Differential chromosome sensitivity to 5-Azacytidine in Alzheimer's disease

Gerontology

Volumn 44, Issue 5, 1998, Pages 267-271

  Payão, Spencer Luiz Marques ^a,b   De Smith, Marília Arruda Cardoso ^a   Bertolucci, Paulo Henrique Ferreira ^b  

^a 740 Edifício Leitão da Cunha   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 Azacytidine; Alzheimer's disease; Constitutive heterochromatin; Human chromosomes; Methylation

Indexed keywords

AZACITIDINE;

AGED; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 1; CHROMOSOME 16; CHROMOSOME 9; CHROMOSOME CONDENSATION; CHROMOSOME FRAGILE SITE; CLINICAL ARTICLE; CONSTITUTIVE HETEROCHROMATIN; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HUMAN; HUMAN CELL; METHYLATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

EID: 3542991430     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022023     Document Type: Article

References (31)

1. Katzman RN: Medical progress: Alzheimer's disease. N Engl J Med 1986;314:964-973.
2. St George Hyslop PH, Haines JL, Farrer LA, Polinsky R, Broeckhoven CV, Goate A, McLachlan DRC, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growdon J, Fried VA, Myers RH, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montesi M, Mortilla M, Nacmias N, Gusella JF, Hardy JA: Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 1990;347:194-195.
3. St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachmand D, Growdon AB, Foncin JF, Salmon D, Frommelt P, Amaducci L, Sorbi S, Piacentini S, Stewart GD, Hobbs WJ, Conneally PM, Gusella JF: The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987;235:885-890.
4. Pericak-Vance MA, Bebout JL, Gaskall PC, Yamaoka LH, Hung WY, Alberts MJ, Walker AP, Barlett RJ, Haynes CA, Welsh KA, Earl NL, Heyman A, Clark CM, Roses AD: Linkage studies in familial Alzheimer's disease: Evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034-1050.
5. Schellenberg G, Bird T, Wijsman E, Orr H, Anderson L, Nemens E, White J, Bonnycastle L, Weber J, Alonso E, Potter H, Heston L, Martin G: Genetic linkage evidence for a familial Alzheimer's disease locus on chromosomes 14. Science 1992;258:668-671.
6. Nechiporuk A, Fain P, Kort E, Nee LE, Frommelt E, Polinsky RS, Korenberg JR, Pulst SM: Linkage of familial Alzheimer's disease to chromosome 14 in two large early-onset pedigrees. Am J Med Genet 1993;48:63-66.
7. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard AB, Weber JL, Bird TB, Schellenberg G: A familial Alzheimer's disease locus on chromosome 1. Science 1995;269:970-977.
8. Holliday R: A different kind of inheritance. Sci Am 1989;260:40-48.
9. Friedman S: The inhibition of DNA (cytosine-5) methylases by 5-azacytidine: The effect of azacytosine-containing DNA. Mol Pharmacol 1981;19:314-320.
10. Razin A, Cedar H: DNA methylation and gene expression. Microbiol Rev 1991;55:451-458.
11. Murakami T, Li X, Gong J, Bhatia U, Traganos F, Darzynkiewicz Z: Induction of apoptosis by 5-Azacytidine: Drug concentration-dependent differences in cell cycle specificity. Cancer Res 1995;55:3093-3098.
12. Viegas-Péquinot E, Dutrillaux B: Segmentation of human chromosomes induced by 5-ACR (5-azacytidine). Hum Genet 1976;34:247-254.
13. Viegas-Péquinot E, Dutrillaux B: Detection of G-C rich by 5-Azacytidine in mammals. Hum Genet 1981;57:134-137.
14. Schmid M, Grunert D, Haaf T, Engel W: A direct demonstration of somatically paired undercondensation of human chromosomes. Cytogenet Cell Genet 1983;36:554-561.
15. Schmid M, Haaf T, Grunert D: 5-Azacytidineinduced undecondensations in human chromosomes. Hum Genet 1984;67:257-263.
16. Bertolucci PHF, Payão SLM, Smith M de AC: Cytogenetic effect of the 5-Azacytidine (5-AZC) in Alzheimer's disease (abstract 248). Neurobiol Aging 1996;17(suppl 4):62.
17. Morris JC: The clinical dementia rating (CDR): Current version and scoring rules. Neurology 1993;43:2412-2414.
18. Mackhann G, Drachman D, Folstein M, Katzman RN, Price D,.Stadlan EM:Clinical diag-, nosis of Alzheimer's disease. Neurology 1984;34:939-944.
19. Schmid M, Ott G, Haaf T, Scheres JMJC: Evolutionary conservation of fragile sites induced by 5-Azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee. Hum Genet 1985;71:342-350.
20. Moorhead PS, Nowell PS, Mellmann WJ, Battips DM, Hunger-Ford DA: Chromosome preparations of leucocytes cultured from human peripheral blood. Exp Cell Res 1960;20:613-616.
21. Siegel S: Estatística não paramétrera para as ciências do comportamento. São Paulo, McGraw-Hill, 1975.
22. Cooper DN: Eukaryotic DNA methylation. Hum Genet 1983;64:315-333.
23. Doefler W: DNA methylation and gene activity. Annu Rev Biochem 1983;52:93-124.
24. Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:84-93.
25. Jones PA, Taylor SM: Hemimethylated duplex DNAs prepared from 5-Azacytidine-treated cells. Nucleic Acids Res 1981;9:2933-2947.
26. Lu LJW, Randearth K: Effects of 5-Azacytidine on transfer RNA methyltransferase. Cancer Res 1979;39:940-948.
27. Cohen MB, Glazer RI: Cytotoxicity and the inhibition of ribosomal RNA processing in human colon carcinoma cells. Mol Pharmacol 1985;27:308-313.
28. Synder RD, Lachmann PJ: Differential effects of 5-Azacytidine and 5-azadeoxycitidine on cytotoxicity, DNA-strand breaking and repair of X-ray-induced DNA damage in HeLa cells. Mutat Res 1989;226:185-190.
29. Li LH, Olin Ej, Fraser TJ, Bhuyan BK: Phase specificity of 5-azacytidine against mammalian cells in tissue culture. Cancer Res 1970;30:2770-2775.
30. Verma RS: Heterochromatin: Molecular and Structural Aspects, ed 1. London, Cambridge University Press, 1988, pp 50-60.
31. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD: Molecular Biology of the Cell, ed 3. New York, Garland, 1994, pp 391-394.