An observational study of the effectiveness and safety of intramuscular olanzapine in the treatment of acute agitation in patients with bipolar mania or schizophrenia/schizoaffective disorder

Human Psychopharmacology

Volumn 22, Issue 7, 2007, Pages 455-462

  Centorrino, Franca ^a   Meyers, Adam L ^b   Ahl, Jonna ^b   Cincotta, Stephanie L ^a   Zun, Leslie ^c   Gulliver, Angela H ^b   Kinon, Bruce J ^b   Houston, John P ^b  

^a MCLEAN HOSPITAL   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c MOUNT SINAI HOSPITAL   (United States)

Author keywords

Acute agitation; Bipolar mania; IM olanzapine; Schizoaffective disorder; Schizophrenia

Indexed keywords

ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; BENZODIAZEPINE DERIVATIVE; CHLORPROMAZINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONAZEPAM; CLOZAPINE; FLUPHENAZINE; FLURAZEPAM; HALOPERIDOL; LORAZEPAM; MOOD STABILIZER; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; QUETIAPINE; RISPERIDONE; ZOLPIDEM;

ADULT; AGITATION; ANALYSIS OF VARIANCE; ARTHRALGIA; ARTICLE; BIPOLAR MANIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG RESPONSE; DRUG SAFETY; FEMALE; HOSPITAL PATIENT; HUMAN; INSOMNIA; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; OPEN STUDY; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PULSE RATE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEDATION; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; WEIGHT CHANGE;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BIPOLAR DISORDER; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMOTOR AGITATION; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 35349017841     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.870     Document Type: Article

References (12)

1. Allen MH, Currier GW, Hughes DH, Reyes-Harde M, Docherty JP. Expert Concensus guideline series. Treatment of behavioral emergencies. 2001. Postgrad Med May (Spec No): 1-88.
2. Battaglia J, Lindborg SR, Alaka K, Meehan K, Wright P. 2003. Calming versus sedative effects of intramuscular olanzapine in agitated patients. Am. J. Emerg. Med. 21: 192-198.
3. Breier A, Meehan K, Birkett M, et al. 2002. A double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia/ schizoaffective disorder. Arch. Gen. Psychiatr. 59: 441-448.
4. Fleiss JL. 1971. Measuring nominal scale agreement among many raters. Psychol. Bull. 76(5): 378-381.
5. Guy W (ed.). 1976. Clinical Global Impressions, ECDEU Assessment Manual for Psychopharmacology, revised. National Institute of Mental Health: Rockville, MD.
6. Kay SR, Fiszbein A, Opler LA. 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13(2): 261-276.
7. Meehan K, Zhang F, David S, et al. 2001. A double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania. J. Clin. Psychopharmacol. 21(4): 389-397.
8. Milton GV, Jann MW. 1995. Emergency treatment of psychotic symptoms. Pharmacokinetic considerations for antipsychotic drugs. Clin. Pharmacokinet. 28(6): 494-504.
9. Preval H, Klotz SG, Southard R, et al. 2005. Rapid-acting IM ziprasidone in a psychiatric emergency service: a naturalistic study. Gen Hosp Psychiatry 27(2): 140-144.
10. San L, Arranz B, Querejeta I, Barrio S, De la Gándara J, Pérez V. 2006. A naturalistic multicenter study of intramuscular olanzapine in the treatment of acutely agitated manic or schizophrenic patients. Eur. Psychiatr. 21(8): 539-543.
11. Swift RH, Harrigan EP, Cappelleri JC, et al. 2002. Validation of the behavioral activity rating scale (BARS): a novel measure of activity in agitated patients. J Psychiatr Res 36(2): 87-95.
12. Wright P, Birkett M, David SR, et al. 2001. Double-blind, placebo-controlled comparison of intramuscular olanzapine and intramuscular haloperidol in the treatment of acute agitation in schizophrenia/schizoaffective disorder. Am. J. Psychiatr. 158(7): 1149-1151.