Functional modulation of the geminivirus AL2 transcription factor and silencing suppressor by self-interaction

Journal of Virology

Volumn 81, Issue 21, 2007, Pages 11972-11981

  Yang, Xiaojuan ^a   Baliji, Surendranath ^b   Buchmann, R Cody ^a   Wang, Hui ^a   Lindbo, John A ^c   Sunter, Garry ^b   Bisaro, David M ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE; CYSTEINE; PROTEIN AL2; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BEET CURLY TOP VIRUS; BIMOLECULAR FLUORESCENCE COMPLEMENTATION; COMPLEX FORMATION; GEMINIVIRUS; GENE SILENCING; GENETIC CODE; GENETIC PROCEDURES; MOLECULAR INTERACTION; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SUPPRESSOR GENE; TOMATO GOLDEN MOSAIC VIRUS; TRANSCRIPTION INITIATION; ZINC FINGER MOTIF;

ADENOSINE KINASE; ALANINE; ANIMALS; CYTOPLASM; GEMINIVIRIDAE; GENE EXPRESSION REGULATION; GENE SILENCING; INSECTS; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MUTATION; PLASMIDS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL PROTEINS; ZINC FINGERS;

BEET CURLY TOP VIRUS; BEGOMOVIRUS; CURTOVIRUS; GEMINIVIRIDAE; TOMATO GOLDEN MOSAIC VIRUS;

EID: 35448965804     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00617-07     Document Type: Article

