The efficacy and limitations of sirolimus conversion in liver transplant patients who develop renal dysfunction on calcineurin inhibitors

Digestive Diseases and Sciences

Volumn 49, Issue 6, 2004, Pages 1029-1035

  Lam, Patrick ^a   Yoshida, Atsushi ^a   Brown, Kimberly ^a   Abouljoud, Marwan ^a   Bajjoka, Iman ^a   Dagher, Fadi ^a   Moonka, Dilip K ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

calcineurin1; immunosuppression; liver transplantation; nephrotoxicity; sirolimus

Indexed keywords

CALCINEURIN INHIBITOR; CREATININE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GRAFT REJECTION; HUMAN; KIDNEY FAILURE; KIDNEY FUNCTION; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

CALCINEURIN; CREATININE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; SIROLIMUS; TIME FACTORS; TREATMENT OUTCOME;

EID: 3543019105     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DDAS.0000034567.53748.df     Document Type: Article

References (11)

1. Gonwa TA, Mai ML, Melton LB, Hays SR, Goldstein RM, Levy MF, Klintmalm GB: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: Risk of development and treatment. Transplantation 72:1934-1939, 2001
2. Sheiner PA, Magliocca JF, Bodian CA, Kim-Schluger L, Altaca G, Guarrera JV, Emre S, Fishbein TM, Guy SR, Schwartz ME, Miller CM: Long-term medical complications in patients surviving ≥5 years after liver transplant. Transplantion 69:781-789, 2000
3. Cohen AJ, Stegall MD, Rosen CB, Wiesner RH, Leung N, Kremers WK, Zein NN: Chronic renal dysfunction late after liver transplantation. Liver Transpl 8:916-921, 2002
4. Gonwa TA: Hypertension and renal dysfunction in long-term liver transplant recipients. Liver Transpl 7:S22-S26, 2001
5. Myers BD, Ross J, Newton L, Luetscher J, Perlroth M: Cyclosporine- associated chronic nephropathy. N Engl J Med 311:699-705, 1984
6. Watson CJE, Friend PJ, Jamieson NV, Frick TW, Alexander G, Gimson AE, Calne R: Sirolimus: A potent new immunosuppressant for liver transplantation. Transplantion 67:505-509, 1999
7. Chang GJ, Mahanty HD, Quan D, Freise CE, Ascher NL, Roberts JP, Stock PG, Hirose R: Experience with the use of sirolimus in liver transplantation - Use in patients for whom calcineurin inhibitors are contraindicated. Liver Transpl 6:734-740, 2000
8. Herrero JI, Quiroga J, Sangro B, GiralaM, Gomez-Manero N, Pardo F, Alvarez-Cienfuegos J, Prieto J: Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil. Liver Transpl 5:414-420, 1999
9. Barkmann A, Nashan B, Schmidt HMJ, Boker BCHW, Emmanouilidis N, Rosenau J, Bahr MJ, Hoffman MW, Manns MP, Klempnauer J, Schlitt HJ: Improvement of acute and chronic renal dysfunction in liver transplant patients after substitution of calcineurin inhibitors by mycophenolate mofetil. Transplantation 69:1886-1890, 2000
10. Sanchez EQ, Onaca N, Thomas M, Ueno T, Raofi V, Goldstein RM, Levy MF, Chinnakotia S, Dawson S, Randall H, Saracino G, Klintmalm GB: Rapamune conversion in long-term liver transplant patients is effective in recovering renal function. Am J Transpl 3 (Suppl 5):325, 2003 (abstr)
11. Nair S, Eason J, Loss G: Sirolimus monotherapy in nephrotoxicity due to calcineurin inhibitors in liver transplant recipients. Liver Transpl 9:124-129, 2003