Lipoprotein Lp(a): Effects of allelic variation at the LPA locus

Journal of Experimental Zoology

Volumn 282, Issue 1-2, 1998, Pages 54-61

  Rainwater, David L ^a   Kammerer, Candace M ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; PAPIO; PAPIO HAMADRYAS;

EID: 3543011303     PISSN: 0022104X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-010X(199809/10)282:1/2<54::AID-JEZ9>3.0.CO;2-M     Document Type: Article

References (55)

1. Azrolan, N., D. Gavish, and J.L. Breslow (1991) Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (Apo(a)) protein size and the abundance of hepatic Apo(a) mRNA in a cynomolgus monkey model. J. Biol. Chem., 266:13866-13872.
2. Berg, K. (1963) A new serum type system in man-the Lp system. Acta Pathol. Microbiol. Scand., 53:369-382.
3. Boerwinkle, E., H.J. Menzel, H.G. Kraft, and G. Utermann (1989) Genetics of the quantitative Lp(a) lipoprotein trait. III: contribution of Lp(a) glycoprotein phenotypes to normal lipid variation. Hum. Genet., 82:73-78.
4. Boerwinkle, E., C.C. Leffert, J. Lin, C. Lackner, G. Chiesa, and H.H. Hobbs (1992) Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest., 90:52-60.
5. Cohen, J.C., G. Chiesa, and H.H. Hobbs (1993) Sequence polymorphisms in the apolipoprotein (a) gene: evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels. J. Clin. Invest., 91:1630-1636.
6. DeMeester, C.A., X. Bu, R.J. Gray, A.J. Lusis, and J.I. Rotter (1995) Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus. Am. J. Hum. Genet., 56:287-293.
7. Doucet, C., T. Huby, J. Ruiz, M.J. Chapman, and J. Thillet (1995) Non-enzymatic glycation of lipoprotein(a) in vitro and in vivo. Atherosclerosis, 118:135-143.
8. Drayna, D.T., R.A. Hegele, P.E. Hass, M. Emi, L.L. Wu, D.L. Eaton, R.M. Lawn, R.R. Williams, R.L. White, and J.-M. Lalouel (1988) Genetic linkage between lipoprotein(a) phenotype and a DNA polymorphism in the plasminogen gene. Genomics, 3:230-236.
9. Eaton, D.L., G.M. Fless, W.J. Kohr, J.W. McLean, Q.-T. Xu, C.G. Miller, R.M. Lawn, and A.M. Scanu (1987) Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen. Proc. Natl. Acad. Sci. USA, 84:3224-3228.
10. Ernst, A., M. Helmhold, C. Brunner, A. Pethö-Schramm, V.W. Armstrong, and H.-J. Müller (1995) Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a). J. Biol. Chem., 270:6227-6234.
11. Gaubatz, J.W., C. Heideman, A.M. Gotto, Jr., J.D. Morrisett, and G. Dahlen (1983) Human plasma lipoprotein (a): structural properties. J. Biol. Chem., 258:4582-4589.
12. Gaubatz, J.W., K.I. Ghanem, J. Guevara, Jr., M.L. Nava, W. Patsch, and J.D. Morrisett (1990) Polymorphic forms of human apolipoprotein(a): inheritance and relationship of their molecular weights to plasma levels of lipoprotein(a). J. Lipid Res., 31:603-613.
13. Gavish, D., N. Azrolan, and J.L. Breslow (1989) Plasma Lp(a) concentration is inversely correlated with the ratio of kringle IV/kringle V encoding domains in the apo(a) gene. J. Clin. Invest., 84:2021-2027.
14. Gaw, A., E. Boerwinkle, J.C. Cohen, and H.H. Hobbs (1994) Comparative analysis of the apo(a) gene, apo(a) glycoprotein and plasma concentrations of Lp(a) in three ethnic groups: evidence for no common "null" allele at the apo(a) locus. J. Clin. Invest., 93:2526-2534.
15. Grainger, D.J., H.L. Kirschenlohr, J.C. Metcalfe, P.L. Weissberg D.P. Wade, and R.M. Lawn (1993) Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science, 260:1655-1658.
16. Grainger, D.J., P.R. Kemp, A.C. Liu, R.M. Lawn, and J.C. Metcalfe (1994) Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice. Nature, 370:460-462.
17. Hajjar, K.A., and R.L. Nachman (1996) The role of lipoprotein(a) in atherogenesis and thrombosis. Annu. Rev. Med., 47:423-442.
