Changes to levels of DNA damage and apoptotic resistance in peripheral blood mononuclear cells and plasma antioxidant potential with age in Labrador Retriever dogs

Journal of Nutrition

Volumn 134, Issue 8 SUPPL., 2004, Pages

  Blount, Daniel G ^a,b   Heaton, Paul R ^a   Pritchard, David I ^b  

^a WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Aging; Apoptosis; Canine; DNA damage; Oxidative stress

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL CYCLE; CELL DIVISION; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DOG; FEMALE; IMMUNITY; MALE; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL;

ANIMALIA; CANIS FAMILIARIS;

EID: 3543075182     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.8.2120s     Document Type: Conference Paper

References (20)

1. Franceschi, C., Monti, D., Barbieri, D., Grassilli, E., Troiano, L., Salvioli, S., Negro, P., Capri, M., Guido, M., Azzi, R., Sansoni, P., Paganelli, R., Fagiolo, U., Baggio, G., Donazzan, S., Mariotti, S., D'Addato, S., Gaddi, A., Ortolani, C. & Cossarizza, A. (1995) Immunosenescence in humans: deterioration or remodelling? Int. Rev. Immunol. 12: 57-74.
2. Globerson, A. & Effros, R. B. (2000) Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today 21: 515-519.
3. Castle, S. C. (2000) Clinical relevance of age-related immune dysfunction. Clin. Infect. Dis. 31: 578-585.
4. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
5. Knight, J. A. (2001) The biochemistry of aging. Adv. Clin. Chem. 35: 1-62.
6. Hildeman, D. A., Mitchell, T., Teague, T. K., Henson, P., Day, B. J., Kappler, J. & Marrack, P. C. (1999) Reactive oxygen species regulate activation induced T cell apoptosis. Immunity 10: 735-744.
7. Wertz, I. E. & Hanley, M. R. (1996) Diverse molecular provocation of programmed cell death. Trends Biochem. Sci. 21: 359-364.
8. Blount, D. G., Heaton, P. R. & Pritchard, D. I. (2003) Age-related changes to immune parameters in Labrador retriever dogs. JVIM 17: 420 (abs.).
9. Heaton, P. R., Blount, D. G., Devlin, P., Koelsch, S., Mann, S. J., Smith, B. H. E., Stevenson, J. & Harper, E. J. (2002) Assessing age-related changes in peripheral blood leukocyte phenotypes in Labrador retriever dogs using flow cytometry. J. Nutr. 132: 1655S-1657S.
10. von Zglinicki, T., Burkle, A. & Kirkwood, T. B. L. (2001) Stress, DNA damage and ageing - an integrative approach. Exp. Gerontol. 36: 1049-1062.
11. Wayne, S. J., Rhyne, R. L., Garry, P. J. & Goodwin, J. S. (1990) Cell-mediated-immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol. 45: M45-M48.
12. Ferguson, F. G., Wikby, A., Maxson, P., Olsson, J. & Johansson, B. (1995) Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J. Gerontol. 50A: B378-B382.
13. Goldsby, R. A., Kindt, T. J. & Osborne, B. A. (2000) Kuby Immunology Fourth Edition. W.H. Freeman, New York, NY.
14. Castedo, M., Macho, A., Zamzami, N., Hirsch, T., Marchetti, P., Uriel, J. & Kroemer, G. (1995) Mitochondrial pertubations define lymphocytes undergoing apoptotic depletion in vivo. Eur. J. Immunol. 25: 3277-3284.
15. Loveridge, G. (1994) Provision of environmentally enriched housing for dogs. Anim. Technol. 199: 1311-1315.
16. Benzie, I. F. F. & Strain, J. J. (1999) Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. In: Methods in Enzymology: Oxidants and Antioxidants, Part A, Vol. 299. (Packer, L., ed.), p. 15-27. Academic Press, New York, NY.
17. Heaton, P. R., Ransley, R., Charlton, C. J., Mann, S. J., Stevenson, J., Smith, B. H. E., Rawlings, J. M. & Harper, E. J. (2002) Application of single-cell gel electrophoresis (comet) assay for assessing levels of DNA damage in canine and feline leukocytes. J. Nutr. 132: 1598S-1603S.
18. Sasaki, M., Kumazaki, T., Takano, H., Nishiyama, M. & Mitsui, Y. (2001) Senescent cells are resistant to death despite low Bcl-2 level. Mech. Ageing Dev. 122: 1695-1706.
19. Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L. & Moss, P. A. H. (2002) Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169: 1984-1992.
20. Franceschi, C., Bonafe, M. & Valensin, S. (2000) Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18: 1717-1720.