Microcirculation and microvasculature in breast tumors: Pharmacokinetic analysis of dynamic MR image series

Magnetic Resonance in Medicine

Volumn 52, Issue 2, 2004, Pages 420-429

  Brix, Gunnar ^a   Kiessling, Fabian ^b   Lucht, Robert ^a   Darai, Susanne ^c   Wasser, Klaus ^b   Delorme, Stefan ^b   Griebel, Jürgen ^a  

^a BUNDESAMT FÜR STRAHLENSCHUTZ   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Blood flow; Breast tumors; Capillary permeability; Contrast media; Dynamic MRI

Indexed keywords

BLOOD; BLOOD VESSELS; CONTRAST MEDIA; DIAGNOSIS; MAGNETIC RESONANCE IMAGING; MICROCIRCULATION; MUSCLE; PATIENT REHABILITATION; PATIENT TREATMENT; PHARMACOKINETICS; TUMORS;

BLOOD FLOW; BREAST TUMOR; DYNAMIC MRI; FUNCTIONAL IMAGING; PHARMACOKINETIC ANALYSIS; THERAPY MANAGEMENT; TRANSFER COEFFICIENT; TWO-COMPARTMENT MODELS;

MEDICAL IMAGING;

CAI 626P/TOMOJET; GADOLINIUM PENTETATE;

ADULT; AGED; ARTICLE; BLOOD FLOW; BREAST TUMOR; CAPILLARY PERMEABILITY; CLINICAL ARTICLE; COMPARTMENT MODEL; DEVICE; DIAGNOSTIC IMAGING; FEMALE; HUMAN; MICROCIRCULATION; MICROVASCULATURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PECTORAL MUSCLE; PLASMA VOLUME;

EID: 3543112698     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20161     Document Type: Article

References (37)

