Adipose tissue and liver lipid metabolism in obese children: Role of the body mass index and the presence of acanthosis nigricans

Diabetic Medicine

Volumn 24, Issue 11, 2007, Pages 1192-1198

  Bonet, B ^a,b   Viana, M ^b   Sanchez Vera I ^b   Quintanar, A ^a   Martinez J ^a   Espino, M ^a  

^a HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Children; Insulin; Obesity; Triglycerides

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADIPONECTIN; FATTY ACID; GLUCOSE; GLYCEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ACANTHOSIS NIGRICANS; ADIPOSE TISSUE; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; OBESITY; PEDIATRIC HOSPITAL; PROTEIN BLOOD LEVEL; PUBERTY; SCHOOL CHILD; SEX RATIO; STATISTICAL ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ACANTHOSIS NIGRICANS; ADIPOSE TISSUE; BODY MASS INDEX; CHILD; FEMALE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MALE; OBESITY; PREDICTIVE VALUE OF TESTS; TRIGLYCERIDES;

EID: 35448935696     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02230.x     Document Type: Article

References (30)

1. Williams CL, Hayman LL, Daniles SR, Robinson TN, Steinberger J, Paridon S et al. Cardiovascular health in childhood. A statement for health professionals from the committee on atherosclerosis, hypertension and obesity in the young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2002 106 : 143 160.
2. Ogden CL, Carroll LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. J Am Med Assoc 2006 295 : 1549 1555.
3. Young TK, Dean HJ, Flett B, Wood-Steiman P. Childhood obesity in a population at high risk for type 2 diabetes. J Pediatr 2000 136 : 365 369.
4. Sinha R, Fisch G, Teague B, Tamborlane WV, Banya B, Allen K et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002 346 : 802 810.
5. Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996 128 : 608 615.
6. Coppack SW, Jensen MD, Miles JM. In vivo regulation of lipolysis in humans. J Lipid Res 1994 35 : 177 193.
7. Smith U. Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerances - is insulin resistance initiated in the adipose tissue? Int J Obes Relat Metab Disord 2002 26 : 897 904.
8. Eckel RH, Grundy SM, Zimmert PZ. The metabolic syndrome. Lancet 2005 365 : 1415 1428.
9. Reinehr T, Kiess W, Andler W. Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids. Metabolism 2005 54 : 397 402.
10. Arner P, Bolinder J, Engfeldt P, Ostman J. The anti-lipolitic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation. Metabolism 1981 30 : 753 760.
11. Howard BV, Savage PJ, Nagulesparan M, Bennion LJ, Unger RH, Bennett PH. Evidence for marked sensitivity to the anti-lipolytic action of insulin in obese maturity-onset diabetics. Metabolism 1979 28 : 744 750.
12. McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 1980 49 : 395 420.
13. Kershaw EE, Flier JS. Adipose tissue as an endrocrine organ. J Clin Endocrinol Metab 2004 89 : 2548 2556.
14. Kanh BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000 106 : 473 481.
15. Howard BV. Insulin resistance and lipid metabolism. Am J Cardiol 1999 84 : 28J 32J.
16. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and Type 2 diabetes. Endocr Rev 2002 23 : 201 229.
17. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and non-alcoholic fatty liver diseases in mice. J Clin Invest 2003 112 : 91 100.
18. Ten S, Maclaren N. Insulin resistance syndrome in children. J Clin Endocrinol Metab 2004 89 : 2526 2539.
19. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999 116 : 1413 1419.
20. Angulo P. Non-alcoholic fatty liver disease. N Engl J Med 2002 346 : 1221 1231.
21. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children. Circulation 2003 107 : 1448 1453.
22. Nguyen TT, Keil MF, Russell DL, Pathomvanich A, Uwaifo GI, Sebring NG et al. Relation of acanthosis nigricans to hyperinsulinemia and insulin senstitivity in overweight African American and white children. J Pediatr 2001 138 : 474 480.
23. Kobaissi HA, Weigensberg MJ, Ball GDC, Cruz ML, Shaibi GQ, Goran MI. Relation between Acanthosis Nigricans and insulin sensitivity in overweight Hispanic children at risk for type 2 diabetes. Diabetes Care 2004 27 : 1412 1416.
24. Hernandez M, Castellet J, Garcia M, Narvaiza JL, Rincon JM, Ruiz I et al. Curvas y tablas de crecimiento. Instituto de Investigación sobre Crecimiento y Desarrollo. In : Fundacion Faustino Orbegozo Eizaguirre. Madrid : 1988 : 117 150.
25. Somogyi M. Determination of blood sugar. J Biol Chem 1945 160 : 69 73.
26. Bonet B, Herrera E. Maternal hypothyroidism during the first half of gestation compromises normal catabolic adaptations of late gestation in the rat. Endocrinology 1991 129 : 210 216.
27. Mattews DR, Hosker JP, Rudensky AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 419.
28. Laws A, Hoen HM, Selby JV, Saad MF, Haffner SM, Howard BV, for the Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Arterioscler Thromb Vasc Biol 1997 17 : 64 71.
29. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E. A high concentration of fasting plasma non-esterified fatty acid is a risk factor for the development of NIDDM. Diabetologia 1995 38 : 1213 1217.
30. Taskinen MR, Bogardus C, Kennedy A, Howard BV. Multiple disturbances of free fatty acid metabolism in non-insulin-dependent diabetes. J Clin Invest 1985 79 : 637 644.