Role of epidermal growth factor (EGF) in oesophageal mucosal integrity

Current Medical Research and Opinion

Volumn 14, Issue 3, 1998, Pages 145-153

  Grabowska, S Z ^a   Czyzewska, E ^b   Marcinkiewicz, Marek ^b,c  

^a SP ZOZ Wojewodzki Szpital Zespolony im J Sniadeckiego w Białymstoku   (Poland)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^c Medical School   (Poland)

Author keywords

Epidermal growth factor; Oesophageal mucosa; Saliva

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PEPSIN A;

AUTOPHOSPHORYLATION; BARRETT ESOPHAGUS; ESOPHAGUS INJURY; ESOPHAGUS MUCOSA; GASTROESOPHAGEAL REFLUX; MITOSIS RATE; REVIEW; SALIVA; SALIVARY GLAND; SIGNAL TRANSDUCTION;

EID: 3543101483     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/03007999809113354     Document Type: Review

References (69)

1. Li, L., Yu, Z., Piascik, R., Hetzel, D. P., Rourk, R. M., Namiot, Z., Sarosiek, J. and McCallum, R. W. (1993). Effect of esophageal intraluminal mechanical and chemical stressors on salivary epidermal growth factor in humans. Am. J. Gastroenterol., 88, 1749-1755.
2. Rourk, R. M., Namiot, Z., Sarosiek, J., Yu, Z. and McCallum, R. W. (1994). Impairment of salivary epidermal growth factor secretory response to esophageal mechanical and chemical stimulation in patients with reflux esophagitis. Am. J. Gastroenterol., 89, 237-244.
3. Namiot, Z., Rourk, R. M., Piascik, R., Hetzel, D. P., Sarosiek, J. and McCallum, R. W. (1994). Interrelationship between esophageal challenge with mechanical and chemical stimuli and salivary protective mechanisms. Am. J. Gastroenterol., 89, 581-587.
4. Sarosiek, J., Rourk, R. M. , Piascik, R., Namiot, Z., Hetzel, D. P. and McCallum, R. W. (1994). The effect of esophageal mechanical and chemical stimuli on salivary mucin secretion in healthy individuals. Am. J. Med. Sci., 308, 23-31.
5. Korsten, M. A., Rosman, A. S., Fishbein, S., Shlein, R. D., Goldberg, H. E. and Biener, A. (1991). Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. Am. J. Med., 90, 701-706.
6. Marcinkiewicz, M., Sarosiek, J., Edmunds, M. C., Namiot, Z. and McCallum, R. W. (1996). Detrimental impact of acid and pepsin on the rate of luminal release of transforming growth factor alpha: Its potential pathogenetic role in the development of reflux esophagitis. J. Clin. Gastroenterol., 22, 261-269.
7. Marti, U., Burwen, S. J. and Jones, A. L. (1989). Biological effects of epidermal growth factor with emphasis on the gastrointestinal tract and liver: An update. Hepatology, 9, 126-138.
8. Barnard, J. A., Beauchamp, R. D., Russell, W. E., Dubois, R. N. and Coffey, R. J. (1995). Epidermal growth factor-related peptides and their relevance to gastrointestinal physiology. Gastroenterology, 108, 564-580.
9. Sarosiek, J., Feng, T. and McCallum, R. W. (1991). The interrelationship between salivary epidermal growth factor and the functional integrity of the esophageal mucosal barrier in the rat. Am. J. Med. Sci., 302, 359-363.
10. Marcinkiewicz, M., Van der Linden, B., Peura, D. A., Goldin, G., Parolisi, S. and Sarosiek, J. (1996). Impact of Helicobacter pylori colonization on immunoreactive epidermal growth factor and transforming growth factor-α in gastric juice. Its potential pathogenic implications. Dig. Dis. Sci., 41, 2150-2155.
11. Konturek, P. K., Brzozowski, T., Konturek, S. J. and Dembinski, A. (1990). Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress induced gastric lesions. Gastroenlerology, 99, 1607-1615.