18. Hajjar, K.A., D. Gavish, J.L. Breslow, and R.L. Nachman (1989) Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature, 339:303-305.
19. Hervio, L., M.J. Chapman, J. Thillet, S. Loyau, and E. Anglés-Cano (1993) Does apolipoprotein(a) heterogeneity influence lipoprotein(a) effects on fibrinolysis. Blood, 82:392-397.
20. Hixson, J.E., M.L. Britten, G.S. Manis, and D.L. Rainwater (1989) Apolipoprotein(a) (apo(a)) glycoprotein isoforms resuit from size differences in apo(a) mRNA in baboons. J. Biol. Chem., 264:6013-6016.
21. Ichinose, A., and M. Kuriyama (1995) Detection of polymorphisms in the 5′-flanking region of the gene for apolipoprotein(a). Biochem. Biophys. Res. Commun., 209:372-378.
22. Jauhiainen, M., P. Koskinen, C. Enholm, M.H. Frick, M. Mänttäri, V. Manninen, and J.K. Huttunen (1991) Lipoprotein (a) and coronary heart disease risk: a nested case-control study of the Helsinki Heart Study participants. Atherosclerosis, 89:59-67.
23. Kammerer C.M., D.L. Rainwater, and J.L. VandeBerg (1992) Preliminary evidence that two genes affect Lp(a) levels in baboons. Second International Conference on Lp[a]. Program/Abstract Book, p. 100 (abstract).
24. Klezovitch, O., C. Edelstein, and A.M. Scanu (1996) Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes. J. Clin. Invest., 98:185-191.
25. Kraft, H.G., C. Haibach, A. Lingenhel, C. Brunner, M. Trommsdorff, F. Kronenberg, H.J. Müller, and G. Utermann (1995) Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the apolipoprotein (a) size polymorphism. Hum. Genet., 95:275-282.
26. Kraft, H.G., A. Lingenhel, R.W.C. Pang, R. Delport, M. Trommsdorff, H. Vermaak, E.D. Janus, and G. Utermann (1996) Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur. J. Hum. Genet., 4:74-87.
27. Kronenberg, F., A. Steinmetz, G.M. Kostner, and H. Dieplinger (1996) Lipoprotein(a) in health and disease. Crit. Rev. Clin. Lab. Sci., 33:495-543.
28. Lackner, C., E. Boerwinkle, C.C. Leffert, T. Rahmig, and H.H. Hobbs (1991) Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. J. Clin. Invest., 87:2153-2161.
29. Lackner, C., J.C. Cohen, and H.H. Hobbs (1993) Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum. Mol. Genet., 2:933-940.
30. Leerink, C.B., P.F.C.C.M. Duif, J.A. Gimpel, W. Kortlandt, B.N. Bouma, and H.J.M. Van Rijn (1992) Lysine-binding heterogeneity of Lp(a): consequences for fibrin binding and inhibition of plasminogen activation. Thromb. Haemost., 68:185-188.
31. Leerink, C.B., P.F.C.C.M. Duif, N. Verhoeven, C.M. Hackeng, F.R. Leus, J. Prins, B.N. Bouma, and H.J.M. Van Rijn (1994) Apolipoprotein(a) isoform size influences binding of lipoprotein(a) to plasmin-modified des-AA-fibrinogen. Fibrinolysis, 8:214-220.
32. Mancini, F.P., V. Mooser, R. Guerra, and H.H. Hobbs (1995) Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels. Hum. Mol. Genet., 4:1535-1542.
33. Marcovina, S.M., Z.H. Zhang, V.P. Gaur, and J.J. Albers (1993) Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites. Biochem. Biophys. Res. Commun., 191:1192-1196.
34. McLean, J.W., J.E. Tomlinson, W.-J. Kuang, D.L. Eaton, E.Y. Chen, G.M. Fless, A.M. Scanu, and R.M. Lawn (1987) cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature, 330:132-137.
35. Miles, L.A., G.M. Fless, E.G. Levin, A.M. Scanu, and E.F. Plow (1989) A potential basis for the thrombotic risks associated with lipoprotein(a). Nature, 339:301-303.
36. Mooser, V., F.P. Mancini, S. Bopp, A. Pethö-Schramm, R. Guerra, E. Boerwinkle, H.-J. Müller, and H.H. Hobbs (1995) Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma. Hum. Mol. Genet., 4:173-181.
