Phenylephrine-induced microvascular occlusion syndrome in a patient with a heterozygous factor V Leiden mutation

Archives of Dermatology

Volumn 143, Issue 10, 2007, Pages 1314-1317

  Kalajian, Andrew H ^a   Turpen, Klark B ^a   Donovan, Kristin O ^a   Malone, Janine C ^a   Callen, Jeffrey P ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5 LEIDEN; DALFOPRISTIN PLUS QUINUPRISTIN; FUROSEMIDE; HEPARIN; HYDROCORTISONE SODIUM SUCCINATE; HYDROXYZINE; LEPIRUDEN; LEVOFLOXACIN; METOPROLOL TARTRATE; MIDAZOLAM; NORADRENALIN BITARTRATE; PHENYLEPHRINE; PROPOFOL; UNCLASSIFIED DRUG;

ARTICLE; BLISTER; BLOOD VESSEL OCCLUSION; CASE REPORT; DERMATOLOGY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DRUG DOSE TITRATION; DRUG WITHDRAWAL; GENE MUTATION; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; HYPERTENSION; INTENSIVE CARE; LUNG EMBOLISM; MALE; NEUROSURGERY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PURPURA; SKIN BIOPSY; SKIN DISCOLORATION; THROMBOCYTE COUNT; VASOCONSTRICTION; VASOMOTOR DISORDER;

CONSTRICTION, PATHOLOGIC; DRUG ADMINISTRATION SCHEDULE; FACTOR V; HETEROZYGOTE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; MUTATION; PHENYLEPHRINE; REMISSION INDUCTION; SKIN; VASCULAR DISEASES; VASOCONSTRICTOR AGENTS;

EID: 35349017341     PISSN: 0003987X     EISSN: 0003987X     Source Type: Journal    
DOI: 10.1001/archderm.143.10.1314     Document Type: Article

References (19)

1. Robson KJ, Piette WW. The presentation and differential diagnosis of cutaneous vascular occlusion syndromes. Adv Dermatol. 1999;15:153-182.
2. Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet. 1993;342(8886-8887):1503-1506.
3. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood. 1995;85(6):1504-1508.
4. Price DT, Ridker PM. Factor V leiden mutation and the risks for thromboembolic disease: a clinical perspective. Ann Intern Med. 1997;127(10):895-903.
5. Lensen RPM, Bertina RM, de Ronde H, Vandenbroucke JP, Rosendaal FR. Venous thrombotic risk in family members of unselected individuals with factor V Leiden. Thromb Haemost. 2000;83(6):817-821.
6. Hutchinson J. Severe symmetrical gangrene of the extremities. BMJ. 1891;2:8-9.
7. Patel GK, Morris E, Rashid MR, Anstey AV. Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation. Br J Dermatol. 2000;143(6):1302-1305.
8. Molos MA, Hall JC. Symmetrical peripheral gangrene and disseminated intravascular coagulation. Arch Dermatol. 1985;121(8):1057-1061.
9. Johansen K, Murphy T, Pavlin E, Ledbetter D. Digital ischemia complicating pneumococcal sepsis: reversal with sympathetic blockade. Crit Care Med. 1991;19(1):114-116.
10. Davis MP, Byrd J, Lior T, Rooke TW. Symmetrical peripheral gangrene due to disseminated intravascular coagulation. Arch Dermatol. 2001;137(2):139-140.
11. Park JY, Kanzler M, Swetter SM. Dopamine-associated symmetric peripheral gangrene. Arch Dermatol. 1997;133(2):247-249.
12. Hayes MA, Yau EHS, Hinds CJ, Watson JD. Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med. 1992;18(7):433-436.
13. Stover MC, Perrone J. Images in clinical medicine: vascular occlusion after intraarterial cocaine injection. N Engl J Med. 2006;355(19):2021.
14. Dünser MW, Mayr AJ, Tür A, et al. Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine-resistant vasodilator shock: incidence and risk factors. Crit Care Med. 2003;31(5):1394-1398.
15. Jackson RT, Luplow RE. Adult purpura fulminans and digital necrosis associated with sepsis and the factor V Leiden mutation. JAMA. 1998;280(21):1829-1830.
16. Gibson GE, Su WP, Pittelkow MR. Antiphospholipid syndrome and the skin. J Am Acad Dermatol. 1997;36(6, pt 1):970-982.
17. Wisloff F, Jacobsen EM, Liestol S. Laboratory diagnosis of the antiphospholipid syndrome. Thromb Res. 2003;108(5-6):263-271.
18. McAllister SF, Cleary JD. Blue digits: cyanosis resulting from norepinephrine treatment. Ann Pharmacother. 2005;39(2):383-384.
19. Korenberg RJ, Landau-Price D, Penneys NS. Vasopressin-induced bullous disease and cutaneous necrosis. J Am Acad Dermatol. 1986;15(2, pt 2):393-398.