12. Jankowski, J., Hopwood, D. and Wormsley, K. G. (1993). Expression of epidermal growth factor, transforming growth factor alpha and their receptor in gastro-oesophageal diseases. Dig. Dis., 11, 1-11.
13. Carpenter, G. and Cohen, S. (1990). Epidermal growth factor. J. Biol. Chem., 265, 7709-7712.
14. Cooke, R. M., Wilkinson, A. J., Baron, M., Pastore, A., Tappin, M. J., Campbell, I. D., Gregory, H. and Sheard, B. (1987). The solution structure of human epidermal growth factor. Nature, 327, 339-341.
15. 1H-n.m.r. assignments and peptide backbone conformation in rat epidermal growth factor. Biochem. J., 257, 197-205.
16. Todderud, G. and Carpenter, G. (1989). Epidermal growth factor: The receptor and its function. Biofactors, 2, 11-15.
17. Laurence, D. J. R. and Gusterson, B. A. (1990). The epidermal growth factor. Tumor Biol. 11, 229-261.
18. Velu, T. J., Beguinot, L., Vass, W. C. and Willingham, M. C. (1987). Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science, 238, 1408-1410.
19. Carpenter, G. (1984). Properties of the receptor for epidermal growth factor. Cell 37, 357-358.
20. Downward, J., Parker, P. and Waterfield, M. D. (1984). Autophosphorylation sites on the epidermal growth factor receptor. Nature, 311, 483-485.
21. Margolis, B. L., Lax, I., Kris, R., Dombalagian, M., Honegger, A. M., Howk, R., Givol, D., Ullrich, A. and Schlessinger J. (1989), All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. J. Biol. Chem., 264, 10667-10671.
22. Russo, M. W., Lukas, T. J., Cohen, S. and Staros, J. V. (1985). Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/ kinase. J. Biol. Chem., 260, 5205-5208.
23. Gozes, I. and Littauer, U. Z. (1978). Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro. Nature, 276, 409-410.
24. Ushiro, H. and Cohen, S. (1980). Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J. Biol. Chem., 255, 8363-8365.
25. Coffer, P. J. and Kruijer, W. (1995). EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem. Biophys. Res. Commun., 210, 74-81.
26. Spitzer, E., Zschiesche, W., Binas, B., Grosse, R. and Erdmann, B. (1995). EGF and TGF alpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: possible role of the arachidonic acid pathway. J. Cell. Biochem., 57, 495-508.
27. Gilligan, A., Prentki, E. and Knowles, B. B. (1990). EGF receptor down-regulation attenuates ligand-induced second messenger formation. Exp. Cell. Res., 187, 134-142.
28. Johnson, R. M. and Garrison, J. C. (1987). Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate. J. Biol. Chem., 262, 17285-17293.
29. Wahl, M. and Carpenter, G. (1988). Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. J. Biol. Chem., 263, 7581-7590.
30. Davis, R. J. (1988). Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity. J. Biol. Chem., 263, 9462-9469.
31. Konturek, J. W., Bielanski, W., Konturek, S. J., Bogdal, J. and Oleksy, J. (1989). Distribution and release of epidermal growth factor in man. Gut, 30, 1194-1200.
32. Goldin, F. G., Marcinkiewicz, M., Zbroch, T., Bityutskiy, L. R, McCallum, R. W. and Sarosiek, J. (1997). Esophagoprotective potential of cisapride. An additional benefit for gastroesophageal reflux disease. Dig. Dis. Sci., 42, 1362-1369.
33. Skov Olsen, P., Kirkegaard, P., Poulsen, S. S. and Nexo, E. (1984). Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. Gut, 25, 1234-1240.
34. Konturek, P. Ch., Ernst, H., Konturek, J., Bobrzynski, A., Kwiecien, N., Faller, G., Gedliczka, O. and Hahn, E. G. (1996). Salivary and luminal release of epidermal growth factor under basal conditions and after pentagastrin stimulation in healthy subjects and in duodenal ulcer patients before and after eradication of Helicobacter pylori. J. Physiol. Pharmacol., 47, 187-194.