37. Rainwater, D.L. (1995) Genetic basis for multimodal relationship between apolipoprotein(a) size and lipoprotein(a) concentration in Mexican Americans. Atherosclerosis, 115: 165-171.
38. Rainwater, D.L. (1996) Lp(a) concentrations are related to plasma lipid concentrations. Atherosclerosis, 127:13-18.
39. Rainwater, D.L., G.S. Manis, and J.L. VandeBerg (1989) Hereditary and dietary effects on apolipoprotein(a) isoforms and Lp(a) in baboons. J. Lipid Res., 30:549-558.
40. Rainwater, D.L., J.W. MacCluer, M.P. Stern, J.L. Vande-Berg, and S.M. Haffner (1994) Effects of NIDDM on lipoprotein(a) concentration and apolipoprotein(a) size. Diabetes, 43:942-946.
41. Rainwater, D.L., C.M. Kammerer, J.L. VandeBerg, and J.E. Hixson (1997) Characterization of the genetic elements controlling lipoprotein(a) concentrations in Mexican Americans: evidence for at least three controlling elements linked to LPA, the locus encoding apolipoprotein(a). Atherosclerosis, 128:223-233.
42. Ridker, P.M., C.H. Hennekens, M.J. Stampfer (1993) A prospective study of lipoprotein(a) and the risk of myocardial infaction. JAMA, 270:2195-2199.
43. Scanu, A.M., D. Pfaffinger, J.C. Lee, and J. Hinman (1994) A single point mutation (Trp72→Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a). Biochim. Biophys. Acta Mol. Basis Dis., 1227:41-45.
44. Segrest, J.P., and R.L. Jackson (1972) Molecular weight determination of glycoproteins by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. Methods Enzymol., 28:54-63.
45. Suzuki, K., M. Kuriyama, T. Saito, and A. Ichinose (1997) Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5′-flanking region. J. Clin. Invest., 99:1361-1366.
46. Trommsdorff, M., S. Köchl, A. Lingenhel, F. Kronenberg, R. Delport, H. Vermaak, L. Lemming, I.C. Klausen, O. Faergeman, G. Utermann, and H.-G. Kraft (1995) A penta-nucleotide repeat polymorphism in the 5′ control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentrations in Caucasians. J. Clin. Invest., 96:150-157.
47. Utermann, G., and W. Weber (1983) Protein composition of Lp(a) lipoprotein from human plasma. FEBS Lett., 154:357-361.
48. Utermann, G., H.J. Menzel, H.G. Kraft, H.C. Duba, H.G. Kemmler, and C. Seitz (1987) Lp(a) glycoprotein phenotypes: inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J. Clin. Invest., 80:458-465.
49. VandeBerg, J.L., L. Weitkamp, C.M. Kammerer, P. Weill, M.J. Aivaliotis, and D.L. Rainwater (1991) Linkage of plasminogen (PLG) and apolipoprotein(a) (LPA) in baboons. Genomics, 11:925-930.
50. Weitkamp, L.R., S.A. Guttormsen, and J.S. Schultz (1988) Linkage between the loci for the Lp(a) lipoprotein (LP) and plasminogen (PLG). Hum. Genet., 79:80-82.
51. White, A.L., J.E. Hixson, D.L. Rainwater, and R.E. Lanford (1994a) Molecular basis for "null" lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon. J. Biol. Chem., 269:9060-9066.
52. White, A.L., D.L. Rainwater, J.E. Hixson, L.E. Estlack, and R.E. Lanford (1994b) Intracellular processing of apo(a) in primary baboon hepatocytes. Chem. Phys. Lipids, 67/ 68:123-133.
53. Williams-Blangero, S., and D.L. Rainwater (1991) Variation in Lp(a) levels and apo(a) isoform frequencies in five baboon subspecies. Hum. Biol., 63:65-76.
54. Ziegler, A., L.L. Field, and A.Y. Sakaguchi (1991) Report of the committee on the genetic constitution of chromosome 6, human gene mapping 11 (1991). Cytogenet. Cell Genet., 58:295-336.
55. Zysow, B.R., G.E. Lindahl, D.P. Wade, B.L. Knight, and R.M. Lawn (1995) C/T polymorphism in the 5′ untranslated region of the apolipoprotein(a) gene introduces an upstream ATG and reduces in vitro translation. Arterioscler. Thromb. Vasc. Biol., 15:58-64.