-
1
-
-
0033178247
-
Novel anticancer drug discovery
-
Buolamwini J.K. Novel anticancer drug discovery. Curr. Opin. Chem. Biol. 3 (1999) 500-509
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 500-509
-
-
Buolamwini, J.K.1
-
2
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T., Bornmann W., Pellicena P., Miller W.T., Clarkson B., and Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289 (2000) 1938-1942
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
3
-
-
0033103867
-
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis
-
McTigue M.A., Wickersham J.A., Pinko C., Showalter R.E., Parast C.V., Tempczyk-Russell A., Gehring M.R., Mroczkowski B., Kan C.C., Villafranca J.E., and Appelt K. Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure 7 (1999) 319-330
-
(1999)
Structure
, vol.7
, pp. 319-330
-
-
McTigue, M.A.1
Wickersham, J.A.2
Pinko, C.3
Showalter, R.E.4
Parast, C.V.5
Tempczyk-Russell, A.6
Gehring, M.R.7
Mroczkowski, B.8
Kan, C.C.9
Villafranca, J.E.10
Appelt, K.11
-
4
-
-
0037102153
-
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
-
Biondi R.M., Komander D., Thomas C.C., Lizcano J.M., Deak M., Alessi D.R., and van Aalten D.M.F. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J. 21 (2002) 4219-4228
-
(2002)
EMBO J.
, vol.21
, pp. 4219-4228
-
-
Biondi, R.M.1
Komander, D.2
Thomas, C.C.3
Lizcano, J.M.4
Deak, M.5
Alessi, D.R.6
van Aalten, D.M.F.7
-
5
-
-
0842310394
-
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
-
Griffith J., Black J., Faerman C., Swenson L., Wynn M., Lu F., Lippke J., and Saxena K. The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol. Cell 13 (2004) 169-178
-
(2004)
Mol. Cell
, vol.13
, pp. 169-178
-
-
Griffith, J.1
Black, J.2
Faerman, C.3
Swenson, L.4
Wynn, M.5
Lu, F.6
Lippke, J.7
Saxena, K.8
-
6
-
-
0027276583
-
Purification and crystallization of human cyclin-dependent kinase 2
-
Rosenblatt J., De Bondt H., Jancarik J., Morgan D.O., and Kim S.H. Purification and crystallization of human cyclin-dependent kinase 2. J. Mol. Biol. 230 (1993) 1317-1319
-
(1993)
J. Mol. Biol.
, vol.230
, pp. 1317-1319
-
-
Rosenblatt, J.1
De Bondt, H.2
Jancarik, J.3
Morgan, D.O.4
Kim, S.H.5
-
7
-
-
0034951384
-
STI571: targeting BCR-ABL as therapy for CML
-
Mauro M.J., and Druker B.J. STI571: targeting BCR-ABL as therapy for CML. Oncologist 6 (2001) 230-232
-
(2001)
Oncologist
, vol.6
, pp. 230-232
-
-
Mauro, M.J.1
Druker, B.J.2
-
8
-
-
0036769168
-
Imatinib: a selective tyrosine kinase inhibitor
-
Manley P.W., Cowan-Jacob S.W., Buchdunger E., Fabbro D., Fendrich G., Furet P., Meyer T., and Zimmermann J. Imatinib: a selective tyrosine kinase inhibitor. Eur. J. Cancer 38 Suppl 5 (2002) S19-S27
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Buchdunger, E.3
Fabbro, D.4
Fendrich, G.5
Furet, P.6
Meyer, T.7
Zimmermann, J.8
-
9
-
-
0038386883
-
Amino-acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR-studies