35. Sarosiek, J., Scheurich, C. J., Marcinkiewicz, M. and McCallum, R. W. (1996). Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease. Gastroenterology, 110, 675-681.
36. Marcinkiewicz, M., Schriber, J. P., Scheurich, J., Edmunds, M. C., McCallum, R. W. and Sarosiek, J. (1996). Salivary bicarbonate and non-bicarbonate buffering capacity, mediated by esophago-salivary reflex, in patients with reflux esophagitis, Gastroenterology, 110, A186.
37. Sarosiek, J. and McCallum, R. W. (1995). What role do salivary inorganic components play in health and disease of the esophageal mucosa? Digestion, 56 (Suppl 1), 24-31.
38. Dutta, S. K., Matossian, H. B., Meirowitz, R. F. and Vaeth, J. (1992). Modulation of salivary secretion by acid infusion in the distal esophagus in humans. Gastroenterology, 103, 1833-1841.
39. Marcinkiewicz, M., Sarosiek, J., Scheurich, J. and McCallum, R. W. (1995). Is human salivary bicarbonate secretion mediated by esophago-salivary reflex? Am. J. Gastroenterol., 90, 1564.
40. Marcinkiewicz, M., Namiot, Z., Sarosiek, J. and McCallum, R.W. (1995). Modulation of salivary prostaglandin E2 secretion by intraesophageal mucosal changes in patients with reflux esophagitis. Gastroenterology, 108, A158.
41. Marcinkiewicz, M., Zbroch, T., Scheurich, J., Sarosiek, J. and McCallum, R. W. (1997). Potential contribution of enhanced salivary epidermal growth factor output to the lower prevalence of reflux esophagitis and complications in African-Americans. Gastroenterology, 112, A211.
42. Hradky, M., Hybasek, I., Cernoch, V. and Juran, J. (1967). Esophageal abnormalities in Sjögren's syndrome. Scand. J. Gastroenterol., 2, 200-203
43. Ramirez-Mata, M., Pena-Ancira, F. F. and Alarcon-Segovia, D. (1976). Abnormal esophageal motility in primary Sjögren's syndrome. J. Rheumatol., 3, 63-69.
44. Simila, S., Kokkonen, J. and Kaski, M. (1978). Achalasia Sicca-Juvenile Sjögren's syndrome with achalasia and gastric hyposecretion. Eur. J. Pediatr., 175, 175-181.
45. McGurk, M., Hanford, L., Justice, S. and Metcalf, R. A. (1990). The secretory characteristics of epidermal growth factor in human saliva. Arch. Oral. Biol., 35, 653-659.
46. Tuchman, D. N., Dutta, S. K., Vengurlekar, S. M., Gottal, R., Bidani, J. A. and Dutta, D. (1992). Reduction of salivary epidermal growth factor (EGF) secretion and alteration in EGF receptor expression in esophageal mucosa in pediatric patients with reflux esophagitis. Gastroenterology, 102, A182.
47. Gray, M. R., Donnelly, R. J. and Kingsnorth, A. N. (1991). Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus. Br. J. Surg., 78, 1461-1466.
48. Sakai, Y., Nelson, K. G., Snedeker, S., Bossert, N. L., Walker, M. P., McLachlan, J. and Di Augustine, R. P (1994). Expression of epidermal growth factor in suprabasal cells of stratified squamous epithelia: implications for a role in differentiation. Cell. Growth. Differ., 5, 527-535.
49. Hamilton, B. H. and Orlando, R. C. (1989). In vivo alkaline secretion by mammalian esophagus. Gastroenterology, 97, 640-648.
50. Sarosiek, J., Hetzel, D. P., Yu, Z., Piascik, R., Li, L., Rourk, R. M. and McCallum, R. W. (1993). Evidence on secretion of epidermal growth factor by the esophageal mucosa in humans. Am. J. Gastroenterol., 188, 1081-1087.
