Aminoglycoside/β-lactam combinations in clinical practice

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 5, 2007, Pages 911-912

  Leibovici, Leonard ^a,c   Paul, Mical ^a,b,c  

^a Department of Medicine E ^*  (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cephalosporins; Gram negative infections; Penicillins; Synergism

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEPHALOSPORIN; MECILLINAM; PENICILLIN G;

ABDOMINAL INFECTION; BACTEREMIA; CLINICAL PRACTICE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DENMARK; DRUG EFFICACY; DRUG POTENTIATION; DRUG RESPONSE; DRUG SAFETY; EDITORIAL; EVIDENCE BASED PRACTICE; FEBRILE NEUTROPENIA; GRAM NEGATIVE INFECTION; HUMAN; MONOTHERAPY; MORTALITY; NEPHROTOXICITY; OUTCOME ASSESSMENT; RESPIRATORY TRACT INFECTION; RISK FACTOR; URINARY TRACT INFECTION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY, COMBINATION; HUMANS;

EID: 35448950996     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm377     Document Type: Editorial

References (7)

1. Paul M, Soares-Weiser K, Leibovici L. β-Lactam monotherapy versus β-lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis. BMJ 2003; 326: 1111-5.
2. Paul M, Benuri-Silbiger I, Soares-Weiser K et al. β-Lactam monotherapy versus β-lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: Systematic review and meta-analysis of randomised trials. BMJ 2004; 328: 668-72.
3. Bliziotis IA, Samonis G, Vardakas KZ et al. Effect of aminoglycoside and β-lactam combination therapy versus β-lactam monotherapy on the emergence of antimicrobial resistance: A meta-analysis of randomized, controlled trials. Clin Infect Dis 2005; 41: 149-58.
4. Freundlich M, Thomsen RW, Pedersen L et al. Aminoglycoside treatment mortality after bacteraemia in patients given appropriate empirical therapy: A Danish hospital-based cohort study. J Antimicrob Chemother 2007; 60: 1115-1123.
5. Safdar N, Handelsman J, Maki DG. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis. Lancet Infect Dis 2004; 4: 519-27.
6. Paul M, Leibovici L. Combination antibiotic therapy for Pseudomonas aeruginosa bacteraemia. Lancet Infect Dis 2005; 5: 192-4.
7. Vidal L, Gafter-Gvili A, Borok S et al. Efficacy and safety of aminoglycoside monotherapy: Systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2007; 60 247-57.