. Oslin DW, Streim JE, Katz IR, et al. 2000. Heuristic comparison of sertraline with nortriptyline for the treatment of depression in frail elderly patients. Am J Geriatr Psychiatry 8: 141-149.
28. Oslin DW, Ten Have TR, Streim JE, et al. 2003. Probing the safety of medications in the frail elderly; evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents. J Clin Psychiatry 64: 875-882.
29. Pulska T, Pahkala K, Laippalla P, Kivela SL. 1998. Major depression as a predictor of premature deaths in elderly people in Finland: a community study. Acta Psychiatrica Scand 97(6): 408-411.
30. Roose SP, Miyazaki M. 2005. Pharmacologic treatment of depression in patients with heart disease. Psychosom Med 67(Suppl 1): S54-57.
31. Roose SP, Nelson JC, Salzman C, et al. 2003. Open label study of mirtazapine orally disintegrating tablets in depressed patients in the nursing home. Curr Med Res Opin 19: 737-746.
32. Roose SP, Sackeim HA, Krishnan KRR, et al. 2004. Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial. Am J Psychiatry 161: 11.
33. Rosen J, Mulsant BH, Pollock BG. 2000. Sertraline in the treatment of minor depression nursing home residents: a pilot study. Int J Geriatr Psychiatry 15: 177-180.
34. Rovner BW, Katz IR. 1993. Psychiatric disorders in the nursing home: a selective review of studies related to clinical care. Int J Geriatr Psychiatry 8: 75-87.
35. Rovner BW, German PS, Brant LJ, et al. 1991. Depression and mortality in nursing homes. JAMA 265: 993-996.
36. Salzman C. 1999. Practical considerations for the treatment of depression in elderly and very elderly long-term care patients. J Clin Psychiatry 60(Suppl 20): 30-33.
37. Sheikh JI, Cassidy EL, Doraiswamy PM. 2004. Efficacy, safety, tolerability of sertraline in patients with late-life depression and comorbid medical illness. JAGS 52: 86-92.
38. Small GW, Birkett M, Meyers BS, et al. 1996. Impact of physical illness on quality of life and antidepressant response in geriatric major depression. Fluoxetine Collaborative Study Group. JAGS 44(10): 1220-1225.
39. Streim JE, Oslin DW, Katz IR, et al. 2000. Drug treatment of depression in frail elderly nursing home residents. Am J Geriatr Psychiatry 8: 20.
40. Trappler B, Cohen CI. 1998. Use of SSRIs in 'very old' depressed nursing home residents. Am J Geriatr Psych 6: 83-89.
41. Weintraub D, Streim JE, Datto CJ, et al. 2003. The effect of increasing the dose and duration of sertraline trial in the treatment of depressed nursing home residents. J Geriatr Psychiatry Neurol 16: 109-111.
42. Whooley MA, Browner WS. 1998. Association between depressive symptoms and mortality in older women. Study of Osteoporotic Fractures Research Group. Arch Int Med 158(19): 2129-2135.