Efficient synthesis of doxorubicin melanotransferrin p97 conjugates through SMCC linker

Synthetic Communications

Volumn 34, Issue 13, 2004, Pages 2407-2414

  Chen, Qingqi ^a   Gabathuler, Reinhard ^a  

^a BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

Bioconjugate; Blood brain barrier; Doxorubicin; Melanotransferrin; SMCC linker; Vector mediated approach

Indexed keywords

ACETIC ACID; BENZOTRIAZOL 1 YL N,N,N',N' TETRAMETHYLURONIUM TETRAFLUOROBORATE; BENZOTRIAZOLE DERIVATIVE; BORIC ACID; DOXORUBICIN; MELANOTRANSFERRIN; SUCCINIMIDYL 4 (N MALEIMIDOMETHYL)CYCLOHEXANE 1 CARBOXYLATE; THIOGLYCOLIC ACID; TRANSFERRIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; BLOOD BRAIN BARRIER; BRAIN TUMOR; CANCER CHEMOTHERAPY; CAPILLARY ENDOTHELIUM; CONJUGATE; DRUG DELIVERY SYSTEM; ENDOTHELIUM CELL; IRON TRANSPORT;

EID: 3543061219     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120039494     Document Type: Article

References (9)

1. (a) Arcamone, F. Total synthesis of doxorubicin and related compounds. In Doxrubicin Anticancer Antibiotics; Academic Press: New York, 1981; Chapter 2;
2. (b) Wiernik, P.H. Anthrayclines. Current status of andriamycin and daunorubicin in cancer treatment. In Anthracyclines. Current Status and New Developments; Crooke, S.T., Reich, S.D., Eds.; Academic Press: New York, 1980; Chapter 16, 273-294;
3. (c) Dorr, R.T.; Von Hoff, D.D. Cancer Chemotherapy Handbook, 2nd Ed.; Appleton and Lange: New York, 1994.
4. (a) Yamada, T.; Tsujioka, Y.; Taguchi, J.; Takahashi, M.; Tsuboi, Y.; Moroo, I.; Yang, J.; Jefferies, W.A. Melanotransferrin is produced by senile plaque-associated reactive microglia in alzheimer's disease. Brain Res. 1999, 845 (1), 1-5;
5. (b) Rothenberger, S.; Food, M.R.; Gabthuler, R.; Kennard, M.L.; Yamada, T.; Yasuhara, O.; McGeer, P.L.; Jefferies, W.A. Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium. Brain Res. 1996, 712 (1), 117-121.
6. (a) Chen, Q.; Sowa, D.A.; Cai, J.; Gabathuler, R. Efficient one-pot synthesis of doxorubicin conjugates through its amino group to menalotransferrin p97. Synth. Commun. 2003, 33 (14), 2401-2421;
7. (b) Chen, Q.; Sowa, D.A.; Gabathuler, R. Synthesis of doxorubicin conjugates through hydrazone bonds to melanotransferrin p97. Synth. Commun. 2003, 33 (14), 2377-2390;
8. (c) Chen, Q.; Sowa, D.A.; Gabathuler, R. Synthesis of doxorubicin conjugates through 14-hydroxy group to melanotransferrin p97. Synth. Commun. 2003, 33 (14), 2391-2400.
9. Hermanson, G.T. Bioconjugate Techniques; Academic Press: 1996.