Lef1 regulates COX-2 transcription in chondrocytes

Biochemical and Biophysical Research Communications

Volumn 364, Issue 2, 2007, Pages 270-275

  Yun, Kangsun ^a   Im, Sin Hyeog ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Catenin; Chondrocytes; COX 2; Interleukin 1 ; Lef1; Transcription

Indexed keywords

BETA CATENIN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; LYMPHOID ENHANCER FACTOR 1; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOINFORMATICS; CARTILAGE CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENOMICS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; BETA CATENIN; BINDING SITES; CELLS, CULTURED; CHONDROCYTES; COMPUTATIONAL BIOLOGY; CYCLOOXYGENASE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; IMMUNOPRECIPITATION; LYMPHOID ENHANCER-BINDING FACTOR 1; MICE; MICE, INBRED ICR; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 35448960400     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.129     Document Type: Article

References (19)

1. Park J.Y., Pillinger M.H., and Abramson S.B. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin. Immunol. 119 (2006) 229-240
2. Martel-Pelletier J., Pelletier J.P., and Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin. Arthritis Rheum. 33 (2003) 155-167
3. Largo R., Alvarez-Soria M.A., Diez-Ortego I., Calvo E., Sanchez-Pernaute O., Egido J., and Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 11 (2003) 290-298
4. Kim S.J., Im D.S., Kim S.H., Ryu J.H., Hwang S.G., Seong J.K., Chun C.H., and Chun J.S. Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes. Biochem. Biophys. Res. Commun. 296 (2002) 221-226
5. Eastman Q., and Grosschedl R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell Biol. 11 (1999) 233-240
6. Love J.J., Li X., Case D.A., Giese K., Grosschedl R., and Wright P.E. Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature 376 (1995) 791-795
7. Giese K., Cox J., and Grosschedl R. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 69 (1992) 185-195
8. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., and Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382 (1996) 638-642
9. Willert K., and Jones K.A. Wnt signaling: is the party in the nucleus?. Genes Dev. 20 (2006) 1394-1404
10. Yun K., Choi Y.D., Nam J.H., Park Z., and Im S.H. NF-kappaB regulates Lef1 gene expression in chondrocytes. Biochem. Biophys. Res. Commun. 357 (2007) 589-595
11. Kamionka A., Bogdanska-Urbaniak J., Scholz O., and Hillen W. Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res. 32 (2004) 842-847
12. Bert A.G., Burrows J., Osborne C.S., and Cockerill P.N. Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication. Plasmid 44 (2000) 173-182
13. Dubchak I., Brudno M., Loots G.G., Pachter L., Mayor C., Rubin E.M., and Frazer K.A. Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res. 10 (2000) 1304-1306
14. Mayor C., Brudno M., Schwartz J.R., Poliakov A., Rubin E.M., Frazer K.A., Pachter L.S., and Dubchak I. VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16 (2000) 1046-1047
15. Im S.H., Hueber A., Monticelli S., Kang K.H., and Rao A. Chromatin-level regulation of the IL10 gene in T cells. J. Biol. Chem. 279 (2004) 46818-46825
16. Araki Y., Okamura S., Hussain S.P., Nagashima M., He P., Shiseki M., Miura K., and Harris C.C. Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Res. 63 (2003) 728-734
17. Daniels D.L., and Weis W.I. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. 12 (2005) 364-371
18. Adams M.D. Conserved sequences and the evolution of gene regulatory signals. Curr. Opin. Genet. Dev. 15 (2005) 628-633
19. Palmer M.B., Majumder P., Green M.R., Wade P.A., and Boss J.M. A 3′ enhancer controls snail expression in melanoma cells. Cancer Res. 67 (2007) 6113-6120