51. Marcinkiewicz, M., Sarosiek, J., Edmunds, M., Scheurich, J., Weiss, P. and McCallum, R. W. (1995). Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance. J. Clin. Gastroenterol., 21, 268-274.
52. Jankowski, J., Coghill, G., Tregaskis, B., Hopwood, D. and Wormsley, K. G. (1992). Epidermal growth factor in the oesophagus. Gut, 33, 1448-1453.
53. Oka, Y. and Orth, D. N. (1983). Human plasma epidermal growth factor/beta urogastrone is associated with blood platelets. J. Clin. Invest., 72, 249-259.
54. Livstone, E., Sheahan, S. and Behar, J. (1977). Studies of esophageal cell proliferation in patients with reflux esophagitis. Gastroenterology, 73, 1315-1319.
55. Jankowski, J., McMennemin, R., Hopwood, D., Penston, J. G. and Wormsley, K. G. (1991). Abnormal expression of growth regulatory peptides in Barrett's oesophagus. Clin. Sci., 81, 663-668.
56. Dutta, S. K., Meirowitz, R. F., Vengurlekar, S. and Resau, J. (1990). Localization and characterization of epidermal growth factor receptors in human oesophageal epithelium. Gastroenterology, 98, A38.
57. Jankowski, J., Murphy, S., Coghill, G., Grant, A., Hopwood, D. and Wormsley, K. G. (1992). Expression of epidermal growth factor receptors in oesophageal mucosa. Gut, 33, 439-443.
58. Hsuan, J. J., Totty, N. and Waterfield, M. D. (1989). Identification of a novel auto-phosphorylation site (P4) on the epidermal growth factor receptor. Biochem. J., 262, 659-663.
59. Fehlman, E. J., Anres, D. and Grossman, M. I. (1978). Epidermal growth factor stimulates ornithine decarboxylase activity in the digestive tract of mouse. Proc. Soc. Exp. Biol. Med., 159, 400-402.
60. Konturek, S. J., Radecki, T., Brzozowski, T, Piastucki, I., Dembinski, A., Dembinska-Kiec, A., Zmuda, A., Gryglewski, R. and Gregory, H. (1981). Gastric cytoprotection by epidermal growth factor: Role of endogenous prostaglandins and DNA synthesis. Gastroenterology, 81, 438-443.
61. Chen, L. B., Gudor, R. C. and Sun, T. T. (1977). Control of a cell surface major glycoprotein by epidermal growth factor. Science, 197, 776-778.
62. + exchange: What, where and why? Hepatology, 8, 960-965.
63. Gullick, W. J. and Lemoine, N. R. (1990). EGF receptor antibody 29.1.1. J. Pathol., 162, 275-276.
64. Benamouzig, R., Ferriere, F., Guettier, C., Amouroux, J., Coste, T. and Rautureau, J. (1996). Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers. Dig. Dis. Sci., 41, 1595-1599.
65. Koretz, K., Schlag, P. and Moller, P. (1990). Expression of epidermal growth factor receptor in normal colorectal mucosa. Adenoma and carcinoma. Virchows Arch. A. Pathol. Anat. Histopathol., 416, 343-349.
66. Vinter-Jensen, L., Orlof Juhl, C., Eika, B., Gregersen, H. and Dajani, E. Z. (1995). Epidermal growth factor attenuates the sclerotherapy-induced biomechanical properties of the oesophagus. Scand. J. Gastroenterol., 30, 614-619.
67. Edmunds, M. C., Namiot, Z., Sarosiek, J., Rourk, R. M., Yu, Z. and McCallum, R. W. (1994). Esophageal epidermal growth factor impairment persists despite healing of endoscopic changes in patients with reflux esophagitis. Gastroenterology, 106, A73.
68. Sarosiek, J., Edmunds, M. C., Namiot, Z., Marcinkiewicz, M. and McCallum, R. W. (1994). Secretory profile of Barrett's esophagus in humans: Its significantly modified protective potential. Gastroenterol., 106, A173.
69. Gilchrist, W., Burkhalter, E., Eaton, C., Schaudies, P. R., Maydonovitch, C., Andrada, R, Maged, A. R., Roy, K. H. and Wong, R. K. H. (1994) The effect of indomethacin on the secretion of human salivary epidermal growth factor. Am. J. Gastroenterol., 89, 97-100.