-
Strauss A., Bitsch F., Cutting B., Fendrich G., Graff P., Liebetanz J., Zurini M., and Jahnke W. Amino-acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR-studies. J. Biomol. NMR 26 (2003) 367-372
-
(2003)
J. Biomol. NMR
, vol.26
, pp. 367-372
-
-
Strauss, A.1
Bitsch, F.2
Cutting, B.3
Fendrich, G.4
Graff, P.5
Liebetanz, J.6
Zurini, M.7
Jahnke, W.8
-
10
-
-
0033947625
-
New anilinophtalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinase useful as antagonists of tumor-driven angiogenesis
-
Bold G., Altmann K.H., Frei J., Lang M., Manley P.W., Traxler P., Wietfeld B., Brüggen J., Buchdunger E., Cozens R., Ferrari S., Furet P., Hofmann F., Martiny- Baron G., Mestan J., Rösel J., Sills M., Stover D., Acemoglu F., Boss E., Emmenegger R., Lässer L., Masso E., Roth R., Schlachter C., Vetterli W., Wyss D., and Wood J.M. New anilinophtalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinase useful as antagonists of tumor-driven angiogenesis. J. Med. Chem. 43 (2000) 2310-2323
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2310-2323
-
-
Bold, G.1
Altmann, K.H.2
Frei, J.3
Lang, M.4
Manley, P.W.5
Traxler, P.6
Wietfeld, B.7
Brüggen, J.8
Buchdunger, E.9
Cozens, R.10
Ferrari, S.11
Furet, P.12
Hofmann, F.13
Martiny- Baron, G.14
Mestan, J.15
Rösel, J.16
Sills, M.17
Stover, D.18
Acemoglu, F.19
Boss, E.20
Emmenegger, R.21
Lässer, L.22
Masso, E.23
Roth, R.24
Schlachter, C.25
Vetterli, W.26
Wyss, D.27
Wood, J.M.28
more..
-
11
-
-
0035413601
-
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
-
Newton A.C. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. 101 (2001) 2353-2364
-
(2001)
Chem. Rev.
, vol.101
, pp. 2353-2364
-
-
Newton, A.C.1
-
13
-
-
3042747695
-
Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis
-
Manley P.W., Bold G., Fendrich G., Furet P., Mestan J., Meyer T., Meyhack B., Stark W., Strauss A., and Wood J. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis. Cell. Mol. Biol. Lett. 8 (2003) 532-533
-
(2003)
Cell. Mol. Biol. Lett.
, vol.8
, pp. 532-533
-
-
Manley, P.W.1
Bold, G.2
Fendrich, G.3
Furet, P.4
Mestan, J.5
Meyer, T.6
Meyhack, B.7
Stark, W.8
Strauss, A.9
Wood, J.10
-
14
-
-
12144290647
-
Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis
-
Manley P.W., Bold G., Bruggen J., Fendrich G., Furet P., Mestan J., Schnell C., Stolz B., Meyer T., Meyhack B., Stark W., Strauss A., and Wood J. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis. Biochem. Biophys. Acta 1697 (2004) 17-27
-
(2004)
Biochem. Biophys. Acta
, vol.1697
, pp. 17-27
-
-
Manley, P.W.1
Bold, G.2
Bruggen, J.3
Fendrich, G.4
Furet, P.5
Mestan, J.6
Schnell, C.7
Stolz, B.8
Meyer, T.9
Meyhack, B.10
Stark, W.11
Strauss, A.12
Wood, J.13
-
15
-
-
35448935480
-
-
G. Rummel, W. Stark, A. Strauss, J. Wagner, Three-dimensional structure of the catalytic domain of Protein Kinase C theta, methods and use thereof, Patent WO 2004/076654 A1 (2003).
