The pathology of ligamentum flavum in degenerative lumbar disease

Spine

Volumn 29, Issue 15, 2004, Pages 1689-1697

  Okuda, Teruaki ^a,b   Baba, Itsushi ^b   Fujimoto, Yoshinori ^a   Tanaka, Nobuhiro ^a   Sumida, Tadayoshi ^b   Manabe, Hideki ^b   Hayashi, Yuzo ^b   Ochi, Mitsuo ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA CITY ASA HOSPITAL   (Japan)

Author keywords

Ligamentum flavum; Lumbar spine; Pathology

Indexed keywords

COLLAGEN FIBER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DECOMPRESSION SURGERY; DEGENERATION; ELASTIC FIBER; ELECTROKYMOGRAPHY; FEMALE; HUMAN; HUMAN TISSUE; LIGAMENTUM FLAVUM; LUMBAR SPINE; MALE; MYELOGRAPHY; PATHOLOGY; PRIORITY JOURNAL; SPONDYLOLISTHESIS; SYMPTOMATOLOGY; VERTEBRAL CANAL STENOSIS;

AGED; CALCINOSIS; FEMALE; HUMANS; LIGAMENTUM FLAVUM; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; SPINAL STENOSIS; SPONDYLOLISTHESIS;

EID: 3542998653     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.BRS.0000132510.25378.8C     Document Type: Article

References (59)

