Physical map and one-megabase sequencing of the human immunoglobulin lambda locus

Genetics and Molecular Biology

Volumn 21, Issue 2, 1998, Pages 281-286

  Passos Jr , Geraldo A S ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Faculdade Odontol de Ribeirao Preto   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

CHROMOSOME 22Q; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; HUMAN; IMMUNOGENETICS; REVIEW;

EID: 3543131247     PISSN: 14154757     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1415-47571998000200019     Document Type: Review

References (33)

1. Alexandre, D., Chuchana, P., Brockly, F., Blancher, A., Lefranc, G. and Lefranc, M.-P. (1989). First genomic sequence of a human Ig variable λ gene belonging to subgroup I: functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus. Nucleic Acids Res. 17: 3975.
2. Anderson, M.L.M., Szajnert, M.F., Kaplan, J.C., McColl, L. and Young, B.D. (1984). The isolation of a human Ig Vλ gene from a recombinant library of chromosome 22 and estimation of its copy number. Nucleic Acids Res. 12: 6647-6661.
3. Bauer Jr., S.R. and Blomberg, B. (1991). Recharacterization of JC lambda 6 and identification of a functional JC lambda 7. J. Immunol. 146: 2813-2820.
4. Bernard, F., Chuchana, P., Frippiat, J.-P., Buluwela, L. and Lefranc, M.-P. (1990). Genomic sequence of IGLV1S2, a human immunoglobulin variable lambda gene belonging to subgroup I. Nucleic Acids Res. 18: 7139.
5. Brockly, F., Alexandre, D., Chuchana, P., Huck, S., Lefranc, G. and Lefranc, M.-P. (1989). First nucleotide sequence of a human immunoglobulin variable λ gene belonging to subgroup II. Nucleic Acids Res. 17: 3976.
6. Chuchana, P., Blancher, A., Brockly, F., Alexandre, D., Lefranc, G. and Lefranc, M.-P. (1990). Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups. Eur. J. Immunol. 20: 1317-1325.
7. Combriato, G. and Klobeck, H.-G. (1991). Vλ and Jλ-Cλ genes of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 21: 1513-1522.
8. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genet. 7: 162-168.
9. Daley, M.D., Olee, T., Peng, H.-Q., Soto-Gil, R.W., Chen, P.P. and Siminovitch, K.A. (1992a). Molecular characterisation of the human immunoglobulin VλI germline gene repertoire. Mol. Immunol. 29: 1031-1042.
10. Daley, M.D., Peng, H.-Q., Misener, V., Liu, X.-Y., Chen, P.P. and Siminovitch, K.A. (1992b). Molecular analysis of human immunoglobulin Vλ germline genes: subgroups VλIII and VλIV. Mol. Immunol. 29: 1515-1518.
11. - λ chain and Cλ4 and Cλ5 are pseudogenes. Proc. Natl. Acad. Sci. USA 84: 9074-9078.
12. de la Chapelle A., Lenoir, A., Boue, G., Gallano, P., Huerre, C., Szajnert, M.F., Jeanpierre, M., Lalouel, M. and Kaplan, J.C. (1983). Lambda Ig constant region genes are translocated to chromosome 8 in a Burkitt's lymphoma (8,22). Nucleic Acids Res. 11: 1133-1142.
13. Frippiat, J.-P., Chuchana, P., Bernard, F., Buluwela, L., Lefranc, G. and Lefranc, M.-P. (1990). First genomic sequence of a human Ig variable lambda gene belonging to subgroup III. Nucleic Acids Res. 18: 7134.
14. Frippiat, J.-P., Williams, S.C., Tomlinson, I.M., Cook, G.P., Cherif, D., Le Paslier, D., Collins, J.E., Dunham, I., Winter, G. and Lefranc, M.-P. (1995). Organisation of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. Hum. Mol. Genet. 4: 981-983.
15. Frippiat, J.-P., Dard, P., Marsh, S., Winter, G. and Lefranc, M.-P. (1997). Immunoglobulin lambda light chain orphans on human chromosome 8q11.2. Eur. J. Immunol. 27: 1260-1265.
16. Harris, L.J., Larson, S.B., Hasel, K.W., Day, J., Greenwood, A. and McPherson, A. (1992). The three-dimensional structure of an intact monoclonal antibody for canine lymphoma. Nature 360: 369-372.
17. Ignatovich, O., Tomlinson, I.M., Jones, P.T. and Winter, G. (1997). The creation of diversity in the human immunoglobulin Vλ repertoire. J. Mol. Biol. 268: 69-77.
18. Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S. and Foeller, C. (1991). Sequences of Proteins of Immunological Interest. U.S. Department of Health and Human Services, Bethesda, MD, USA.
19. Kawasaki, K., Minoshima, S., Schooler, K., Kudoh, J., Asakawa, S., de Jong, P.J. and Shimizu, N. (1995). The organization of the human immunoglobulin λ gene locus. Genome Res. 5: 125-135.
20. Kawasaki, K., Minoshima, S., Nakato, E., Shibuia, K., Shintani, A., Schmeits, J.L., Wang, J. and Shimizu, N. (1997). One-megabase sequence analysis of the human immunoglobulin lambda gene locus. Genome Res. 7: 250-261.
21. Lai, E., Wilson, R. and Hood, L. (1989). Physical maps of the mouse and human immunoglobulin like loci. Adv. Immunol. 46: 1-59.
22. Mattei, M.-G., Fumoux, F., Roeckel, N., Fougereau, M. and Schiff, C. (1991). The human pre-B-specific λ-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgCλ locus. Genomics 9: 544-546.
23. McBride, O.W., Heiter, P.A. and Hollis, G.F. (1982). Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J. Exp. Med. 155: 1480-1490.
24. Padlan, E. (1994). Anatomy of the antibody molecule. Mol. Immunol. 31: 169-217.
25. Passos Jr., G.A.S., Queiroz, R.G.P. and Brûlé, A. (1997). EcoRI restriction fragment-length polymorphism of the human immunoglobulin variable lambda 8 (IGLV8) subgroup reveals a gene family. Hum. Immunol. 55: 96-102.
26. Queiroz, R.G.P., Carrier, A., Victorero, G., Jordan, B. and Passos Jr., G.A.S. (1997). Chromosomal location of the human immunoglobulin lambda variable 8 (IGLV8) gene family outside the major λ locus on chromosome 22q 11.2. Immunol. Lett. 59: 177-180.
27. Rowen, L., Koop, B.F. and Hood, L. (1996). The complete 685-kb DNA sequence of the human β T-cell receptor locus. Science 272: 1755-1762.
28. Siminovitch, K.A., Misener, V., Kwong, P.C., Song, Q.-L. and Chen, P.P. (1989). A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation. J. Clin. Invest. 84: 1675-1678.
29. Stiernholm, N.B.J., Kusniar, B. and Berinstein, N. (1994). Identification of a new human Vλ gene family Vλ X. J. Immunol. 152: 4969-4975.
30. Vasicek, T.J. and Leder, P. (1990). Structure and expression of the human immunoglobulin λ genes. J. Exp. Med. 172: 609-620.
31. Winkler, T.H., Fehr, H. and Kalden, J. (1992). Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22: 1719-1728.
32. Williams, S.C. and Winter, G. (1993). Cloning and sequencing of human immunoglobulin Vλ segments. Eur. J. Immunol. 23: 1456-1461.
33. Zachau, H.G. (1993). The immunoglobulin κ locus - or what has been learned from looking closely at one-tenth of a percent of the human genome. Gene 135: 167-173.