-
-
-
-
16
-
-
24644483798
-
Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells
-
Strauss A., Bitsch F., Fendrich G., Graff P., Knecht R., Meyhack B., and Jahnke W. Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells. J. Biomol. NMR 31 (2005) 343-349
-
(2005)
J. Biomol. NMR
, vol.31
, pp. 343-349
-
-
Strauss, A.1
Bitsch, F.2
Fendrich, G.3
Graff, P.4
Knecht, R.5
Meyhack, B.6
Jahnke, W.7
-
17
-
-
0036125150
-
CGP 79787D (PTK787/ZK222584), CGP 84738, NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylmethyl)phthalazines as inhibitors of VEGF- and BFGF-induced angiogenesis
-
Bold G., Frei J., Furet P., Manley P.W., Brüggen J., Cozens R., Ferrari S., Hofmann F., Martiny-Baron G., Mestan J., Meyer T., and Wood J.M. CGP 79787D (PTK787/ZK222584), CGP 84738, NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylmethyl)phthalazines as inhibitors of VEGF- and BFGF-induced angiogenesis. Drugs of the Future 27 (2002) 43-55
-
(2002)
Drugs of the Future
, vol.27
, pp. 43-55
-
-
Bold, G.1
Frei, J.2
Furet, P.3
Manley, P.W.4
Brüggen, J.5
Cozens, R.6
Ferrari, S.7
Hofmann, F.8
Martiny-Baron, G.9
Mestan, J.10
Meyer, T.11
Wood, J.M.12
-
18
-
-
17544387877
-
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors
-
Hennequin L.F., Thomas A.P., Johnstone C., Stokes E.S.E., Plé P.A., Lohmann J.-J.M., Ogilvie D.J., Dukes M., Wedge S.R., Curwen J.O., Kendrew J., and Lambert-van der Brempt C. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. 42 (1999) 5369-5389
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5369-5389
-
-
Hennequin, L.F.1
Thomas, A.P.2
Johnstone, C.3
Stokes, E.S.E.4
Plé, P.A.5
Lohmann, J.-J.M.6
Ogilvie, D.J.7
Dukes, M.8
Wedge, S.R.9
Curwen, J.O.10
Kendrew, J.11
Lambert-van der Brempt, C.12
-
19
-
-
0027510002
-
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction
-
Bit R.A., Davis P.D., Elliott L.H., Harris W., Hill C.H., Keech E., Kumar H., Lawton G., Maw A., Nixon J.S., Vesey D.R., Wadsworth J., and Wilkinson S.E. Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. J. Med. Chem. 36 (1993) 21-29
-
(1993)
J. Med. Chem.
, vol.36
, pp. 21-29
-
-
Bit, R.A.1
Davis, P.D.2
Elliott, L.H.3
Harris, W.4
Hill, C.H.5
Keech, E.6
Kumar, H.7
Lawton, G.8
Maw, A.9
Nixon, J.S.10
Vesey, D.R.11
Wadsworth, J.12
Wilkinson, S.E.13
-
20
-
-
0027248964
-
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
-
Wilkinson S.E., Parker P.J., and Nixon J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294 (1993) 335-337
-
(1993)
Biochem. J.
, vol.294
, pp. 335-337
-
-
Wilkinson, S.E.1
Parker, P.J.2
Nixon, J.S.3
-
21
-
-
0026533930
-
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides
-
Davies P.D., Hill C.H., Lawton G., Nixon J.S., Wilkinson S.E., Hurst S.A., Keech E., and Turner S.E. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J. Med. Chem. 35 (1992) 177-184
-
(1992)
J. Med. Chem.
, vol.35
, pp. 177-184
-
-
Davies, P.D.1
Hill, C.H.2
Lawton, G.3
Nixon, J.S.4
Wilkinson, S.E.5
Hurst, S.A.6
Keech, E.7
Turner, S.E.8
-
22
-
-
0027418818
-
Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
-
Baier G., Telford D., Giampa L., Coggeshall K.M., Baier-Bitterlich G., Isakov N., and Altman A. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268 (1993) 4997-5004
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4997-5004
-
-
Baier, G.1
Telford, D.2
Giampa, L.3
Coggeshall, K.M.4
Baier-Bitterlich, G.5
Isakov, N.6
Altman, A.7
-
23
-
-
0003609019
-
-
Oxford University Press, New York, NY
-
O'Reilly D.R., Miller L.K., and Luckow V.A. Baculovirus Expression Vectors (1994), Oxford University Press, New York, NY
-
(1994)
Baculovirus Expression Vectors
-
-
O'Reilly, D.R.1
Miller, L.K.2
Luckow, V.A.3
-
24
-
-
0028884983
-
Secretion of biologically active human proapolipoprotein A-1 in a baculovirus-insect cell system: protection from degradation by protease inhibitors
-
Pyle L.E., Barton P., Fujiwara Y., Mitchell A., and Fidge N. Secretion of biologically active human proapolipoprotein A-1 in a baculovirus-insect cell system: protection from degradation by protease inhibitors. J. Lipid Res. 36 (1995) 2355-2361
-
(1995)
