Effects of 1 MAC desflurane on cerebral metabolism, blood flow and carbon dioxide reactivity in humans

British Journal of Anaesthesia

Volumn 81, Issue 2, 1998, Pages 155-160

  Mielck, F ^a   Stephan, H ^a   Buhre, W ^a   Weyland, A ^a   Sonntag, H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Anaesthetics volatile; Blood flow; Brain; Carbon dioxide reactivity; Desflurane; Metabolism

Indexed keywords

CARBON DIOXIDE; DESFLURANE; GLUCOSE; NORADRENALIN; OXYGEN;

ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; GENERAL ANESTHESIA; GLUCOSE METABOLISM; HEMODYNAMICS; HUMAN; HYPERCAPNIA; MALE; MEAN ARTERIAL PRESSURE; METABOLIC RATE; OXYGEN SATURATION; PRIORITY JOURNAL; VASOCONSTRICTION; VENOUS OXYGEN TENSION;

EID: 3543009554     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.2.155     Document Type: Article

References (29)

1. Lutz LJ, Milde JH, Milde LN.The cerebral functional, metabolic, and hemodynamic effects of desflurane in dogs. Aneahesiohgy 1990; 73:125-131.
2. Milde LN, Milde JH. The cerebral and systemic hemodynamic and metabolic effects of desflurane-induced hypotension in dogs. Anesthesiology 1991; 74:513-518.
3. Lutz L, Alilde JH, Milde LN.The response of the canine cerebral circulation to hyperventilation during anesthesia with desflurane. Anesthesiology 1991; 74:504-507.
4. Muzzi DA, Losasso TJ, Dietz NM, Faust RJ, Cucchiara RF, Milde LN. The effect of desflurane and isoflurane on cerebrospinal fluid pressure in humans with supratentorial mass lesions. Anesthesiology 1992; 76: 720-724.
5. Ornstein E, Young WL, Fleischer LH, Ostapkovich N. Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions. Anesthesiology 1993; 79:498-502.
6. Strebel S, Lam AM, Malta B, MaybergTS, Aaslid R, Newell DW. Dynamic and static cerebral autoregulation during isoflurane, desflurane, and propofol anesthesia. Anesthesiology 1995; 83:66-76.
7. Talke P, Caldwell J, Dodson B, Richardson CA. Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology 1996; 85:999-1004.
8. Tauche M, Kochsiek K, Hei BHW, Rau G, Bretschneider HJ. Technik der Organdurchblutungsmessung mit der ArgonMethode. Zeitschift für Kreislaufforschung 1971; 60:871-880.
9. Bretschneider HJ, Gott L, Hilgert G, Probst R, Rau G. Gaschromatographische Trennung und Analyse von Argon als Basis einer neuen Fremdgasmethode zur Durchblutungsmessung von Organen. Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung 1966; 32: 267-273.
10. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 1979; 6:65-70.
11. Cotev S, Shalit N. Effects of diazepam on cerebral blood flow and oxygen uptake after head injury. Anesthesiology 1975; 43: 117-122.
12. Forster A, Juge O, Morel D. Effects of midazolam on cerebral blood flow in human volunteers. Anesthesiology 1982; 56: 453-455.
13. Renou AM, Vernhiet J, Macrez P, Constant P, Billerey J, Khadaroo MY, Caille JM. Cerebral blood flow and metabolism during etomidate anaesthesia in man. British Journal of Anaesthesia 1978; 50:1047-1050.
14. 2O and fentanyl in patients with supratentorial cerebral tumour, A dose-response study. Acta Anaesthesiologica Scandinavica 1985; 29:490-494.
15. Van Hamme MJ, Ghoneim MM, Ambre JJ. Pharmacokinetics of etomidate, a new intravenous anesthetic. Anesthesiology 1978; 49:274-277.
16. De Ruiter G, Popescu DT, De Boer AG, Smeekens JB, Breimer DD. Pharmacokinetics of etomidate in surgical patients. Archives in International Pharmacodynamics 1981; 249:180-188.
17. Weiskopf RB, Cahalan MK, Eger El II,Yasuda N, Rampil IJ, lonescu P, Lockhart SH, Johnson BH, Freire B, Kelly S. Cardiovascular actions of desflurane in normocarbic volunteers. Anesthesia and Analgesia 1991;73:143-156.
18. Olesen J. The effect of intracarotid epinephrine, norepinephrine, and angiotensin on the regional cerebral blood flow in man. Neurology 1972; 22:978-987.
19. King BD, Sokoloff L, Wechsler RL.The effects of 1-epinephrine and 1-nor-epinephrine upon cerebral circulation and metabolism in man. Journal of Clinical Investigations 1951; 31: 273-279.
20. Lassen NA. Normal average value of CBF in young adults is 50 ml/100g/min. Journal of Cerebral Blood Flow and Metabolism 1985; 5:347-349.
21. Madsen PL, Hasselbalch SG, Hagemann LP, Olsen KS, Bülow J, Holm S, Wildschiodtz G, Paulson OB, Lassen NA. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the KetySchmidt technique. Journal of Cerebral Blood Flow and Metabolism 1995; 15:485-191.
22. Madsen PL, Holm S, Herning M, Lassen NA. Average blood flow and oxygen uptake in the human brain during resting wakefulness: a critical appraisal of the Kety-Schmidt technique. Journal of Cerebral Blood Flow and Metabolism 1993; 13: 646-655.
23. Weyland A, Stephan H, Kazmaier S, Weyland W, Schorn B, Grüne F, Sonntag H. Row velocity measurements as an index of cerebral blood flow. Anesthesiology 1994; 81:1401-1410.
24. Smith AL, Wollmann H. Cerebral blood flow and metabolism: effects of anesthetic drugs and techniques. Anesthesiology 1972; 36:378-100.
25. Stephan H, Weyland A, Kazmaier S, Henze T, Menck S, Sonntag H. Acid-base management during hypothermie cardiopulmonary bypass does not affect cerebral metabolism but does affect blood flow and neurological outcome. British Journal of Anaesthesia 1992; 69:51-57.
26. Todd AIM, Drummond JC. A comparison of the cerebrovascular and metabolic effects of halothane and isoflurane in the cut. Anesthesiology 1984; 60:276-282.
27. Weyland A, Grüne F, Stephan H, v. Spiegel T, Schorn B, Sonntag H. Cerebrovascular effects of 0.8% halothane in man. Journal of Cerebral Blood Flow and Metabolism 1995; 15 (Suppl. 1):S521.
28. Matta BF, MaybergTS, Lam AM. Direct cerebrovasodilatory effects of halothane, isoflurane, and desflurane during propofol-induced isoelectric electroencephalogram in humans. Anesthesiology 1995; 83: 980-985.
29. Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. Journal of Clinical Investigations 1948; 27:484-492.