Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation

Bone Marrow Transplantation

Volumn 34, Issue 1, 2004, Pages 85-87

  Copelan, E ^a   Hoshaw Woodard, S ^a   Elder, P ^a   Penza, S ^a   Farag, S ^a   Marcucci, G ^a   Lin, T ^a   Ezzone, S ^a   Scholl, M D ^a   Bechtel, T ^a   Lemeshow, S ^a   Avalos, B ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Autotransplantation; Secondary AML; VP 16

Indexed keywords

BUSULFAN; CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; THIOTEPA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; AUTOTRANSPLANTATION; BREAST CANCER; COHORT ANALYSIS; CONTROLLED STUDY; HODGKIN DISEASE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MYELODYSPLASIA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; STEM CELL MOBILIZATION; SURVIVAL TIME; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGED; BREAST NEOPLASMS; ETOPOSIDE; FEMALE; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; INCIDENCE; LEUKEMIA; LYMPHOMA; MALE; MIDDLE AGED; NEOPLASMS, SECOND PRIMARY; NEURAL TUBE DEFECTS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROBABILITY; TRANSPLANTATION, AUTOLOGOUS;

EID: 3543053426     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704532     Document Type: Article

References (13)

1. Pedersen-Bjergaard J, Pedersen M, Myhre J, Geisler C. High risk of therapy-related leukemia after BEAM chemotherapy and autologous stem cell transplantation for previously treated lymphomas is mainly related to primary chemotherapy and not to the BEAM-transplantation procedure. Leukemia 1997; 11: 1654-1660.
2. Darrington DL, Vose JM, Anderson JR et al. Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J Clin Oncol 1994; 12: 2527-2534.
3. Stone RM, Neuberg D, Soiffer R et al. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1994; 12: 2535-2542.
4. Miller JS, Arthur DC, Litz CE et al. Myelodysplastic syndrome after autologous bone marrow transplantation: an additional late complication of curative cancer therapy. Blood 1994; 83: 3780-3786.
5. Micallef IN, Lillington DM, Apostolidis J et al. Therapy-related myelodysplasia and secondary acute myelogenous leukemia after high-dose therapy with autologous hematopoietic progenitor-cell support for lymphoid malignancies. J Clin Oncol 2000; 18: 947-955.
6. Armitage JO. Myelodysplasia and acute leukemia after autologous bone marrow transplantation (editorial). J Clin Oncol 2000; 18: 945-946.
7. Ketterer N, Salles G, Dumontet C et al. Fludarabine may increase the toxicity of peripheral blood progenitor cell transplantation (abstract). Br J Haematol 1998; 102: 204.
8. Metayer C, Curtis RE, Vose J et al. Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma; a multicenter case-control study. Blood 2003; 101: 2015-2022.
9. Krishnan A, Bhatia S, Slovak ML et al. Predictors of therapy-related leukemia and myelodysplasia, following autologous transplantation for lymphoma: an assessment of risk factors. Blood 2000; 95: 1588-1593.
10. Copelan EA, Ceselski SK, Ezzone SA et al. Mobilization of peripheral blood progenitor cells with high dose etoposide and granulocyte colony-stimulating factor in patients with breast cancer, non-Hodgkin's lyphoma, and Hehmeyer Hodgkin's disease. J Clin Oncol 1997; 15: 759-765.
11. Copelan EA, Penza SL, Pohlman B et al. Autotransplantation following busulfan, etoposide, and cyclophosphamide in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant 2000; 25: 1219-1222.
12. Thirman MJ, Larson RA. Therapy-related myeloid leukemia. In: Nimer SD, Golde DW (eds.). Hematology/Oncology Clinics of North America. Vol. 10. Saunders: Philadelphia, PA, 1996, pp 293-320.
13. Hosing C, Munsell M, Yazji S et al. Risk of therapy-related myelodysplastic syndrome and acute leukemia following high dose chemotherapy and autologous transplantation for non-Hodgkin's lymphomas (abstract). Blood 2000; 96: 401a.