The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila females

FEBS Journal

Volumn 274, Issue 21, 2007, Pages 5659-5668

  Domanitskaya, Elena V ^a   Liu, Huanfa ^a   Chen, Shanjun ^a   Kubli, Eric ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Gene expression; Postmating responses; Proteome; Reproduction; Seminal fluid

Indexed keywords

DROSOCIN; HYDROXYPROLINE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN DERIVATIVE; PROTEOME; SEX PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL WALL; DNA MICROARRAY; DROSOPHILA MELANOGASTER; EPITHELIUM; FAT BODY; FEMALE; FEMALE GENITAL SYSTEM; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HEMOLYMPH; IMMUNE RESPONSE; IMMUNE SYSTEM; INNATE IMMUNITY; MALE; MATING; NONHUMAN; OVIDUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REPRODUCTION; RNA ISOLATION; SEMINAL PLASMA; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GLYCOPEPTIDES; HYDROXYPROLINE; IMMUNITY, NATURAL; MALE; MOLECULAR SEQUENCE DATA; OVIDUCTS; PEPTIDES; SEXUAL BEHAVIOR, ANIMAL; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); DROSOPHILA MELANOGASTER; HEXAPODA;

EID: 35448953619     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.06088.x     Document Type: Article

References (36)

1. Wolfner MF, Applebaum S Heifetz Y (2005) Insect gonadal glands and their gene products. In Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology (Gilbert L, Iatrou K Gill S, eds), pp. 179 212. Elsevier, Amsterdam.
2. Kubli E (2003) Sex-peptides: seminal peptides of the Drosophila male. Cell Mol Life Sci 60, 1689 1704.
3. Soller M, Bownes M Kubli E (1997) Mating and sex peptide stimulate the accumulation of yolk in oocytes of Drosophila melanogaster. Eur J Biochem 243, 732 738.
4. Aigaki T, Fleischmann I, Chen PS Kubli E (1991) Ectopic expression of sex peptide alters reproductive behavior of female D. melanogaster. Neuron 7, 557 563.
5. Carvalho GB, Kapahi P, Anderson DJ Benzer S (2006) Allocrine modulation of feeding behavior by the sex peptide of Drosophila. Curr Biol 16, 692 696.
6. Peng J, Zipperlen P Kubli E (2005) Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Curr Biol 15, 1690 1694.
7. Wigby S Chapman T (2005) Sex peptide causes mating costs in female Drosophila melanogaster. Curr Biol 15, 316 321.
8. Ding Z, Haussmann I, Ottiger M Kubli E (2003) Sex-peptides bind to two molecularly different targets in Drosophila melanogaster females. J Neurobiol 55, 372 384.
9. Ottiger M, Soller M, Stocker RF Kubli E (2000) Binding sites of Drosophila melanogaster sex peptide pheromones. J Neurobio. 44, 57 71.
10. Peng J, Chen S, Busser S, Liu H, Honegger T Kubli E (2005) Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila. Curr Biol 15, 207 213.
11. Moshitzky P, Fleischmann I, Chaimov N, Saudan P, Klauser S, Kubli E Applebaum SW (1996) Sex-peptide activates juvenile hormone biosynthesis in the Drosophila melanogaster corpus allatum. Arch Insect Biochem Physio. 32, 363 374.
12. Soller M, Haussmann IU, Hollmann M, Choffat Y, White K, Kubli E Schafer MA (2006) Sex-peptide-regulated female sexual behavior requires a subset of ascending ventral nerve cord neurons. Curr Biol 16, 1771 1782.
13. Fleischmann I, Cotton B, Choffat Y, Spengler M Kubli E (2001) Mushroom bodies and post-mating behaviors of Drosophila melanogaster females. J Neurogenet 15, 117 144.
14. Kvitsiani D Dickson BJ (2006) Shared neural circuitry for female and male sexual behaviours in Drosophila. Curr Biol 16, R355 R356.
15. Domanitskaya EV (2005) Search for the Receptor and Target Genes of Sex-Peptide. Universität Zürich, Zürich.
16. Liu H Kubli E (2003) Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci USA 100, 9929 9933.
17. Klowden ML (2002) Physiological Systems in Insects. Academic Press, San Diego, CA.
18. Nijhout HF (1994) Insect Hormones. Princeton University Press, Princeton, NJ.
19. Schmidt T, Choffat Y, Klauser S Kubli E (1993) The Drosophila melanogaster sex-peptide: a molecular analysis of structure-function relationships. J Insect Physiol 39, 361 368.
20. Chen S (2006) Molecular Analysis of Structure-Function Relationships of Sex-peptide and DUP99B in D. melanogaster. Universität Zürich, Zürich.
21. Charlet M, Lagueux M, Reichhart JM, Hoffmann D, Braun A Meister M (1996) Cloning of the gene encoding the antibacterial peptide drosocin involved in Drosophila immunity. Expression studies during the immune response. Eur J Biochem 241, 699 706.
22. Hoffmann JA (2003) The immune response of Drosophila. Nature 426, 33 38.
23. Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA Imler JL (2000) Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13, 737 748.
24. Villella A, Peyre JB, Aigaki T Hall JC (2006) Defective transfer of seminal-fluid materials during matings of semi-fertile fruitless mutants in Drosophila. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 192, 1253 1269.
25. McGraw LA, Gibson G, Clark AG Wolfner MF (2004) Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. Curr Biol 14, 1509 1514.
26. Soller M, Bownes M Kubli E (1999) Control of oocyte maturation in sexually mature Drosophila females. Dev Biol 208, 337 351.
27. Mack PD, Kapelnikov A, Heifetz Y Bender M (2006) Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Proc Natl Acad Sci USA 103, 10358 10363.
28. Demerec M (1950) Biology of Drosophila. John Wiley & Sons, New York.
29. Chen Q, Behar KL, Xu T, Fan C Haddad GG (2003) Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance. J Biol Chem 278, 49113 49118.
30. Chen Q, Ma E, Behar KL, Xu T Haddad GG (2002) Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem 277, 3274 3279.
31. Roxstrom-Lindquist K, Terenius O Faye I (2004) Parasite-specific immune response in adult Drosophila melanogaster: a genomic study. EMBO Rep 5, 207 212.
32. Kurtz J Franz K (2003) Innate defence: evidence for memory in invertebrate immunity. Nature 425, 37 38.
33. Sadd BM Schmid-Hempel P (2006) Insect immunity shows specificity in protection upon secondary pathogen exposure. Curr Biol 16, 1206 1210.
34. Marchini D, Marri L, Rosetto M, Manetti AG Dallai R (1997) Presence of antibacterial peptides on the laid egg chorion of the medfly Ceratitis capitata. Biochem Biophys Res Commun 240, 657 663.
35. Swanson WJ, Clark AG, Waldrip-Dail HM, Wolfner MF Aquadro CF (2001) Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila. Proc Natl Acad Sci USA 98, 7375 7379.
36. Altincicek B Vilcinskas A (2006) Metamorphosis and collagen-IV-fragments stimulate innate immune response in the greater wax moth, Galleria mellonella. Dev Comp Immunol 30, 1108 1118.