1. Elsberg CA. Experimences in spinal surgery. Surg Gynecol Obstet. 1913;16: 117-132.
2. Beamer YB, Garner JT, Shelden HS. Hypertrophied ligamentum flavum. Arch Surg. 1973;106:289-292.
3. Spurling RG, Mayfield FH, Rogers JB. Hypertrophy of the ligamenta flava as a cause of low back pain. JAMA. 1937;109:928-933.
4. Towne EB, Reichert FL. Compression of the lumbosacral roots of the spinal cord by thickened ligamenta flava. Ann Surg. 1931;94:327-336.
5. Sortland O, Magnaes B, Hauge T. Functional myelography with metrizamide in the diagnosis of lumbar spinal stenosis. Acta Radiol Suppl. 1977; 355:42-54.
6. Teng P, Papatheodorou C. Myelographic findings in spondylosis of the lumbar spine. Br J Radiol. 1963;36:122-128.
7. Avrahami E, Wigler I, Stern D, et al. Computed tomographic (CT) demonstration of the ligamenta flava of the lumbosacral spine associated with protrusion of the intervertebral disc. Spine. 1990;15:21-23.
8. Kirkaldy-Willis WH, Heithoff KB, Tchang S, et al. Lumbar spondylosis and stenosis: correlation of pathologic anatomy with high resolution computed tomography scanning. In: Post JD, ed. Computed Tomography of the Spine. Baltimore: Williams & Wilkins, 1984:546-549.
9. Ulrich CG, Binet EF, Sanecki MG, et al, Quantitative assessment of the spinal canal by computed tomography. Radiology. 1980;134:137-143.
10. Yoshida M, Shima K, Taniguchi Y, et al. Hypertrophied ligamentum flavum in lumbar spinal canal stenosis. Spine. 1992;17:1353-1360.
11. Grenier N, Kressel HY, Schiebler ML, et al. Normal and degenerative posterior spinal structures: MR imaging. Radiology. 1987;165:517-525.
12. Mensor MC, Fender FA. The ligamentum flavum: its relationship to low back pain. Surg Gynecol Obstet. 1941;73:822-827.
13. Nachemson AL, Evans JH. Some mechanical properties of the third human lumbar interlaminar ligament (ligamentum flavum). J Biomech. 1968;1:211-220.
14. Postacchini F, Gumina S, Cinotti G, et al. Ligamenta flava in lumbar disc herniation and spinal stenosis. Spine. 1994;8:917-922.
15. Ramsey R. The Anatomy of the ligamentum flavum. Clin Orthop. 1966;44: 129-140.
16. Schrader P, Grob D, Rahn BA, et al. Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis. Eur Spine J. 1999;8:323-328.
17. Okada K, Oka S, Toghe K, et al. Thoracic myelopathy caused by ossification of the ligamentum flavum: clinicopathologic study and surgical treatment. Spine. 1991;16:280-287.
18. Verbiest H. Further experiences on the pathological influence of a developmental narrowness of the bony lumbar vertebral canal. J Bone Joint Surg Br. 1955;37:576-583.
19. Yamada H, Okya M, Okada T, et al. Intermittent cauda equina compression due to narrow spinal canal. J Neurosurg. 1972;37:83-88.
20. Yong-Hing K, Reilly J, Kirkaldy-Willis W. The ligamentum flavum. Spine. 1976;1:226-234.
21. Baker JK, Hanson GW. Cyst of the ligamentum flavum. Spine. 1994;19: 1092-1094.
22. Bilbao JM, Horsey W, Gonsalves C, et al. Compression of the cauda equina due to a necrobiotic granuloma of the ligamentum flavum. Can J Neurol Sci. 1975;2:135-138.
23. Cruz-Conde R, Berjano P, Buitron Z. Ligamentum flavum hematoma presenting as progressive root compression in the lumbar spine. Spine. 1995;20: 1506-1509.
24. Kao CC, Uihlein A, Bickel WH, et al. Lumbar intraspinal extradural ganglion cyst. J Neurosurg. 1968;29:168-172.
25. Kao CC, Winkler SS, Turner JH. Synovial cyst of spinal facet: case report. J Neurosurg. 1974;41:372-376.
26. Mahallani H, Wallace CJ, Hunter KM, et al. MR imaging of a hemorrhagic and granulomatous cyst of the ligamentum flavum with pathologic correlation. AJNR Am J Neuroradiol. 1999;20:1166-1168.
27. Minamide A, Yoshida M, Tamaki T, et al. Ligamentum flavum hematoma in the lumbar spine. Orthop Sci. 1999;4:376-379.
28. Onfrio BM, Mih AD. Synovial cysts of the spine. Neurosurgery. 1988;22: 642-647.
29. Vernet O, Fankhauser H, Schnyder P, et al. Cyst of the ligamentum flavum: report of six cases. Neurosurgery. 1991;29:277-283.
30. Baba H, Maezawa Y, Furosawa N, et al. The role of calcium deposition in the ligamentum flavum causing a cauda equina syndrome and lumbar radiculopathy. Paraplegia. 1995;33:219-223.
31. Dockerty, MB, Love JG. Thicking and fibrosis (so-called hypertrophy) of the ligamentum flavum: a pathologic study of fifty cases. Proc Staff Meet Mayo Clin. 1940;15:161-166.
32. Yonenobu K, Ebara S, Fujiwara K, et al. Thoracic myelopathy secondary to ossification of the spinal ligament. J Neurosurg. 1987;66:511-518.
33. Nakamura T, Hashimoto N, Maeda Y, et al. Degeneration and ossification of the yellow ligament in unstable spine. J Spinal Disord. 1990;3:288-292.
34. Kikuchi S, Hasue M. Clinical analyses of neurogenic intermittent claudication in lumbar spine disease. Orthop Trans. 1985;9:514.
35. Kawahara E, Oda Y, Katsuda S, et al. Microfilamentous type VI collagen in the hyalinized stroma of hypertrophied ligamentum flavum. Virchows Arch [A]. 1991;419:373-380.
36. Polgar F. Ueber intrartikulare Wirbelvcerkalkung. Fortschr Geb Roentgen. 1920;40:292-298.
37. Berghausen EJ, Balogh K, Landis W, et al. Cervical myelopathy attributable to pseudgout. Clin Orthop. 1987;214:217-221.
38. Iwasaki Y, Akino M, Abe H, et al. Calcification of the ligamentum flavum of the cervical spine: report of four cases. J Neurosurg. 1983;59:531-534.
39. Kawano N, Yoshida S, Ohwada T, et al. Cervical radiculopathy caused by deposition of calcium pyrophosphate dihydrate crystals in the ligamenta flava: case report. J Neurosurg. 1980;52:279-283.
40. Nagashima C, Takahama M, Shibata T, et al. Calcium pyrophosphate dihydrate deposits in the cervical ligamenta flava causing myeloradiculopathy. J Neurosurg. 1984;60:69-80.
41. Okada A, Harata S, Takeda Y, et al. Age-related changes in proteoglycans of human ligamentum flavum. Spine. 1993;18:2261-2266.
42. Carrera GF, Haughton VM, Syvertsen A, et al. Computed tomography of the lumbar facet joints. Radiology. 1980;134:145-158.
43. Dehais J, Senegas J, Bauduceau B, et al. Stenoe du canal rachidien lumbaire au cours d,une chondrocalcinose articulaire diffuse. Rev Rhum Mal Osteoartic. 1977;44:585-588.
44. Drouillard pj, Mrstik LL. Lumbar spinal stenosis associated with hypertrophied ligamentum flavum and calcium pyrophosphate crystal deposition. J Am Osteopath Assoc. 1988;88:1019-1021.
45. Hukins DWL, Kirby MC, Sikorin TA, et al. Comparison of structure, mechanical properties and function of lumbar spinal ligaments. Spine. 1990;15: 787-795.
46. Postacchini F. Lumbar Spinal Stenosis. Berlin: Springer, 1988.
47. Santiago FR, Romero PA, Machado EL, et al. Calcification of lumbar ligamentum flavum and facet joints capsule. Spine. 1997;22:1730-1735.
48. Hijioka A, Suzuki K, Nakamura T, et al. Light and electron microscopy of hydroxyapatite depositions in the ligamentum flavum. Spine. 1994;19: 2626-2631.
49. Anderson HC. Vesicles associated with calcification in the matrix of epiphyseal cartilage. J Cell Biol. 1969;41:59-72.
50. Bonnucci E. The locus of initial calcification in cartilage and bone. Clin Orthop. 1971;78:108-139.
51. Kubota T, Kawano H, Yamashita T, et al. Ultrastructural study of calcification process in the ligamentum flavum of the cervical spine. Spine. 1987;12: 317-323.
52. Kubota M, Baba I, Sumida T. Myelopathy due to ossification of the ligamentum flavum of the cervical spine: a report of two cases. Spine. 1981;6:553-559.
53. Kurihara A, Tanaka Y, Tsumura N, et al. Hyperostotic lumbar spinal stenosis: a review of 12 surgically treated cases with roentgenographic survey of ossification of the yellow ligament at the lumbar spine. Spine. 1988;13: 1308-1316.
54. Williams DM, Gabrielsen, DO, Latack JT. Ossification in the caudal attachments of the ligamentum flavum. Radiology. 1982;145:693-697.
55. Williams DM, Gabrielsen DO, Latack JT, et al. Ossification of the cephalic attachments of the ligamentum flavum. Radiology. 1984;150:423-426.
56. Hayashi K, Ishidou Y, Yonemori K, et al. Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum. Bone. 1997;21:23-30.
57. Cooper RR, Misol S. Tendon and ligament insertion: a light and electron microscopic study. J Bone Joint Surg Am. 1970;52:1-20.
58. Macnab I. The traction spur. J Bone Joint Surg Am. 1971;53:663-670.
59. Sweasey TA, Coester HC, Rawal H, et al. Ligamentum flavum hematoma: report of two cases. J Neurosurg. 1992;76:534-537.