Lead optimization strategies and tactics applied to the discovery of melanin concentrating hormone receptor 1 antagonists

Current Topics in Medicinal Chemistry

Volumn 7, Issue 15, 2007, Pages 1471-1488

  Kym, Philip R ^a   Judd, Andrew S ^a   Lynch, John K ^a   Iyengar, Rajesh ^a   Vasudevan, Anil ^a   Souers, Andrew J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

4 Aminoquinoline; Coumarin; hERG channel; Indazoles; MCHr1 potency; Rat cardiovascular assay

Indexed keywords

1,4 DIAMINOCYCLOHEXYL 4 AMINOQUINOLINE; 2 AMINO 8 ALKOXYQUINOLINE; 2 AMINOQUINOLINE DERIVATIVE; 4 AMINOPIPERIDINE DERIVATIVE; 4 AMINOQUINOLINE DERIVATIVE; 5 AMINOPIPERIDINE DERIVATIVE; AGENTS AFFECTING METABOLISM; AMINOALKYLINDOLE DERIVATIVE; ANILINE; ANTIOBESITY AGENT; BENZAMIDE; BENZIMIDAZOLE; COUMARIN; COUMARIN DERIVATIVE; DEXFENFLURAMINE; DICHLOROBENZIMIDAZOLE; INDAZOLE DERIVATIVE; INDOLE; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; OCTAHYDRONAPHTHYRIDINE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; PYRROLIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; SIBUTRAMINE; TRICYCLIC AMINOPIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CARDIOTOXICITY; CROSS REACTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EXPOSURE; DRUG INDUSTRY; DRUG PENETRATION; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART HEMODYNAMICS; HIGH THROUGHPUT SCREENING; IC 50; IN VIVO STUDY; NONHUMAN; OBESITY; REVIEW; SINGLE DRUG DOSE; WEIGHT REDUCTION;

AMIDES; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; RECEPTORS, PITUITARY HORMONE; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35448932505     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782194699     Document Type: Review

References (22)

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16. For current statistics on the obesity epidemic, see http://win.niddk.nih.gov.
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