References (42)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Siedman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. John Wiley and Sons, New York, NY.
2. Baulcombe, D. C. 2004. RNA silencing in plants. Nature 431:356-363.
3. Bisaro, D. M. 2006. Silencing suppression by geminivirus proteins. Virology 344:158-168.
4. Brough, C. L., W. E. Gardiner, N. Inamdar, X. Y. Zhang, M. Ehrlich, and D. M. Bisaro. 1992. DNA methylation inhibits propagation of tomato golden mosaic virus DNA in transfected protoplasts. Plant Mol. Biol. 18:703-712.
5. Ding, S.-W., H. Li, R. Lu, F. Li, and W.-X. Li. 2004. RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res. 102:109-115.
6. Dong, X., R. van Wezel, J. Stanley, and Y. Hong. 2003. Functional characterization of the nuclear localization signal for a suppressor of posttranscriptional gene silencing. J. Virol. 77:7026-7033.
7. Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
8. Elmer, J. S., L. Brand, G. Sunter, W. E. Gardiner, D. M. Bisaro, and S. G. Rogers. 1988. Genetic analysis of tomato golden mosaic virus. II. The product of the AL1 coding sequence is required for replication. Nucleic Acids Res. 16:7043-7060.
9. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340:245-246.
10. Gallo, M. L., D. H. Jackwood, M. Murphy, H. S. Marsden, and D. S. Parris. 1988. Purification of the HSV-1 65 kilodalton DNA binding protein: properties of the protein and evidence of its association with the viral encoded DNA polymerase. J. Virol. 62:2874-2883.
11. Gladfelter, H. J., P. A. Eagle, E. P. B. Fontes, L. Batts, and L. Hanley-Bowdoin. 1997. Two domains of the AL1 protein mediate geminivirus origin recognition. Virology 239:186-197.
12. Hanley-Bowdoin, L., S. Settlage, and D. Robertson. 2004. Reprogramming plant gene expression: a prerequisite to geminivirus replication. Mol. Plant Pathol. 5:149-156.
13. Hao, L., H. Wang, G. Sunter, and D. M. Bisaro. 2003. Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinase. Plant Cell 15:1034-1048.
14. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinase. Cell 75:805-816.
15. Hartitz, M. D., G. Sunter, and D. M. Bisaro. 1999. The geminivirus transactivator (TrAP) is a single-stranded DNA and zinc-binding phosphoprotein with an acidic activation domain. Virology 263:1-14.
16. Hormuzdi, S. G., and D. M. Bisaro. 1995. Genetic analysis of beet curly top virus: examination of the roles of L2 and L3 genes in viral pathogenesis. Virology 206:1044-1054.
17. Hu, C.-D., Y. Chinenov, and T. K. Kerppola. 2002. Visualization of interactions among bZIP and Rel family proteins using bimolecular fluorescence complementation. Mol. Cell 9:789-798.
18. Johansen, L. K., and J. C. Carrington. 2001. Silencing on the spot: induction and suppression of RNA silencing in the Agrobacterium-mediated transient expression system. Plant Physiol. 126:930-938.
19. Kong, L. J., B. M. Orozco, J. L. Roe, S. Nagar, S. Ou, H. S. Feiler, T. Durfee, A. B. Miller, W. Gruissem, D. Robertson, and L. Hanley-Bowdoin. 2000. A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants. EMBO J. 19:3485-3494.
20. Laufs, J., W. Traut, F. Heyraud, V. Matzeit, S. G. Rogers, J. Schell, and B. Gronenborn. 1995. In vitro cleavage and ligation at the viral origin of replication by the replication protein of tomato yellow leaf curl virus. Proc. Natl. Acad. Sci. USA 92:3879-3883.
21. Moffatt, B. A., Y. Y. Stevens, M. S. Allen, J. D. Snider, L. A. Periera, M. I. Todorova, P. S. Summers, E. A. Weretilnyk, L. Martin-Caffrey, and C. Wagner. 2002. Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Plant Physiol. 128:812-821.
22. Restrepo, M. A., D. D. Freed, and J. C. Carrington. 1990. Nuclear transport of plant potyviral proteins. Plant Cell 2:987-998.
23. Roth, B. M., G. J. Pruss, and V. B. Vance. 2004. Plant viral suppressors of RNA silencing. Virus Res. 102:97-108.
24. Ruiz, M. T., O. Voinnet, and D. C. Baulcombe. 1998. Initiation and maintenance of virus-induced gene silencing. Plant Cell 10:937-946.
25. Seemanpillai, M., I. Dry, J. Randles, and A. Rezaian. 2003. Transcriptional silencing of geminiviral promoter-driven transgenes following homologous virus infection. Mol. Plant-Microbe Interact. 16:429-438.
26. Shen, W., and L. Hanley-Bowdoin. 2006. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases. Plant Physiol. 142:1642- 1655.
27. Shivaprasad, P. V., R. Akbergenov, D. Trinks, R. Rajeswaran, K. Veluthambi, T. Hohn, and M. M. Pooggin. 2005. Promoters, transcripts, and regulatory proteins of Mungbean yellow mosaic geminivirus. J. Virol. 79:8149-8163.
28. Stanley, J., J. Latham, M. S. Pinner, I. Bedford, and P. G. Markham. 1992. Mutational analysis of the monopartite geminivirus beet curly top virus. Virology 191:396-405.
29. Sunter, G., and D. M. Bisaro. 2003. Identification of a minimal sequence required for activation of the tomato golden mosaic virus coat protein promoter in protoplasts. Virology 305:452-462.
30. Sunter, G., and D. M. Bisaro. 1997. Regulation of a geminivirus coat protein promoter by AL2 protein (TrAP): evidence for activation and derepression mechanisms. Virology 232:269-280.
31. Sunter, G., and D. M. Bisaro. 1991. Transactivation in a geminivirus: AL2 gene product is needed for coat protein expression. Virology 180:416-419.
32. Sunter, G., and D. M. Bisaro. 1992. Transactivation of geminivirus AR1 and BR1 gene expression by the viral AL2 gene product occurs at the level of transcription. Plant Cell 4:1321-1331.
33. Sunter, G., J. Sunter, and D. M. Bisaro. 2001. Plants expressing tomato golden mosaic virus AL2 or beet curly top virus L2 transgenes show enhanced susceptibility to infection by DNA and RNA viruses. Virology 285:59-70.
34. Trinks, D., R. Rajeswaran, P. V. Shivaprasad, R. Akbergenov, E. J. Oakeley, K. Veluthambi, T. Hohn, and M. Pooggin. 2005. Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes. J. Virol. 79:2517-2527.
35. Vanitharani, R., P. Chellappan, and C. M. Fauquet. 2005. Geminiviruses and RNA silencing. Trends Plant Sci. 10:144-151.
36. Vanitharani, R., P. Chellappan, J. S. Pita, and C. Fauquet. 2004. Differential roles of AC2 and AC4 of cassava geminiviruses in mediating synergism and suppression of posttranscriptional gene silencing. J. Virol. 78:9487-9498.
37. Van Wezel, R., H. Liu, Z. Wu, J. Stanley, and Y. Hong. 2003. Contribution of the zinc finger to zinc and DNA binding by a suppressor of posttranscriptional gene silencing. J. Virol. 77:696-700.
38. Voinnet, O. 2005. Induction and suppression of RNA silencing: insights from viral infections. Nat. Rev. Genet. 6:206-220.
39. Voinnet, O., Y. M. Pinto, and D. C. Baulcombe. 1999. Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants. Proc. Natl. Acad. Sci. USA 96:14147-14152.
40. Wang, H., K. J. Buckley, X. Yang, R. C. Buchmann, and D. M. Bisaro. 2005. Adenosine kinase inhibition and suppression of RNA silencing by geminivirus AL2 and L2 proteins. J. Virol. 79:7410-7418.
41. Wang, H., L. Hao, C.-Y. Shung, G. Sunter, and D. M. Bisaro. 2003. Adenosine kinase is inactivated by geminivirus AL2 and L2 proteins. Plant Cell 15:3020-3032.
42. Xiang, C., P. Han, I. Lutziger, K. Wang, and D. J. Oliver. 1999. A mini binary vector series for plant transformation. Plant Mol. Biol. 40:711-717.