J. Lipid Res.
, vol.36
, pp. 2355-2361
-
-
Pyle, L.E.1
Barton, P.2
Fujiwara, Y.3
Mitchell, A.4
Fidge, N.5
-
25
-
-
0035046538
-
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five™ cells
-
Martenson P.M., and Justesen J. Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five™ cells. BioTechniques 30 (2001) 782-792
-
(2001)
BioTechniques
, vol.30
, pp. 782-792
-
-
Martenson, P.M.1
Justesen, J.2
-
26
-
-
0036427303
-
Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system
-
Ramos L., Kopec L.A., Sweitzer S.M., Fornwald J.A., Zhao H., Mcallister P., McNulty D.E., Trill J.J., and Kane J.F. Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system. Cytotechnology 38 (2002) 37-41
-
(2002)
Cytotechnology
, vol.38
, pp. 37-41
-
-
Ramos, L.1
Kopec, L.A.2
Sweitzer, S.M.3
Fornwald, J.A.4
Zhao, H.5
Mcallister, P.6
McNulty, D.E.7
Trill, J.J.8
Kane, J.F.9
-
27
-
-
5344251036
-
Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells
-
Spenger A., Ernst W., Condreay J.P., Kost T.A., and Grabherr R. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Expr. Purif. 38 (2004) 17-23
-
(2004)
Protein Expr. Purif.
, vol.38
, pp. 17-23
-
-
Spenger, A.1
Ernst, W.2
Condreay, J.P.3
Kost, T.A.4
Grabherr, R.5
-
28
-
-
33846460839
-
Crystallization of protein-ligand complexes
-
Hassell A.M., An G., Bledsoe R.K., Bynum J.N., Carter III H.L., Deng S.J., Gampe R.T., Grisard T.E., Madauss K.P., Nolte R.T., Rocque W.J., Wang L., Weaver K.L., Williams S.P., Wisely G.B., Xu R., and Shewchuk L.M. Crystallization of protein-ligand complexes. Acta Cryst. D63 (2007) 72-79
-
(2007)
Acta Cryst.
, vol.D63
, pp. 72-79
-
-
Hassell, A.M.1
An, G.2
Bledsoe, R.K.3
Bynum, J.N.4
Carter III, H.L.5
Deng, S.J.6
Gampe, R.T.7
Grisard, T.E.8
Madauss, K.P.9
Nolte, R.T.10
Rocque, W.J.11
Wang, L.12
Weaver, K.L.13
Williams, S.P.14
Wisely, G.B.15
Xu, R.16
Shewchuk, L.M.17
-
29
-
-
33750470057
-
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
-
Vedadi M., Nielsen F.H., Allali-Hassani A., Fedorov O.Y., Finerty Jr. P.J., Wasney G.A., Yeung R., Arrowsmith C., Ball L.J., Berglund H., Hui R., Marsden B.D., Nordlund P., Sundstrom M., Weigelt J., and Edwards A.M. Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc. Natl. Acad. Sci. USA 103 43 (2006) 15835-15840
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.43
, pp. 15835-15840
-
-
Vedadi, M.1
Nielsen, F.H.2
Allali-Hassani, A.3
Fedorov, O.Y.4
Finerty Jr., P.J.5
Wasney, G.A.6
Yeung, R.7
Arrowsmith, C.8
Ball, L.J.9
Berglund, H.10
Hui, R.11
Marsden, B.D.12
Nordlund, P.13
Sundstrom, M.14
Weigelt, J.15
Edwards, A.M.16
-
30
-
-
33751272653
-
Structural biology of protein tyrosine kinases
-
Cowan-Jacob S.W. Structural biology of protein tyrosine kinases. Cell. Mol. Life Sci. 63 (2006) 2608-2625
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 2608-2625
-
-
Cowan-Jacob, S.W.1
|