A novel pattern (sW195a) in surface gene of HBV DNA due to YSDD (L180M plus M204S) mutation selected during lamivudine therapy and successful treatment with adefovir dipivoxil [1]

Journal of Clinical Virology

Volumn 31, Issue 1, 2004, Pages 76-77

  Bozdayi, A Mithat ^a   Eyigun, Can Polat ^b   Turkyilmaz, Ahmet R ^a   Avci, Ismail Yasar ^b   Pahsa, Alaaddin ^b   Yurdaydin, Cihan ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; LAMIVUDINE; METHIONINE; SERINE; TRYPTOPHAN; VALINE; VIRUS DNA;

ADULT; AMINO ACID SEQUENCE; CASE REPORT; GENE MUTATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LETTER; LIVER BIOPSY; MALE; PRIORITY JOURNAL; PROTEIN DOMAIN; TREATMENT OUTCOME;

EID: 3543089847     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2004.05.002     Document Type: Article

References (4)

1. Bozdayi A.M., Uzunalimoglu O., Turkyilmaz A.R., Aslan N., Sezgin O., Sahin T., Bozdayi G., Cinar K., Pai S.B., Pai R., Bozkaya H., Karayalcin S., Yurdaydin C., Schinazi R.F. YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine. J Viral Hepat. 10:2003;256-265
2. Knodell R.G., Ishak K.G., Black W.C., Chen T.S., Craig R., Kaplowitz N., Kiernan T.W., Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1:1981;431-435
3. Niesters H.G., De Man R.A., Pas S.D., Fries E., Osterhaus A.D. Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy. J Med Microbiol. 51:2002;695-699
4. Ogata N., Fujii K., Takigawa S., Nomoto M., Ichida T., Asakura H. Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in Japanese patients with chronic hepatitis B. J Med Virol. 59:1999;270-276