Stability engineering, biophysical, and biological characterization of the myeloid activating receptor immunoglobulin-like transcript 1 (ILT1/LIR-7/LILRA2)

Protein Expression and Purification

Volumn 56, Issue 2, 2007, Pages 253-260

  Chen, Yong ^a,b   Chu, Fuliang ^a,b   Gao, Feng ^a,c   Zhou, Bin ^a   Gao, George F ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Activating receptor; Crystallization; Dimer; ILT1; LILRA2; LIR 7; Monomer; Protein engineering

Indexed keywords

BIOTIN; IMMUNOGLOBULIN RECEPTOR; LIGAND; LILRA2 PROTEIN, HUMAN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOLOGICAL MODEL; BIOPHYSICS; CHEMISTRY; DIMERIZATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BIOPHYSICS; BIOTIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS;

EID: 35448930319     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2007.08.010     Document Type: Article

References (33)

1. Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J., Angman L., Cella M., and Lopez-Botet M. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186 (1997) 1809-1818
2. Cosman D., Fanger N., Borges L., Kubin M., Chin W., Peterson L., and Hsu M.L. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7 (1997) 273-282
3. Borges L., Hsu M.L., Fanger N., Kubin M., and Cosman D. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159 (1997) 5192-5196
4. Samaridis J., and Colonna M. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27 (1997) 660-665
5. Colonna M., Nakajima H., and Cella M. A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin. Immunol. 12 (2000) 121-127
6. Dietrich J., Nakajima H., and Colonna M. Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells. Microbes Infect. 2 (2000) 323-329
7. Willcox B.E., Thomas L.M., and Bjorkman P.J. Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. Nat. Immunol. 4 (2003) 913-919
8. Chapman T.L., Heikeman A.P., and Bjorkman P.J. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11 (1999) 603-613
9. Colonna M., Nakajima H., Navarro F., and Lopez-Botet M. A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J. Leukoc. Biol. 66 (1999) 375-381
10. Willcox B.E., Thomas L.M., Chapman T.L., Heikema A.P., West Jr. A.P., and Bjorkman P.J. Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18. BMC Struct. Biol. 2 (2002) 6-15
11. Chapman T.L., Heikema A.P., West Jr. A.P., and Bjorkman P.J. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 13 (2000) 727-736
12. Shiroishi M., Kuroki K., Rasubala L., Tsumoto K., Kumagai I., Kurimoto E., Kato K., Kohda D., and Maenaka K. Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Proc. Natl. Acad. Sci. USA 103 (2006) 16412-16417
13. Shiroishi M., Kajikawa M., Kuroki K., Ose T., Kohda D., and Maenaka K. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). J. Biol. Chem. 281 (2006) 19536-19544
14. Nakajima H., Samaridis J., Angman L., and Colonna M. Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain. J. Immunol. 162 (1999) 5-8
15. Tedla N., Bandeira-Melo C., Tassinari P., Sloane D.E., Samplaski M., Cosman D., Borges L., Weller P.F., and Arm J.P. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc. Natl. Acad. Sci. USA 100 (2003) 1174-1179
16. Sloane D.E., Tedla N., Awoniyi M., Macglashan Jr. D.W., Borges L., Austen K.F., and Arm J.P. Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 104 (2004) 2832-2839
17. Huynh O.A., Hampartzoumian T., Arm J.P., Hunt J., Borges L., Ahern M., Smith M., Geczy C.L., McNeil H.P., and Tedla N. Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 46 (2007) 742-751
18. O'Callaghan C.A., Byford M.F., Wyer J.R., Willcox B.E., Jakobsen B.K., McMichael A.J., and Bell J.I. BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation. Anal. Biochem. 266 (1999) 9-15
19. Gao G.F., Tormo J., Gerth U.C., Wyer J.R., McMichael A.J., Stuart D.I., Bell J.I., Jones E.Y., and Jakobsen B.K. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature 387 (1997) 630-634
20. Garner L.I., Salim M., Mohammed F., and Willcox B.E. Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies. Protein Expr. Purif. 47 (2006) 490-497
21. Garboczi D.N., Hung D.T., and Wiley D.C. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc. Natl. Acad. Sci. USA 89 (1992) 3429-3433
22. Zhu J., Jiang X., Liu Y., Tien P., and Gao G.F. Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. J. Mol. Biol. 354 (2005) 601-613
23. Ahmed A.R., Olivier G.W., Adams G., Erskine M.E., Kinsman R.G., Branch S.K., Moss S.H., Notarianni L.J., and Pouton C.W. Isolation and partial purification of a melanocyte-stimulating hormone receptor from B16 murine melanoma cells. A novel approach using a cleavable biotinylated photoactivated ligand and streptavidin-coated magnetic beads. Biochem. J. 286 Pt. 2 (1992) 377-382
24. Otwinowski Z., and Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276 (1997) 307-326
25. Collaborative Computational Project Number 4(CCP4), The CCP4 suite: Programs for protein crystallography, Acta cryst. D 50 (1994) 760-763. Available from:.
26. Cole D.K., Rizkallah P.J., Boulter J.M., Sami M., Vuidepot A.L., Glick M., Gao F., Bell J.I., Jakobsen B.K., and Gao G.F. Computational design and crystal structure of an enhanced affinity mutant human CD8 alpha(alpha) coreceptor. Proteins 67 (2007) 65-74
27. Clements C.S., Kjer-Nielsen L., Kostenko L., Hoare H.L., Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn J., and McCluskey J. Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proc. Natl. Acad. Sci. USA 102 (2005) 3360-3365
28. Heinz D.W., and Matthews B.W. Rapid crystallization of T4 lysozyme by intermolecular disulfide cross-linking. Protein Eng. 7 (1994) 301-307
29. Shiroishi M., Kuroki K., Tsumoto K., Yokota A., Sasaki T., Amano K., Shimojima T., Shirakihara Y., Rasubala L., van der Merwe P.A., Kumagai I., Kohda D., and Maenaka K. Entropically driven MHC class I recognition by human inhibitory receptor leukocyte ig-like receptor B1 (LILRB1/ILT2/CD85j). J. Mol. Biol. 355 (2006) 237-248
30. Brown M.H., Preston S., and Barclay A.N. A sensitive assay for detecting low-affinity interactions at the cell surface reveals no additional ligands for the adhesion pair rat CD2 and CD48. Eur. J. Immunol. 25 (1995) 3222-3228
31. Braud V.M., Allan D.S., O'Callaghan C.A., Soderstrom K., D'Andrea A., Ogg G.S., Lazetic S., Young N.T., Bell J.I., Phillips J.H., Lanier L.L., and McMichael A.J. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391 (1998) 795-799
32. Vaguine A.A., Richelle J., and Wodak S.J. SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model. Acta Crystallogr. D Biol. Crystallogr. 55 (1999) 191-205
33. Bond C.S. TopDraw: a sketchpad for protein structure topology cartoons. Bioinformatics 19 (2003) 311-312