1. Harms SE, Flamig DP. Breast MRI. Clin Imag 2001;25:227-246.
2. Morris EA. Breast cancer imaging with MRI. Radiol Clin North Am 2002;40:443-466.
3. Schnall MD. Breast MR imaging. Radiol Clin North Am 2003;41:43-50.
4. Kuhl CK, Mielcareck P, Klaschik S, Leutner C, Wardelmann E, Gieseke J, Schild HH. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 1999;211:101-110.
5. Knopp MV, Weiss E, Sinn HP, Mattern J, Junkermann H, Radeleff J, Magener A, Brix G, Delorme S, Zuna I, van Kaick G. Pathophysiologic basis of contrast enhancement in breast tumors. J Magn Reson Imag 1999;10:260-266.
6. Vaupel P, Höckel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers. Characterization and therapeutic relevance. Int J Oncol 2000;17:869-879.
7. Hoffmann U, Brix G, Knopp MY, Heß Th, Lorenz WJ. Pharmacokinetic mapping of the breast: a new method for dynamic MR mammography. Magn Reson Med 1995;33:506-514.
8. Tofts PS, Berkowitz B, Schnall MD. Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model. Magn Reson Med 1995;33:564-568.
9. Hulka CA, Smith BL, Sgroi DC, Tan L, Edmister WB, Semple JP, Campbell T, Kopans DB, Brady TJ, Weisskoff RM. Benign and malignant breast lesions: differentiation with echo-planar MR imaging. Radiology 1995;197:33-38.
10. Hulka CA, Edmister WB, Smith BL, Tan LT, Sgroi DC, Campbell T, Kopans DB, Weisskoff RM. Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis. Radiology 1997;205:837-842.
11. den Boer JA, Hoenderop RKKM, Smink J, Dornseiffen G, Koch PWAA, Mulder JH, Slump CH, Volker EDP, de Vos RAI. Pharmacokinetic analysis of Gd-DTPA enhancement in dynamic three-dimensional MRI of breast lesions. J Magn Reson Imag 1997;7:702-715.
12. Daldrup HE, Shames DM, Husseini W, Wendland MF, Okuhata Y, Brasch RC. Quantification of the extraction fraction for gadopentetate across breast cancer capillaries. Magn Reson Med 1998;40:537-543.
13. Port RE, Knopp MV, Hoffmann U, Zabel S, Brix G. Multicompartment analysis of gadolinium chelate kinetics: blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging. J Magn Reson Imag 1999;10:233-241.
14. Henderson E, Sykes J, Drost D, Weinmann HJ, Rutt BR, Lee TY. Simultaneous MRI measurements of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents. J Magn Reson Imag 2000;12:991-1003.
15. Delille JD, Slanetz PJ, Yeh ED, Kopans DB, Garrido L. Breast cancer: regional blood flow and blood volume measured with magnetic susceptibility-based MR imaging - initial results. Radiology 2002;223:558-565.
16. Brix G, Bahner M, Hoffmann U, Horvath A, Schreiber W. Regional blood flow, capillary permeability, and compartment volumes: Measurement with dynamic computed tomography - initial experience. Radiology 1999;210:269-276.
17. Stepanow B, Blüml S, Brix G, Schad LR, Lorenz WJ. Comparison of T1 measurements by means of TurboFLASH techniques performed on a conventional whole-body MR Imager. SMRM, 12th Scientific Meeting, 1993, Book of Abstracts, 2:742.
18. Donahue KM, Weisskoff RM, Burstein D. Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imag 1997;7:102-110.
19. Mørkenborg J, Taaghehøj JF, Væver PN, Frøkær, Djurhuus JC, Stødkilde-Jørgensen H. In vivo measurement of T1 and T2 relaxivities in the kidney cortex of the pig-based on a two-compartment steady-state model. Magn Reson Imag 1998;16:933-942.
20. Eisenfeld J. On mean residence times in compartments. Math Biosci 1981;57:265-278.
21. García-Meseguer MJ, Vidal de Labra JA, García-Moreno M, García-Cánovas F, Havsteen BH, Varón R. Mean residence times in linear compartmental systems. Symbolic formulae for their direct evaluation. Bull Math Biol 2003;65:279-308.
22. Barth M, Moser E. Proton NMR relaxation times of human blood samples at 1.5 T and implications for functional MRI. Cell Mol Biol 1997;43:783-791.
23. Stanisz GJ, Henkelman RM. Gd-DTPA relaxivity depends on macromolecular content. Magn Reson Med 2000;44:665-667.
24. Lightfoot EN, Duca KA. The roles of mass transfer in tissue function. In: Bronzino JE, editor in chief. The biomedical engineering handbook, vol 2. Boca Raton, FL: CRC Press; 2000.
25. Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 1991;51:265-273.
26. Weiss TF. Cellular biophysics, vol. 1. Transport. Cambridge, MA: MIT Press; 1995.
27. Bassingthwaighte JB. A concurrent flow model for extraction during transcapillary passage. Circ Res 1974;35:483-503.
28. Moran GR, Prato FS. Modeling tissue contrast agent concentration: a solution to the tissue homogeneity model using a simulated arterial input function. Magn Reson Med 2001;45:42-45.
29. Bassingthwaighte JB, Goresky CA. Modelling in the analysis of solute and water exchange in the microvasculature. In: Renkin EM, Michel CC. Geiger SR, editors. Handbook of physiology, vol. IV. sect. 2. Bethesda, MD: American Physiology Society; 1984. p 549-626.
30. Gullino PM, Grantham FH, Smith SH. The interstitial water space of tumors. Cancer Res 1965;25:727-731.
31. O'Connor SW, Bale WF. Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors. Cancer Res 1984;44:3719-3723.
32. Appelgren L, Peterson HI, Rosengren B. Vascular and extravascular spaces in two transplantable tumors of the rat. Bibl Anat 1973;12:504-510.
33. Jain RK. Transport of molecules across tumor vasculature. Cancer Metast Rev 1987;6:559-593.
34. Zasadny KR, Tatsumi M, Wahl RL. FDG metabolism and uptake versus blood flow in women with untreated primary breast cancers. Eur J Nucl Med 2003;30:274-280.
35. Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Schubert EK, Tseng J, Lawton TJ, Linden HM, Livingston RB. Changes in blood flow and metabolism in locally advanced breast cancer treated with neoadjuvant chemotherapy. J Nucl Med 2003;44:1806-1814.
36. Peters AM, Myers MJ. Physiological measurements with radionuclides in clinical practice. Oxford: Oxford University Press; 1998. p 43.
37. Jain RK. Delivery of molecular and cellular medicine to solid tumors. Microcirculation 1997;4:1-23.