Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells

Biochemical and Biophysical Research Communications

Volumn 364, Issue 2, 2007, Pages 313-317

  Abdelmohsen, Kotb ^a   Sauerbier, Elisabeth ^a   Ale Agha, Niloofar ^a   Beier, Juliane ^a   Walter, Philippe ^a   Galban, Stefanie ^a   Stuhlmann, Dominik ^a   Sies, Helmut ^a   Klotz, Lars Oliver ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Connexin 43; Epidermal growth factor; ERK 1 2; ERK 5; Gap junction; Menadione

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CONNEXIN 43; EPIDERMAL GROWTH FACTOR; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; PROTEIN INHIBITOR;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EPITHELIUM CELL; GAP JUNCTION; LIVER CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL COMMUNICATION; CELL LINE; CONNEXIN 43; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; GAP JUNCTIONS; LIVER; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 7; PHOSPHORYLATION; RATS; RECOMBINANT PROTEINS; VITAMIN K 3;

RATTUS;

EID: 35448942725     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.132     Document Type: Article

References (27)

1. Simon A.M., and Goodenough D.A. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 8 (1998) 477-483
2. Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., and Söhl G. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383 (2002) 725-737
3. Lampe P.D., and Lau A.F. The effects of connexin phosphorylation on gap junctional communication. Int. J. Biochem. Cell Biol. 36 (2004) 1171-1186
4. Hossain M.Z., Ao P., and Boynton A.L. Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen-activated protein kinase. J. Cell Physiol. 176 (1998) 332-341
5. Hossain M.Z., Jagdale A.B., Ao P., Kazlauskas A., and Boynton A.L. Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. J. Biol. Chem. 274 (1999) 10489-10496
6. Lau A.F., Kanemitsu M.Y., Kurata W.E., Danesh S., and Boynton A.L. Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. Mol. Biol. Cell 3 (1992) 865-874
7. Kanemitsu M.Y., and Lau A.F. Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. Mol. Biol. Cell 4 (1993) 837-848
8. Warn-Cramer B.J., Lampe P.D., Kurata W.E., Kanemitsu M.Y., Loo L.W., Eckhart W., and Lau A.F. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J. Biol. Chem. 271 (1996) 3779-3786
9. Lee J.D., Ulevitch R.J., and Han J. Primary structure of BMK1: a new mammalian map kinase. Biochem. Biophys. Res. Commun. 213 (1995) 715-724
10. Zhou G., Bao Z.Q., and Dixon J.E. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270 (1995) 12665-12669
11. Mody N., Campbell D.G., Morrice N., Peggie M., and Cohen P. An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. Biochem. J. 372 (2003) 567-575
12. Kato Y., Tapping R.I., Huang S., Watson M.H., Ulevitch R.J., and Lee J.D. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395 (1998) 713-716
13. Kamakura S., Moriguchi T., and Nishida E. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases: identification and characterization of a signaling pathway to the nucleus. J. Biol. Chem. 274 (1999) 26563-26571
14. Abe J., Kusuhara M., Ulevitch R.J., Berk B.C., and Lee J.D. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J. Biol. Chem. 271 (1996) 16586-16590
15. Cameron S.J., Malik S., Akaike M., Lerner-Marmarosh N., Yan C., Lee J.D., Abe J., and Yang J. Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. J. Biol. Chem. 278 (2003) 18682-18688
16. Mody N., Leitch J., Armstrong C., Dixon J., and Cohen P. Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett. 502 (2001) 21-24
17. Tsao M.S., Smith J.D., Nelson K.G., and Grisham J.W. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp. Cell Res. 154 (1984) 38-52
18. Coleman W.B., McCullough K.D., Esch G.L., Faris R.A., Hixson D.C., Smith G.J., and Grisham J.W. Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver. Am. J. Pathol. 151 (1997) 353-359
19. Abdelmohsen K., Patak P., von Montfort C., Melchheier I., Sies H., and Klotz L.O. Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation. Methods Enzymol. 378 (2004) 258-272
20. Klotz L.O., Patak P., Ale-Agha N., Buchczyk D.P., Abdelmohsen K., Gerber P.A., von Montfort C., and Sies H. 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. Cancer Res. 62 (2002) 4922-4928
21. Abdelmohsen K., Gerber P.A., von Montfort C., Sies H., and Klotz L.O. Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. J. Biol. Chem. 278 (2003) 38360-38367
22. Sebolt-Leopold J.S., Dudley D.T., Herrera R., Van B.K., Wiland A., Gowan R.C., Tecle H., Barrett S.D., Bridges A., Przybranowski S., Leopold W.R., and Saltiel A.R. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med. 5 (1999) 810-816
23. Squires M.S., Nixon P.M., and Cook S.J. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem. J. 366 (2002) 673-680
24. Warn-Cramer B.J., Cottrell G.T., Burt J.M., and Lau A.F. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J. Biol. Chem. 273 (1998) 9188-9196
25. Lin R., Warn-Cramer B.J., Kurata W.E., and Lau A.F. v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication. J. Cell Biol. 154 (2001) 815-827
26. Sarkozi R., Miller B., Pollack V., Feifel E., Mayer G., Sorokin A., and Schramek H. ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. J. Cell Physiol. 211 (2007) 88-100
27. Abdelmohsen K., von Montfort C., Stuhlmann D., Gerber P.A., Decking U.K., Sies H., and Klotz L.O. Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells. Biol. Chem. 386 (2005) 217-223